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thymidylate_synthase
Euk-VirEquid_gammaherpesvirus_5
thymidylate_synthase__YP_009118461__Equid_gammaherpesvirus_5__10371
Identity
- Accession:
- YP_009118461 ↗
- Protein ID:
- thymidylate_synthase
- Kingdom:
- euk
Quality
96.9
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Percavirus›
Equid_gammaherpesvirus_5
TaxID: 10371
Cluster
View cluster (52 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 27-51_225-289
Domain cluster:
rep: thymidylate_synthase__YP_009342120__Lymphocystis_disease_virus_Sa__1898060__D1-35_226-286
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 74.9 | 8.30e-21 | 73.3% | 24.9% |
D2
medium
residues 52-69_134-224
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 153.7 | 7.80e-45 | 85.3% | 34.3% |
CATH (59)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1tisA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.98 | 96.0 | 6.67e-01 | 100.0% | 57.3% |
| 1bo7A00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.98 | 95.0 | 6.47e-01 | 100.0% | 64.2% |
| 1bkpA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.97 | 94.0 | 6.64e-01 | 100.0% | 55.8% |
| 3v8hC00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.95 | 93.0 | 6.47e-01 | 100.0% | 82.3% |
| 1b5eA00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.91 | 86.0 | 6.43e-01 | 100.0% | 66.0% |
| 3egyX00 | 3.30.572.10 | Alpha Beta › 2-Layer Sandwich › Thymidylate Synthase; Chain A › Thymidylate synthase/dCMP hydroxymethylase domain | 0.90 | 87.0 | 6.49e-01 | 100.0% | 52.6% |
| 2rrlA01 | 3.30.750.140 | Alpha Beta › 2-Layer Sandwich › Transcription Regulator spoIIAA › | 0.72 | 52.0 | 5.16e-01 | 93.6% | 72.2% |
| 6hcdD00 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.67 | 40.0 | 3.76e-01 | 89.9% | 48.1% |
| 4hlbA00 | 3.30.70.2960 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › | 0.63 | 42.0 | 4.47e-01 | 78.0% | 76.8% |
| 4l4qA02 | 3.30.300.340 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › S-adenosylmethionine synthetase, N-terminal domain | 0.61 | 45.0 | 4.34e-01 | 78.0% | 70.9% |
| 3bypA00 | 3.30.70.1350 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cation efflux protein, cytoplasmic domain | 0.61 | 41.0 | 4.58e-01 | 74.3% | 91.5% |
| 3h90A02 | 3.30.70.1350 | Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › Cation efflux protein, cytoplasmic domain | 0.58 | 39.0 | 4.28e-01 | 70.6% | 86.9% |
| 5o5jC01 | 3.30.300.20 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain | 0.58 | 39.0 | 4.18e-01 | 74.3% | 82.2% |
| 3w6sC00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.58 | 48.0 | 3.85e-01 | 91.7% | 68.6% |
| 3tufA00 | 1.10.287.4300 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Stage III sporulation protein AH-like | 0.57 | 36.0 | 3.54e-01 | 75.2% | 58.3% |
| 1uwvA03 | 2.40.50.1070 | Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › | 0.57 | 40.0 | 3.71e-01 | 71.6% | 75.9% |
| 6nqbC01 | 3.30.300.20 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain | 0.57 | 38.0 | 4.13e-01 | 74.3% | 82.4% |
| 1vehA01 | 3.30.300.130 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › Fe-S cluster assembly (FSCA) | 0.57 | 37.0 | 4.25e-01 | 76.1% | 96.0% |
| 2cxcA02 | 3.30.300.20 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain | 0.57 | 35.0 | 4.12e-01 | 79.8% | 97.1% |
| 2l72A00 | 3.40.20.10 | Alpha Beta › 3-Layer(aba) Sandwich › Severin › Severin | 0.56 | 48.0 | 4.69e-01 | 93.6% | 89.0% |
| 1i12D00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.56 | 47.0 | 4.18e-01 | 90.8% | 82.2% |
| 4ftfA00 | 3.30.300.250 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › | 0.56 | 39.0 | 3.91e-01 | 74.3% | 70.6% |
| 3igrA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.56 | 47.0 | 3.97e-01 | 91.7% | 71.6% |
| 2kzfA00 | 3.30.300.20 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › K homology (KH) domain | 0.56 | 39.0 | 3.98e-01 | 71.6% | 83.0% |
| 6s2vC02 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.56 | 40.0 | 3.67e-01 | 74.3% | 86.9% |
