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thymidine_kinase

Euk-Vir

Equid_gammaherpesvirus_5

thymidine_kinase__YP_009118411__Equid_gammaherpesvirus_5__10371

Identity

Accession:
YP_009118411 ↗
Protein ID:
thymidine_kinase
Kingdom:
euk

Quality

63.9 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 300-425_605-623
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 62.3 6.60e-17 81.4% 43.6%
CATH (22)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1p72A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.88 85.0 6.25e-01 100.0% 98.5%
1e2jA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.87 84.0 6.30e-01 99.3% 98.7%
1osnC00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.86 82.0 6.13e-01 99.3% 100.0%
2yogA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.63 53.0 4.76e-01 89.7% 95.9%
1lw7A02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.60 44.0 4.34e-01 85.5% 69.6%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.59 40.0 4.38e-01 80.0% 86.2%
2lpeA01 6.10.140.1120 Special › Helix non-globular › Helix Hairpins › 0.59 28.0 3.61e-01 73.1% 79.5%
6ln3A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.58 46.0 4.13e-01 84.1% 82.2%
3kb2A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.57 37.0 3.53e-01 86.9% 55.6%
1bifA01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.57 46.0 4.12e-01 86.9% 95.1%
2vl6A01 3.30.1640.10 Alpha Beta › 2-Layer Sandwich › mini-chromosome maintenance (MCM) complex, chain A, domain 1 › mini-chromosome maintenance (MCM) complex, chain A, domain 1 0.55 26.0 3.03e-01 79.3% 62.6%
1hqoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.54 37.0 3.94e-01 73.8% 77.9%
2plrA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.54 45.0 3.96e-01 89.0% 100.0%
1uf9A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.54 44.0 4.07e-01 89.0% 99.5%
7z67A01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.53 43.0 3.74e-01 85.5% 75.7%
3v9pB00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.53 43.0 3.90e-01 88.3% 63.9%
4iw9A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 36.0 4.02e-01 71.0% 96.5%
1m8pA03 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.52 43.0 3.99e-01 89.0% 97.8%
4l8eA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.52 33.0 3.67e-01 72.4% 81.8%
1a7jA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.52 43.0 3.51e-01 90.3% 99.6%
4a15A04 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.50 41.0 3.79e-01 88.3% 98.4%
3wd6A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.50 30.0 3.29e-01 71.7% 71.2%
ECOD (30)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
9545 2004.1.1.52 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.90 87.0 6.38e-01 100.0% 98.5%
9546 2004.1.1.52 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.86 83.0 6.16e-01 100.0% 100.0%
2167612 2004.1.1.79 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin 0.66 47.0 4.85e-01 83.4% 75.7%
4928969 2004.1.1.79 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin 0.64 53.0 4.75e-01 88.3% 63.3%
5037208 2004.1.1.79 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin 0.63 51.0 4.40e-01 85.5% 61.4%
3253981 604.5.1.0 alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) 0.62 47.0 4.01e-01 80.0% 51.2%
4942854 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.62 49.0 4.38e-01 89.0% 60.5%
3950209 2004.1.1.79 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin 0.61 50.0 4.36e-01 84.8% 63.8%
4213018 2004.1.1.79 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin 0.61 51.0 4.50e-01 88.3% 99.0%
3708933 2004.1.1.65 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › 6PF2K 0.61 51.0 4.19e-01 87.6% 81.6%
3738725 2004.1.1.65 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › 6PF2K 0.61 51.0 4.27e-01 89.0% 86.3%
4932083 4163.1.1.1 alpha bundles › GINS helical bundle-like › GINS helical bundle-like › PSF1 N-terminal domain-like › Sld5 0.61 32.0 3.47e-01 75.2% 59.2%
3754962 2004.1.1.65 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › 6PF2K 0.60 50.0 4.12e-01 88.3% 81.5%
3960587 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.60 49.0 4.30e-01 85.5% 64.3%
2390393 2004.1.1.79 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin 0.60 48.0 4.25e-01 84.8% 63.5%
3431291 2004.1.1.41 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ADK 0.59 39.0 4.35e-01 83.4% 86.4%
5009778 2004.1.1.79 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin 0.57 47.0 4.15e-01 89.0% 100.0%
3251152 2004.1.1.192 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_18 0.56 47.0 4.06e-01 89.0% 62.3%
3976441 633.10.1.0 alpha bundles › Bromodomain-like › IVS-encoded protein-like › IVS-encoded protein-like 0.56 39.0 4.12e-01 80.0% 81.6%
3597121 2004.1.1.0 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases 0.55 44.0 3.51e-01 84.8% 93.9%
3891699 2004.1.1.41 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ADK 0.55 46.0 4.23e-01 89.0% 96.8%
3850353 150.1.1.31 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Tweety 0.55 42.0 4.10e-01 79.3% 90.3%
3882598 2004.1.1.635 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › KTI12, AAA_33 0.54 45.0 3.93e-01 89.7% 98.6%
