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thymidylate_synthase

Euk-Vir

Micromonas_pusilla_virus_12T

thymidylate_synthase__YP_007676112__Micromonas_pusilla_virus_12T__755272

Identity

Accession:
YP_007676112 ↗
Protein ID:
thymidylate_synthase
Kingdom:
euk

Quality

89.6 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Megaviricetes› Algavirales› Phycodnaviridae› Prasinovirus› Micromonas_pusilla_virus_12T

TaxID: 755272

Cluster

View cluster (33 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 2-92_163-219
PDB
Domain cluster: rep: IMGVR_UViG_3300025156_000428-3300025156-Ga0209834_1000016635__D1-193
Pfam (2)
AccessionNameScoreE-valueQ covHMM cov
PF02511.21 best Thy1 67.9 1.40e-18 56.8% 46.1%
PF02511.21 Thy1 57.6 2.00e-15 33.1% 24.6%
D2 high residues 107-158
PDB
Domain cluster: representative
CATH (9)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1kq4A00 3.30.1360.170 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.85 60.0 3.94e-01 75.0% 22.2%
4p5aC00 3.30.1360.170 Alpha Beta › 2-Layer Sandwich › Gyrase A; domain 2 › 0.77 68.0 4.45e-01 100.0% 24.2%
2m8gX00 1.10.10.60 Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Homeodomain-like 0.65 42.0 3.77e-01 76.9% 48.6%
1rqgA04 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.65 49.0 3.56e-01 82.7% 33.1%
3kksB00 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.62 52.0 3.84e-01 98.1% 45.4%
3v9rB00 1.10.20.10 Mainly Alpha › Orthogonal Bundle › Histone, subunit A › Histone, subunit A 0.62 55.0 4.97e-01 100.0% 75.0%
5l3wA01 1.20.120.140 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › SRP54, nucleotide-binding domain 0.62 42.0 3.58e-01 71.2% 100.0%
7ue1B01 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.58 50.0 3.70e-01 100.0% 43.8%
1wkbA03 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.57 50.0 3.80e-01 98.1% 64.5%
ECOD (17)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4982008 842.1.1.1 ↗ a+b two layers › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thy1 0.88 60.0 3.92e-01 71.2% 18.5%
4933143 842.1.1.1 ↗ a+b two layers › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thy1 0.85 61.0 3.96e-01 75.0% 19.7%
5066566 842.1.1.1 ↗ a+b two layers › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thy1 0.85 61.0 3.88e-01 75.0% 19.5%
4955043 842.1.1.1 ↗ a+b two layers › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thy1 0.85 58.0 4.07e-01 73.1% 24.7%
3790037 109.4.1.1946 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_2, TPR_8, TPR_12 0.83 54.0 3.21e-01 71.2% 10.8%
5069296 842.1.1.1 ↗ a+b two layers › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thy1 0.82 56.0 3.52e-01 75.0% 14.5%
4938196 5054.1.1.6 ↗ alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › TrkH 0.79 54.0 4.26e-01 71.2% 36.2%
4102574 842.1.1.1 ↗ a+b two layers › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thymidylate synthase-complementing protein Thy1 › Thy1 0.77 69.0 4.29e-01 100.0% 20.4%
3741803 109.4.1.3069 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_1, ANAPC3, TPR_8, TPR_17, TPR_16 0.77 61.0 3.44e-01 84.6% 9.1%
4779949 210.1.4.1 ↗ a+b four layers › Ntn/PP2C › Ntn › (Glycosyl)asparaginase › Asparaginase_2 0.72 54.0 3.82e-01 80.8% 26.8%
3940179 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.65 58.0 3.93e-01 100.0% 41.1%
5037828 4333.1.1.1 ↗ a+b complex topology › DNA methylase specificity domain › DNA methylase specificity domain › DNA methylase specificity domain › Methylase_S 0.65 51.0 3.41e-01 88.5% 90.7%
3576247 2003.1.5.66 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_11 0.65 46.0 2.98e-01 82.7% 15.4%
3881042 621.1.1.0 ↗ alpha bundles › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain › Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain 0.64 57.0 4.13e-01 100.0% 42.1%
957543 2487.1.1.8 ↗ a/b three-layered sandwiches › "The ""swivelling"" beta/beta/alpha domains" › "The ""swivelling"" beta/beta/alpha domain" › "The ""swivelling"" beta/beta/alpha domain" › RraA-like 0.58 51.0 3.34e-01 100.0% 87.9%
5058736 140.1.1.15 ↗ alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › tRNA-synt_1g 0.56 50.0 3.25e-01 100.0% 39.5%
2845167 3544.1.1.1 ↗ extended segments › Small envelope protein M › Small envelope protein M › Small envelope protein M › Flavi_M 0.51 41.0 3.83e-01 100.0% 90.3%