| 3rpjA00 | 3.30.310.230 | Alpha Beta › 2-Layer Sandwich › TATA-Binding Protein › Sigma factor-binding protein Crl monomer | 0.56 | 44.0 | 4.26e-01 | 86.2% | 88.9% |
| 4ua3A00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.56 | 47.0 | 3.97e-01 | 92.7% | 68.8% |
| 4nxyA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.55 | 47.0 | 3.99e-01 | 91.7% | 76.1% |
| 1xf8A02 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.55 | 49.0 | 4.26e-01 | 98.2% | 74.5% |
| 3q6aB00 | 3.30.530.20 | Alpha Beta › 2-Layer Sandwich › Alpha-D-Glucose-1,6-Bisphosphate; Chain A, domain 4 › START domain | 0.55 | 43.0 | 4.02e-01 | 83.5% | 73.9% |
| 4u5pA00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.55 | 39.0 | 3.62e-01 | 74.3% | 70.0% |
| 7ovuA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.54 | 46.0 | 3.82e-01 | 92.7% | 69.9% |
| 3n54B03 | 3.30.300.210 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › Nutrient germinant receptor protein C, domain 3 | 0.54 | 41.0 | 3.81e-01 | 82.6% | 97.2% |
| 3tt2A00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.54 | 46.0 | 3.33e-01 | 94.5% | 37.1% |
| 2qmlA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.54 | 46.0 | 3.86e-01 | 95.4% | 67.9% |
| 2i79D00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.54 | 44.0 | 3.84e-01 | 89.9% | 73.1% |
| 4wd1A02 | 3.30.300.30 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › ANL, C-terminal domain | 0.53 | 36.0 | 3.46e-01 | 78.9% | 58.6% |
| 6wqbA02 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.53 | 46.0 | 4.24e-01 | 95.4% | 87.9% |
| 2bueA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.53 | 45.0 | 3.84e-01 | 93.6% | 73.2% |
| 3fbuA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.53 | 44.0 | 3.88e-01 | 91.7% | 70.5% |
| 1ufhA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.53 | 44.0 | 3.90e-01 | 89.9% | 81.3% |
| 3g8wB00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.53 | 44.0 | 3.81e-01 | 89.9% | 69.5% |
| 1vkcA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.52 | 43.0 | 4.02e-01 | 89.9% | 86.3% |
| 7r3bE01 | 3.30.300.10 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › | 0.52 | 37.0 | 4.10e-01 | 77.1% | 96.3% |
| 3c6vA00 | 3.30.429.10 | Alpha Beta › 2-Layer Sandwich › Macrophage Migration Inhibitory Factor › Macrophage Migration Inhibitory Factor | 0.52 | 38.0 | 3.49e-01 | 75.2% | 64.3% |
| 2fiaB00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.52 | 42.0 | 3.73e-01 | 87.2% | 71.7% |
| 2ganA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.52 | 43.0 | 3.95e-01 | 89.9% | 100.0% |
| 1x99A00 | 2.60.270.20 | Mainly Beta › Sandwich › Mutm (Fpg) Protein; Chain: A, domain 2 › Cytolysin/lectin | 0.52 | 43.0 | 3.90e-01 | 89.0% | 89.7% |
| 2q7bA00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.52 | 44.0 | 3.88e-01 | 93.6% | 73.2% |
| 1ib8A01 | 3.30.300.70 | Alpha Beta › 2-Layer Sandwich › GMP Synthetase; Chain A, domain 3 › RimP-like superfamily, N-terminal | 0.52 | 36.0 | 3.94e-01 | 71.6% | 94.0% |
| 2pdoA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.51 | 42.0 | 4.10e-01 | 89.9% | 84.7% |
| 6wqbA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.51 | 42.0 | 3.83e-01 | 89.9% | 73.0% |
| 1u0kA01 | 3.10.310.10 | Alpha Beta › Roll › Diaminopimelate Epimerase; Chain A, domain 1 › Diaminopimelate Epimerase; Chain A, domain 1 | 0.51 | 39.0 | 3.70e-01 | 97.2% | 67.4% |
| 4ga6A02 | 1.20.970.50 | Mainly Alpha › Up-down Bundle › Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3 › | 0.51 | 41.0 | 3.72e-01 | 87.2% | 63.2% |
| 5ib0A00 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.51 | 42.0 | 3.92e-01 | 89.9% | 77.4% |
| 3dddA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.51 | 42.0 | 4.02e-01 | 91.7% | 85.4% |
| 2f9zC00 | 3.30.1330.200 | Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › | 0.51 | 35.0 | 3.17e-01 | 89.9% | 50.6% |
| 4at7B02 | 3.30.460.10 | Alpha Beta › 2-Layer Sandwich › Beta Polymerase; domain 2 › Beta Polymerase, domain 2 | 0.50 | 36.0 | 3.05e-01 | 74.3% | 59.2% |
