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thymidine_kinase

Euk-Vir

Human_alphaherpesvirus_2

thymidine_kinase__YP_009137174__Human_alphaherpesvirus_2__10310

Identity

Accession:
YP_009137174 ↗
Protein ID:
thymidine_kinase
Kingdom:
euk

Quality

80.8 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Human_alphaherpesvirus_2

TaxID: 10310

Cluster

View cluster (35 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 55-73_167-269_283-355
PDB
Domain cluster: rep: thymidina_kinase__YP_009664657__Bubaline_alphaherpesvirus_1__202910__D121-329
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 216.3 7.50e-64 78.5% 59.6%
D2 medium residues 74-166_356-376
PDB
Domain cluster: rep: ORF38_gene_product__YP_006273018__Equid_alphaherpesvirus_8__39637__D59-120_334-352
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00693.25 best Herpes_TK 135.0 4.30e-39 87.7% 34.6%
CATH (22)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1e2jA00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.94 89.0 6.17e-01 97.4% 92.2%
1p72A00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.78 73.0 5.14e-01 99.1% 91.6%
1osnC00 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.76 71.0 5.03e-01 100.0% 90.7%
1yxrA01 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.68 34.0 4.13e-01 70.2% 73.0%
1hqoA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.67 44.0 4.21e-01 88.6% 58.0%
2e9xB02 1.20.58.1020 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.66 38.0 3.90e-01 86.0% 58.7%
4l8eA02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.65 38.0 3.91e-01 87.7% 59.1%
3mq1A01 1.20.58.970 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 38.0 4.11e-01 84.2% 75.0%
3uumA00 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.61 36.0 3.60e-01 80.7% 54.9%
4kb2A01 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.60 39.0 4.05e-01 88.6% 68.8%
7zmgL01 1.10.287.3510 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.60 33.0 3.80e-01 85.1% 73.8%
1wcrA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.58 39.0 4.05e-01 75.4% 73.8%
4d8mA01 1.20.190.10 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain 0.58 42.0 3.48e-01 77.2% 43.5%
4adzA00 1.20.58.1000 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer 0.57 39.0 4.30e-01 71.9% 88.9%
2g2dA00 1.20.1200.10 Mainly Alpha › Up-down Bundle › Hypothetical Protein Ta1238; Chain: A; › Cobalamin adenosyltransferase-like 0.57 35.0 3.16e-01 90.4% 43.1%
2jaeA03 1.20.1440.240 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.56 37.0 3.92e-01 88.6% 75.2%
1yozA00 1.10.3200.10 Mainly Alpha › Orthogonal Bundle › Hypothetical protein af0941 › AF0941-like 0.56 33.0 3.33e-01 88.6% 58.4%
5fmnA00 1.20.58.1000 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer 0.55 38.0 4.30e-01 71.9% 94.2%
4oydB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.53 40.0 3.99e-01 79.8% 85.5%
1qsdA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.52 37.0 3.95e-01 88.6% 84.3%
3v0aB02 1.20.1120.10 Mainly Alpha › Up-down Bundle › "Clostridium botulinum neurotoxin B, ""coiled-coil"" domain" › "Clostridium botulinum neurotoxin b, ""coiled-coil"" domain" 0.52 39.0 2.80e-01 78.9% 54.1%
5mlc900 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.51 39.0 4.00e-01 78.9% 84.1%
ECOD (29)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
1322887 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.91 88.0 6.12e-01 99.1% 92.2%
9545 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.85 79.0 5.51e-01 99.1% 91.9%
9546 2004.1.1.52 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK 0.80 72.0 5.03e-01 95.6% 90.8%
3970512 5086.1.1.189 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_CzcB 0.73 41.0 4.94e-01 86.8% 84.0%
4661834 109.4.1.179 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nro1 0.69 42.0 3.49e-01 81.6% 34.5%
3650518 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.69 38.0 2.88e-01 88.6% 23.6%
3741603 603.1.1.5 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Syntaxin-6_N 0.66 40.0 3.92e-01 71.9% 55.2%
4311810 605.1.1.1 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.66 36.0 4.29e-01 82.5% 80.0%
3988454 605.1.1.1 ↗ alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA 0.65 38.0 4.62e-01 78.1% 92.9%
4013155 376.1.1.100 ↗ few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › PF26148 0.64 35.0 3.51e-01 88.6% 51.3%
4882418 208.1.1.55 ↗ beta duplicates or obligate multimers › Single-stranded left-handed beta-helix › Trimeric LpxA-like enzymes › Trimeric LpxA-like enzymes › Oxidored_q2 0.64 32.0 3.64e-01 86.0% 61.4%
4420321 7015.1.1.0 ↗ alpha bundles › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain › Palmitoyltransferase DHHC transmembrane domain 0.60 38.0 3.77e-01 73.7% 59.2%
2791537 3843.1.1.1 ↗ alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › Oxidored_q2 0.58 38.0 3.94e-01 93.9% 71.2%
3635931 109.4.1.0 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.57 40.0 2.66e-01 71.1% 33.3%
3946572 5001.1.1.15 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TMR-DISM_7TM 0.57 38.0 3.04e-01 74.6% 34.2%
5043291 603.1.1.0 ↗ alpha bundles › STAT-like › t-snare proteins › t-snare proteins 0.57 34.0 3.97e-01 71.1% 85.0%
3963743 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.57 37.0 3.91e-01 86.8% 72.4%
3646792 4177.1.1.0 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like 0.56 41.0 3.41e-01 76.3% 57.6%
3801607 150.1.1.121 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › PF29123 0.56 40.0 3.65e-01 74.6% 65.3%
3856031 192.29.1.0 ↗ alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) 0.55 38.0 3.77e-01 80.7% 66.4%
4149728 547.1.1.1 ↗ alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer 0.54 37.0 4.17e-01 95.6% 100.0%
4946446 5059.1.1.0 ↗ alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter 0.54 46.0 4.03e-01 92.1% 78.2%
3174810 630.1.1.4 ↗ a+b complex topology › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain › RuBisCo LSMT C-terminal, substrate-binding domain › PF28952 0.53 32.0 2.86e-01 79.8% 40.0%
5083960 1075.1.2.1 ↗ alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain › FtsX 0.52 42.0 3.60e-01 87.7% 92.1%
3256763 192.4.1.0 ↗ alpha bundles › Long alpha-hairpin › Ribosomal protein L29 (L29p) › Ribosomal protein L29 (L29p) 0.52 42.0 4.02e-01 88.6% 79.3%
3927597 604.3.1.0 ↗ alpha bundles › Spectrin repeat-like › BAG domain › BAG domain 0.52 39.0 3.87e-01 79.8% 81.7%
3944323 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.52 37.0 3.96e-01 79.8% 87.0%
5053834 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.51 41.0 3.61e-01 86.8% 81.2%
3560925 604.1.1.20 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › AKNA 0.50 37.0 3.81e-01 78.9% 82.7%