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thymidine_kinase
Euk-VirBovine_gammaherpesvirus_6
thymidine_kinase__YP_009042000__Bovine_gammaherpesvirus_6__1504288
Identity
- Accession:
- YP_009042000 ↗
- Protein ID:
- thymidine_kinase
- Kingdom:
- euk
Quality
65.3
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Macavirus›
Bovine_gammaherpesvirus_6
TaxID: 1504288
Cluster
View cluster (22 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 234-251_403-505
Domain cluster:
rep: thymidine_kinase__YP_004207857__Cricetid_gammaherpesvirus_2__1605972__D258-282_414-556
CATH (10)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1e2jA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.69 | 64.0 | 4.64e-01 | 99.2% | 82.7% |
| 1osnC00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.66 | 62.0 | 4.45e-01 | 99.2% | 84.7% |
| 3h20A04 | 1.10.1240.50 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › | 0.58 | 31.0 | 3.58e-01 | 71.9% | 69.7% |
| 4gvpA01 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.56 | 37.0 | 3.13e-01 | 71.1% | 39.8% |
| 2vmaA00 | 1.20.81.30 | Mainly Alpha › Up-down Bundle › Receptor-associated Protein › Type II secretion system (T2SS), domain F | 0.54 | 37.0 | 3.76e-01 | 70.2% | 85.2% |
| 1yozA00 | 1.10.3200.10 | Mainly Alpha › Orthogonal Bundle › Hypothetical protein af0941 › AF0941-like | 0.53 | 28.0 | 2.93e-01 | 90.1% | 52.2% |
| 3cf6E05 | 1.10.840.10 | Mainly Alpha › Orthogonal Bundle › Son of Sevenless (SoS) protein; Chain S, domain 2 › Ras guanine-nucleotide exchange factors catalytic domain | 0.53 | 38.0 | 3.13e-01 | 76.9% | 83.8% |
| 2gs4A00 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.53 | 33.0 | 3.02e-01 | 71.1% | 48.1% |
| 7yu4A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.52 | 44.0 | 3.50e-01 | 93.4% | 81.3% |
| 5xdcB01 | 1.10.540.10 | Mainly Alpha › Orthogonal Bundle › Butyryl-Coa Dehydrogenase, subunit A; domain 1 › Acyl-CoA dehydrogenase/oxidase, N-terminal domain | 0.50 | 34.0 | 3.56e-01 | 71.9% | 75.7% |
ECOD (8)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4139293 | 101.1.2.546 ↗ | alpha arrays › HTH › HTH › winged helix domain › Methyltransf_2 | 0.67 | 51.0 | 3.51e-01 | 81.0% | 24.6% |
| 3243294 | 604.12.1.1 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › MIT | 0.65 | 26.0 | 3.32e-01 | 86.0% | 60.0% |
| 3235784 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.57 | 42.0 | 3.43e-01 | 76.9% | 85.3% |
| 5076868 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.51 | 37.0 | 3.25e-01 | 76.9% | 97.5% |
| 4298403 | 5050.1.1.110 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › UNC-93, MFS_1 | 0.51 | 37.0 | 3.19e-01 | 76.9% | 86.7% |
| 5024587 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.51 | 37.0 | 3.29e-01 | 76.0% | 87.2% |
| 5010685 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.51 | 36.0 | 3.38e-01 | 72.7% | 100.0% |
| 5021244 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.50 | 37.0 | 3.28e-01 | 76.9% | 91.4% |
D2
medium
residues 252-276_332-352_386-402_506-562
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF08465.16 best | Herpes_TK_C | 59.4 | 3.20e-16 | 27.5% | 100.0% |
CATH (3)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5d4wA04 | 1.10.8.60 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.53 | 32.0 | 3.54e-01 | 90.8% | 75.5% |
| 4ciuA04 | 1.10.8.60 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › | 0.52 | 32.0 | 3.53e-01 | 85.0% | 76.3% |
| 3khtA00 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.50 | 38.0 | 3.72e-01 | 80.8% | 93.2% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3705501 | 2007.1.3.28 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like › Glyco_transf_61 | 0.54 | 41.0 | 3.41e-01 | 81.7% | 75.5% |