| 7b3aA01 | 3.40.630.30 | Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) | 0.50 | 43.0 | 3.94e-01 | 96.3% | 80.5% |
ECOD (94)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4664958 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 1.00 | 98.0 | 6.98e-01 | 100.0% | 58.0% |
| 2540892 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 1.00 | 98.0 | 6.56e-01 | 100.0% | 52.9% |
| 4151800 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 1.00 | 98.0 | 6.69e-01 | 100.0% | 62.8% |
| 4228846 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.99 | 97.0 | 6.54e-01 | 100.0% | 62.2% |
| 3944795 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.99 | 97.0 | 6.38e-01 | 100.0% | 67.0% |
| 4225236 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.99 | 97.0 | 6.75e-01 | 100.0% | 57.2% |
| 4108234 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.98 | 95.0 | 6.45e-01 | 100.0% | 64.7% |
| 5059575 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.97 | 95.0 | 6.60e-01 | 100.0% | 55.5% |
| 1900468 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.97 | 94.0 | 6.63e-01 | 100.0% | 55.6% |
| 4086625 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.96 | 93.0 | 6.55e-01 | 100.0% | 56.1% |
| 4937005 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.96 | 93.0 | 6.27e-01 | 100.0% | 54.9% |
| 3961326 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.96 | 77.0 | 6.16e-01 | 81.7% | 70.8% |
| 3164619 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.96 | 93.0 | 6.52e-01 | 100.0% | 58.3% |
| 3824671 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.96 | 93.0 | 6.54e-01 | 100.0% | 58.2% |
| 2028021 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.92 | 88.0 | 6.07e-01 | 100.0% | 48.7% |
| 4976145 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.92 | 88.0 | 6.69e-01 | 100.0% | 65.8% |
| 5015648 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.92 | 88.0 | 6.87e-01 | 100.0% | 66.3% |
| 4932636 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.92 | 88.0 | 6.76e-01 | 100.0% | 64.2% |
| 4949404 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 87.0 | 6.60e-01 | 100.0% | 60.4% |
| 5068964 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 88.0 | 6.17e-01 | 100.0% | 59.9% |
| 4582423 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 87.0 | 6.71e-01 | 100.0% | 59.6% |
| 5046158 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 87.0 | 6.88e-01 | 100.0% | 66.5% |
| 5031349 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.91 | 87.0 | 6.70e-01 | 100.0% | 65.1% |
| 4954631 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 86.0 | 6.52e-01 | 100.0% | 59.6% |
| 1900473 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 86.0 | 6.38e-01 | 100.0% | 64.6% |
| 5050802 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 86.0 | 6.12e-01 | 100.0% | 62.2% |
| 5022688 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 86.0 | 6.79e-01 | 100.0% | 65.8% |
| 4938917 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.90 | 85.0 | 6.34e-01 | 100.0% | 58.8% |
| 3955287 | 266.1.1.0 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase | 0.89 | 84.0 | 6.34e-01 | 100.0% | 65.1% |
| 5065331 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.87 | 83.0 | 6.37e-01 | 100.0% | 60.0% |
| 4998171 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.87 | 82.0 | 6.24e-01 | 100.0% | 58.7% |
| 5001950 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.85 | 80.0 | 5.95e-01 | 100.0% | 57.4% |
| 5005700 | 266.1.1.1 ↗ | a+b two layers › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylate synthase/dCMP hydroxymethylase › Thymidylat_synt | 0.82 | 77.0 | 6.44e-01 | 100.0% | 83.4% |
| 5053519 | 327.17.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › S-adenosylmethionine synthetase › S-adenosylmethionine synthetase › AdoMet_Synthase | 0.71 | 51.0 | 3.40e-01 | 75.2% | 61.1% |
| 5051076 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.65 | 42.0 | 4.85e-01 | 79.8% | 90.0% |