4076300 2004.1.1.44 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › PRK 0.54 45.0 3.60e-01 89.7% 98.6%
3215510 601.16.1.0 alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase 0.53 38.0 3.90e-01 73.1% 87.9%
3610730 603.1.1.0 alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.52 38.0 4.24e-01 80.7% 96.5%
4627252 7589.1.1.2 a/b three-layered sandwiches › YgbK-like › YgbK-like › YgbK-like › NBD_C 0.52 35.0 3.38e-01 87.6% 58.2%
3494824 2004.1.1.112 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › P-mevalo_kinase 0.52 42.0 3.82e-01 86.9% 100.0%
5038481 2004.1.1.29 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › DEAD 0.51 39.0 3.25e-01 82.1% 78.9%
3740404 2004.1.1.1 a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA 0.51 40.0 3.90e-01 84.1% 81.2%
D2 medium residues 484-581
PDB
CATH (13)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3ulqB00 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.55 34.0 3.95e-01 75.5% 100.0%
2yxlA01 1.10.940.10 Mainly Alpha › Orthogonal Bundle › N-utilizing Substance Protein B Homolog; Chain A › NusB-like 0.54 43.0 3.74e-01 84.7% 86.8%
5f64A02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.54 36.0 4.00e-01 78.6% 90.7%
4h79A00 1.10.520.40 Mainly Alpha › Orthogonal Bundle › Peroxidase; domain 1 › CRISPR-associated protein Cse2 0.53 44.0 3.71e-01 91.8% 100.0%
2o38A01 1.10.260.40 Mainly Alpha › Orthogonal Bundle › 434 Repressor (Amino-terminal Domain) › lambda repressor-like DNA-binding domains 0.53 27.0 3.19e-01 85.7% 70.8%
2vvwA00 1.10.437.20 Mainly Alpha › Orthogonal Bundle › Apoptosis Regulator Bcl-x › dsDNA poxvirus 0.53 40.0 3.52e-01 81.6% 81.3%
8ex5A02 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.53 45.0 3.59e-01 100.0% 97.3%
4gc0A02 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.52 43.0 3.48e-01 100.0% 91.2%
2p6rA03 1.10.3380.30 Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › 0.51 41.0 3.30e-01 90.8% 65.6%
3k3oA02 1.20.58.1360 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.51 33.0 3.53e-01 84.7% 76.2%
2w3cA01 1.25.10.10 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › Leucine-rich Repeat Variant 0.51 35.0 2.57e-01 70.4% 26.8%
2ozzA01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.51 38.0 3.47e-01 81.6% 100.0%
1t0fA02 1.10.10.10 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain 0.51 39.0 3.96e-01 92.9% 84.8%
ECOD (26)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3169517 109.46.1.1 alpha superhelices › Repetitive alpha hairpins › Helical domain in TOPLESS related protein 2 (TPR2) › Helical domain in TOPLESS related protein 2 (TPR2) › CTLH 0.57 44.0 3.90e-01 85.7% 55.3%
5005404 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.57 47.0 3.85e-01 92.9% 91.8%
4937507 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.56 46.0 3.64e-01 88.8% 91.9%
3692841 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.55 46.0 3.49e-01 95.9% 69.8%
3701020 604.12.1.0 alpha bundles › Spectrin repeat-like › MIT domain › MIT domain 0.54 30.0 3.32e-01 94.9% 66.3%
3251737 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.54 44.0 3.47e-01 89.8% 89.8%
4955566 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.54 45.0 3.73e-01 96.9% 96.4%
5070991 101.1.6.0 alpha arrays › HTH › HTH › TrpR 0.54 31.0 3.47e-01 70.4% 75.7%
3730728 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.54 44.0 3.65e-01 92.9% 96.3%
4948140 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.53 43.0 3.54e-01 89.8% 90.5%
3385722 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.53 44.0 3.67e-01 94.9% 92.6%
4010186 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.53 43.0 3.58e-01 93.9% 91.3%
3506731 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.52 41.0 3.35e-01 85.7% 88.7%
3733180 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.52 43.0 3.51e-01 96.9% 82.8%
3579241 192.29.1.50 alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › PTPLA 0.52 41.0 3.94e-01 85.7% 93.9%
3539317 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.52 42.0 3.27e-01 90.8% 74.0%
3934022 616.1.1.0 alpha arrays › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain › S15/NS1 RNA-binding domain 0.52 37.0 3.74e-01 90.8% 73.0%
3838664 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.52 42.0 3.55e-01 93.9% 95.7%
4192694 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 42.0 3.32e-01 93.9% 83.5%
5066059 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 41.0 3.44e-01 89.8% 93.0%
4024693 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 42.0 3.52e-01 96.9% 94.9%
5057818 5059.1.1.0 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.51 39.0 3.73e-01 87.8% 69.2%
3290263 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.51 42.0 3.46e-01 95.9% 95.0%
3976020 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.50 41.0 3.43e-01 93.9% 90.3%
4991039 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.50 41.0 3.28e-01 88.8% 85.5%
3673448 192.4.1.37 alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) › Cas1_AcylT 0.50 38.0 3.57e-01 80.6% 87.5%