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thymidine_kinase
Euk-VirTestudinid_alphaherpesvirus_3
thymidine_kinase__YP_009176915__Testudinid_alphaherpesvirus_3__2560801
Identity
- Accession:
- YP_009176915 ↗
- Protein ID:
- thymidine_kinase
- Kingdom:
- euk
Quality
84.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Scutavirus›
Testudinid_alphaherpesvirus_3
TaxID: 2560801
Cluster
View cluster (35 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 31-137_317-351
Domain cluster:
rep: thymidine_kinase__YP_009230154__Leporid_alphaherpesvirus_4__481315__D1-149_256-295
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00693.25 best | Herpes_TK | 59.9 | 3.50e-16 | 84.5% | 39.3% |
CATH (16)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1osnC00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.86 | 80.0 | 5.93e-01 | 96.5% | 94.9% |
| 1e2jA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.85 | 81.0 | 6.05e-01 | 99.3% | 94.8% |
| 1p72A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.83 | 80.0 | 5.87e-01 | 100.0% | 94.4% |
| 3anwB00 | 1.20.58.2050 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.67 | 34.0 | 3.24e-01 | 82.4% | 41.4% |
| 1hqoA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.66 | 38.0 | 3.94e-01 | 83.8% | 60.3% |
| 4kb2A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.65 | 36.0 | 4.06e-01 | 80.3% | 69.7% |
| 4l8eA02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.58 | 30.0 | 3.33e-01 | 83.1% | 60.9% |
| 3cexA00 | 1.20.120.450 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › dinb family like domain | 0.56 | 35.0 | 3.28e-01 | 93.0% | 50.6% |
| 1xzpA02 | 1.20.120.430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › tRNA modification GTPase MnmE domain 2 | 0.55 | 41.0 | 3.90e-01 | 77.5% | 95.2% |
| 1qsdA00 | 1.20.58.90 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 33.0 | 3.83e-01 | 82.4% | 84.3% |
| 2dnxA00 | 1.20.58.70 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.54 | 32.0 | 3.36e-01 | 82.4% | 61.5% |
| 4b7yD00 | 3.30.40.10 | Alpha Beta › 2-Layer Sandwich › Herpes Virus-1 › Zinc/RING finger domain, C3HC4 (zinc finger) | 0.54 | 29.0 | 3.44e-01 | 82.4% | 75.3% |
| 2jaeA03 | 1.20.1440.240 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.54 | 32.0 | 3.76e-01 | 84.5% | 83.2% |
| 5nl6B01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.53 | 32.0 | 3.42e-01 | 84.5% | 66.9% |
| 5awwY00 | 1.10.3370.10 | Mainly Alpha › Orthogonal Bundle › Preprotein translocase SecY subunit › SecY subunit domain | 0.52 | 37.0 | 2.67e-01 | 72.5% | 53.8% |
| 7ymiD01 | 1.20.85.10 | Mainly Alpha › Up-down Bundle › Photosynthetic Reaction Center, subunit M; domain 1 › Photosystem II protein D1-like | 0.51 | 33.0 | 3.06e-01 | 97.9% | 49.4% |
ECOD (11)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 9545 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.89 | 86.0 | 6.25e-01 | 100.0% | 94.6% |
| 9546 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.87 | 81.0 | 5.93e-01 | 96.5% | 94.8% |
| 1322887 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.84 | 80.0 | 5.99e-01 | 99.3% | 94.4% |
| 4945691 | 192.15.1.0 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains | 0.80 | 29.0 | 3.99e-01 | 76.8% | 62.5% |
| 4971500 | 192.15.1.0 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains | 0.75 | 33.0 | 3.56e-01 | 78.2% | 49.2% |
| 3619654 | 192.15.1.2 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Mod_r | 0.67 | 32.0 | 3.01e-01 | 76.1% | 36.6% |
| 3533245 | 192.15.1.2 ↗ | alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › Mod_r | 0.58 | 29.0 | 2.77e-01 | 76.1% | 39.4% |
| 3174758 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.55 | 40.0 | 3.71e-01 | 75.4% | 64.3% |
| 3789674 | 109.3.1.0 ↗ | alpha superhelices › Repetitive alpha hairpins › Ankyrin repeat › Ankyrin repeat | 0.55 | 35.0 | 3.01e-01 | 75.4% | 40.4% |
| 3277496 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.54 | 42.0 | 3.32e-01 | 82.4% | 83.4% |
| 5019397 | 5067.1.1.12 ↗ | alpha bundles › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › Multidrug efflux transporter AcrB transmembrane domain › UPF0014 | 0.52 | 37.0 | 3.24e-01 | 74.6% | 59.1% |
D2
medium
residues 138-316
Domain cluster:
rep: thymidina_kinase__YP_009664657__Bubaline_alphaherpesvirus_1__202910__D121-329
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00693.25 best | Herpes_TK | 106.0 | 3.00e-30 | 93.8% | 58.9% |
CATH (4)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1osnC00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.95 | 87.0 | 6.98e-01 | 100.0% | 54.0% |
| 1e2jA00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.92 | 79.0 | 6.40e-01 | 100.0% | 51.6% |
| 1p72A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.92 | 88.0 | 6.93e-01 | 100.0% | 54.5% |
| 3mgxB00 | 1.10.630.10 | Mainly Alpha › Orthogonal Bundle › Cytochrome p450 › Cytochrome P450 | 0.53 | 44.0 | 3.44e-01 | 89.4% | 69.8% |
ECOD (4)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 9546 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.95 | 88.0 | 6.89e-01 | 100.0% | 52.0% |
| 1322887 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.92 | 79.0 | 6.40e-01 | 100.0% | 51.6% |
| 9545 | 2004.1.1.52 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK | 0.92 | 88.0 | 6.87e-01 | 100.0% | 52.9% |
| 4990030 | 2004.1.1.0 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases | 0.76 | 43.0 | 3.98e-01 | 100.0% | 43.9% |