| 4975913 | 2008.1.1.220 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like › PDDEXK_10 | 0.65 | 35.0 | 3.40e-01 | 89.0% | 45.8% |
| 4975326 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.65 | 42.0 | 4.81e-01 | 77.1% | 90.0% |
| 5081027 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.64 | 41.0 | 4.74e-01 | 71.6% | 88.7% |
| 3285417 | 327.7.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like | 0.64 | 44.0 | 4.88e-01 | 73.4% | 90.6% |
| 5071431 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.63 | 40.0 | 4.69e-01 | 75.2% | 94.7% |
| 4447981 | 327.17.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › S-adenosylmethionine synthetase › S-adenosylmethionine synthetase › AdoMet_Synthase | 0.61 | 44.0 | 4.40e-01 | 75.2% | 75.7% |
| 3387384 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.61 | 40.0 | 4.41e-01 | 70.6% | 82.2% |
| 5011900 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.61 | 39.0 | 4.50e-01 | 71.6% | 93.3% |
| 3610560 | 327.7.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like | 0.60 | 39.0 | 3.87e-01 | 78.0% | 60.9% |
| 3385613 | 327.7.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like | 0.60 | 42.0 | 4.71e-01 | 73.4% | 97.6% |
| 3987655 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.60 | 39.0 | 4.28e-01 | 70.6% | 81.1% |
| 4007060 | 327.7.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like › ZT_dimer | 0.60 | 40.0 | 4.21e-01 | 71.6% | 76.8% |
| 3181542 | 207.1.1.33 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › DUF6546 | 0.60 | 42.0 | 2.93e-01 | 93.6% | 20.8% |
| 3277745 | 327.7.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like | 0.59 | 39.0 | 4.38e-01 | 78.0% | 90.0% |
| 3988381 | 327.7.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Cation efflux protein cytoplasmic domain-like › Cation efflux protein cytoplasmic domain-like | 0.59 | 42.0 | 4.46e-01 | 75.2% | 91.6% |
| 3925211 | 327.11.1.4 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › MRP-S24 | 0.59 | 41.0 | 3.76e-01 | 73.4% | 55.7% |
| 4191286 | 327.11.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) | 0.59 | 42.0 | 3.99e-01 | 74.3% | 80.8% |
| 3970458 | 327.2.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › BolA-like › BolA-like › BolA | 0.58 | 36.0 | 4.15e-01 | 74.3% | 89.3% |
| 3656918 | 213.1.1.1 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 | 0.58 | 48.0 | 3.73e-01 | 89.0% | 67.9% |
| 4002275 | 2003.1.5.53 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr | 0.58 | 45.0 | 3.02e-01 | 83.5% | 45.3% |
| 3290074 | 213.5.1.1 ↗ | a+b three layers › Nat/Ivy › AlkZ C-terminal domain › AlkZ C-terminal domain › AlkZ-like | 0.58 | 48.0 | 4.98e-01 | 89.9% | 96.0% |
| 4996269 | 844.1.1.0 ↗ | beta barrels › Transcriptional factor tubby, C-terminal domain › Transcriptional factor tubby, C-terminal domain › Transcriptional factor tubby, C-terminal domain | 0.58 | 49.0 | 3.92e-01 | 94.5% | 59.1% |
| 4458088 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.58 | 38.0 | 4.33e-01 | 74.3% | 92.5% |
| 4304131 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.57 | 39.0 | 3.87e-01 | 75.2% | 67.0% |
| 4977550 | 213.5.1.1 ↗ | a+b three layers › Nat/Ivy › AlkZ C-terminal domain › AlkZ C-terminal domain › AlkZ-like | 0.56 | 47.0 | 4.94e-01 | 89.9% | 96.0% |
| 3240027 | 2007.2.3.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Flavoproteins/Phosphotyrosine protein phosphatases-like › (Phosphotyrosine protein) phosphatases II › Y_phosphatase | 0.56 | 46.0 | 3.43e-01 | 87.2% | 36.9% |
| 4944041 | 2008.1.1.0 ↗ | a/b three-layered sandwiches › Restriction endonuclease-like › Restriction endonuclease-like › Restriction endonuclease-like | 0.56 | 38.0 | 3.41e-01 | 70.6% | 56.2% |
| 4243900 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.55 | 37.0 | 3.83e-01 | 74.3% | 71.4% |
| 3575946 | 213.1.1.25 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_3 | 0.55 | 47.0 | 3.93e-01 | 91.7% | 75.7% |