| 3594638 | 7512.1.1.0 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase | 0.52 | 39.0 | 3.24e-01 | 80.0% | 84.0% |
D3
medium
residues 277-331_353-385
Domain cluster:
rep: ORF21__YP_010084385__Retroperitoneal_fibromatosis-associated_herpesvirus__111469__D274-329_354-381
CATH (14)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1e2jA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.89 | 84.0 | 5.59e-01 | 100.0% | 36.3% |
| 2odmA00 | 1.10.287.750 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like | 0.75 | 53.0 | 5.56e-01 | 72.7% | 98.7% |
| 1p5zB00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.69 | 63.0 | 4.60e-01 | 100.0% | 45.4% |
| 1zm7B00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.68 | 63.0 | 4.75e-01 | 100.0% | 47.0% |
| 1p72A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.67 | 58.0 | 4.03e-01 | 100.0% | 33.1% |
| 2fu2A00 | 1.20.1440.50 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Ta0600-like | 0.65 | 43.0 | 4.59e-01 | 83.0% | 76.9% |
| 2gscC00 | 1.20.1440.60 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 23S rRNA-intervening sequence | 0.60 | 46.0 | 4.31e-01 | 81.8% | 82.7% |
| 2kmfA01 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.60 | 45.0 | 4.33e-01 | 79.5% | 75.5% |
| 5x56B00 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.57 | 43.0 | 4.13e-01 | 81.8% | 71.4% |
| 1nktA01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 46.0 | 3.23e-01 | 89.8% | 98.6% |
| 3pvuA02 | 1.10.167.10 | Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 | 0.55 | 38.0 | 4.00e-01 | 78.4% | 80.0% |
| 1ug3A02 | 1.25.40.180 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.55 | 44.0 | 3.95e-01 | 88.6% | 82.0% |
| 2k3pA01 | 1.10.10.1350 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Spidroin domain, C-terminal domain | 0.52 | 43.0 | 3.96e-01 | 94.3% | 88.8% |
| 1tfrA01 | 3.40.50.1010 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease | 0.52 | 41.0 | 3.20e-01 | 88.6% | 52.4% |
ECOD (11)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3753842 | 2004.1.1.70 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › dNK | 0.70 | 65.0 | 4.71e-01 | 100.0% | 41.3% |
| 3229584 | 226.1.1.1 ↗ | a+b two layers › POZ domain › POZ domain › POZ domain › BTB | 0.69 | 47.0 | 3.92e-01 | 88.6% | 39.4% |
| 3574221 | 186.2.1.1 ↗ | alpha arrays › lambda integrase-N-like › VEFS domain › VEFS domain › VEFS-Box | 0.68 | 49.0 | 4.27e-01 | 95.5% | 50.8% |
| 3511990 | 509.1.1.1 ↗ | alpha bundles › PAH2 domain › PAH2 domain › PAH2 domain › PAH | 0.64 | 40.0 | 4.73e-01 | 86.4% | 100.0% |
| 3236445 | 109.4.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat | 0.60 | 46.0 | 3.76e-01 | 94.3% | 43.5% |
| 4029849 | 109.4.1.31 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › MA3 | 0.58 | 50.0 | 4.37e-01 | 95.5% | 96.3% |
| 4228333 | 206.1.1.0 ↗ | a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase | 0.56 | 47.0 | 2.95e-01 | 95.5% | 36.0% |
| 5057996 | 3457.1.1.1 ↗ | alpha bundles › GxGD membrane protease › GxGD membrane protease › GxGD membrane protease › Peptidase_A24 | 0.54 | 42.0 | 3.53e-01 | 85.2% | 53.8% |
| 3722492 | 109.3.1.2 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat › Ank,Ank_2 | 0.53 | 46.0 | 2.78e-01 | 97.7% | 26.4% |
| 4999940 | 3457.1.1.3 ↗ | alpha bundles › GxGD membrane protease › GxGD membrane protease › GxGD membrane protease › Arc_PepC_II | 0.51 | 41.0 | 2.98e-01 | 88.6% | 35.4% |
| 3991092 | 148.1.3.0 ↗ | alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain | 0.51 | 31.0 | 2.97e-01 | 90.9% | 50.5% |