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thymidine_kinase

Euk-Vir

Leporid_alphaherpesvirus_4

thymidine_kinase__YP_009230154__Leporid_alphaherpesvirus_4__481315

Identity

Accession:: YP_009230154 ↗
Protein ID:: thymidine_kinase
Kingdom:: euk

Quality

90.3 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Leporid_alphaherpesvirus_4

TaxID: 481315

Cluster

View cluster (35 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 1-149_256-295

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00693.25 best	Herpes_TK	177.2	6.00e-52	85.7%	55.0%

CATH (12)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1e2jA00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.90	87.0	7.14e-01	98.9%	95.4%
1osnC00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.86	80.0	6.59e-01	96.8%	95.5%
1p72A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.85	82.0	6.63e-01	99.5%	95.0%
1p5zB00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.70	57.0	5.31e-01	84.7%	94.8%
1zm7B00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.63	51.0	5.10e-01	85.2%	86.9%
4bemJ00	1.20.120.610	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › lithium bound rotor ring of v- atpase	0.59	33.0	3.41e-01	90.5%	56.4%
6ln3A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.57	46.0	4.52e-01	84.7%	92.6%
1ly1A00	3.40.50.300	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases	0.54	35.0	3.82e-01	100.0%	77.6%
7bobA01	3.20.20.80	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases	0.50	41.0	3.37e-01	86.8%	94.1%
1kwgA01	3.20.20.80	Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases	0.50	40.0	3.21e-01	84.7%	86.8%
6i3mE01	1.20.120.420	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1	0.50	32.0	3.69e-01	76.2%	88.3%
2ww8A03	3.40.50.410	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › von Willebrand factor, type A domain	0.50	40.0	3.47e-01	85.2%	87.2%

ECOD (14)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1322887	2004.1.1.52 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK	0.90	87.0	7.14e-01	98.9%	95.1%
9545	2004.1.1.52 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK	0.90	86.0	6.89e-01	99.5%	95.2%
9546	2004.1.1.52 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Herpes_TK	0.86	81.0	6.53e-01	96.8%	95.4%
3753842	2004.1.1.70 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › dNK	0.69	57.0	5.33e-01	85.7%	88.9%
4032626	2004.1.1.70 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › dNK	0.65	54.0	5.25e-01	86.8%	93.3%
5060871	601.1.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin	0.63	41.0	4.93e-01	75.1%	98.4%
4457642	2004.1.1.79 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin	0.62	51.0	4.90e-01	86.8%	93.0%
5034778	2004.1.1.79 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › Thymidylate_kin	0.60	50.0	5.01e-01	85.7%	93.7%
4106843	316.1.1.43 ↗	a+b three layers › Nucleotidyltransferase-like › Nucleotidyltransferase › Nucleotidyltransferase › DUF294	0.53	31.0	3.42e-01	85.7%	69.3%
3596067	601.7.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › HEPN › Nucleotidyltransferase substrate binding subunit/domain	0.53	30.0	3.24e-01	87.3%	63.7%
3728552	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.53	32.0	4.03e-01	83.6%	99.1%
3375691	2004.1.1.94 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATP_bind_1	0.52	43.0	3.74e-01	86.2%	82.5%
3733599	2004.1.1.94 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATP_bind_1	0.52	42.0	3.55e-01	86.2%	77.9%
3883045	196.1.1.5 ↗	alpha bundles › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › Regulator of G-protein signaling, RGS › Las1	0.51	29.0	3.25e-01	86.2%	70.3%

D2 medium residues 150-255

PDB

Domain cluster: rep: thymidine_kinase,_partial__YP_009207083__Hawaiian_green_turtle_herpesvirus__70564__D216-317

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF00693.25 best	Herpes_TK	50.6	2.40e-13	52.8%	18.6%