| 4060612 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.55 | 38.0 | 3.80e-01 | 75.2% | 67.0% |
| 5023294 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.55 | 38.0 | 4.17e-01 | 73.4% | 90.6% |
| 4114221 | 327.10.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Ribosome-binding factor A (RbfA)-related › Ribosome-binding factor A (RbfA)-related › RBFA | 0.55 | 38.0 | 3.81e-01 | 71.6% | 82.6% |
| 4092189 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.55 | 39.0 | 3.91e-01 | 74.3% | 73.9% |
| 3176969 | 224.1.1.1 ↗ | a+b three layers › Gelsolin-like › Gelsolin-like › Gelsolin-like › Cofilin_ADF | 0.55 | 44.0 | 4.36e-01 | 88.1% | 88.3% |
| 4075860 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.55 | 38.0 | 3.76e-01 | 75.2% | 67.0% |
| None | — | 0.55 | 43.0 | 2.96e-01 | 83.5% | 43.3% | |
| 4957434 | 213.5.1.1 ↗ | a+b three layers › Nat/Ivy › AlkZ C-terminal domain › AlkZ C-terminal domain › AlkZ-like | 0.55 | 43.0 | 4.64e-01 | 89.9% | 96.8% |
| 4961225 | 213.5.1.1 ↗ | a+b three layers › Nat/Ivy › AlkZ C-terminal domain › AlkZ C-terminal domain › AlkZ-like | 0.54 | 44.0 | 4.69e-01 | 89.0% | 98.9% |
| 4042773 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.54 | 38.0 | 3.87e-01 | 75.2% | 75.2% |
| 4112084 | 327.11.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) | 0.54 | 38.0 | 3.86e-01 | 75.2% | 75.2% |
| 3989509 | 7523.1.1.0 ↗ | a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II | 0.54 | 36.0 | 3.67e-01 | 88.1% | 68.2% |
| 4569386 | 327.11.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) | 0.53 | 38.0 | 3.59e-01 | 74.3% | 81.5% |
| 3787053 | 224.1.1.1 ↗ | a+b three layers › Gelsolin-like › Gelsolin-like › Gelsolin-like › Cofilin_ADF | 0.53 | 43.0 | 4.04e-01 | 89.9% | 86.4% |
| 2808671 | 213.1.1.1 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1 | 0.53 | 46.0 | 4.07e-01 | 95.4% | 77.8% |
| None | — | 0.53 | 42.0 | 2.88e-01 | 83.5% | 42.0% | |
| None | — | 0.53 | 42.0 | 2.88e-01 | 83.5% | 42.0% | |
| 3016757 | 213.1.1.7 ↗ | a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › FemAB | 0.53 | 47.0 | 4.04e-01 | 98.2% | 70.5% |
| 4519295 | 327.11.1.1 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) › KH_2 | 0.53 | 39.0 | 3.89e-01 | 78.0% | 81.7% |
| 4026432 | 327.4.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › YhbC-like, N-terminal domain › YhbC-like, N-terminal domain | 0.53 | 38.0 | 4.06e-01 | 76.1% | 94.7% |
| 4322533 | 327.11.1.0 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › KH-domains › Prokaryotic type KH domain (KH-domain type II) | 0.53 | 38.0 | 3.83e-01 | 75.2% | 74.5% |
| 4398555 | 327.10.1.2 ↗ | a+b two layers › Alpha-lytic protease prodomain-like › Ribosome-binding factor A (RbfA)-related › Ribosome-binding factor A (RbfA)-related › RBFA | 0.53 | 36.0 | 3.57e-01 | 71.6% | 75.0% |
| 4431551 | 2003.1.5.53 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr | 0.53 | 41.0 | 2.82e-01 | 83.5% | 43.1% |
| None | — | 0.52 | 41.0 | 2.85e-01 | 83.5% | 42.3% | |
| 4329458 | 2003.1.5.53 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr | 0.52 | 41.0 | 2.82e-01 | 83.5% | 42.3% |
| 4132035 | 2003.1.5.53 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr | 0.52 | 41.0 | 2.76e-01 | 83.5% | 37.8% |
| 5055279 | 1075.1.2.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type II ABC exporter transmembrane domain-related › MacB transmembrane domain | 0.52 | 44.0 | 3.51e-01 | 89.9% | 91.7% |
| 4297517 | 2003.1.5.156 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr, Methyltransf_31 | 0.52 | 40.0 | 2.76e-01 | 83.5% | 39.0% |
| 4055289 | 2003.1.5.156 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › tRNA_U5-meth_tr, Methyltransf_31 | 0.51 | 40.0 | 2.80e-01 | 83.5% | 42.8% |
| None | — | 0.51 | 40.0 | 2.76e-01 | 83.5% | 41.2% |
D3
medium
residues 70-133
Domain cluster:
rep: thymidylate_synthase__YP_010087878__Lymphocystis_disease_virus_4__2704413__D55-131
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00303.25 best | Thymidylat_synt | 37.0 | 3.10e-09 | 98.4% | 15.1% |