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topoisomerase_IIA

Euk-Vir

Pithovirus_sibericum

topoisomerase_IIA__YP_009001040__Pithovirus_sibericum__1450746

Identity

Accession:
YP_009001040 ↗
Protein ID:
topoisomerase_IIA
Kingdom:
euk

Quality

89.7 mean pLDDT

Cluster

View cluster (39 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 468-557_594-682
PDB
Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D385-517_553-621_640-664
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF16898.11 best TOPRIM_C 33.7 5.40e-08 53.1% 65.6%
D2 high residues 688-820
PDB
Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D669-796
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 88.6 6.00e-25 100.0% 28.8%
D3 high residues 1002-1104
PDB
Domain cluster: rep: KM209246.1__AIM51491.1__HQ82_0234__00002__D56-167
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 33.8 2.50e-08 100.0% 23.2%
CATH (76)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
8gccA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.93 81.0 8.09e-01 90.3% 100.0%
1bgwA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.91 74.0 7.26e-01 84.5% 100.0%
3qx3A04 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.90 72.0 7.31e-01 82.5% 100.0%
4abmD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.86 53.0 6.07e-01 97.1% 83.1%
3nvoB02 1.20.58.340 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Magnesium transport protein CorA, transmembrane region 0.82 52.0 5.03e-01 97.1% 57.8%
3qo8A01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.82 57.0 5.71e-01 96.1% 69.8%
4iloA00 1.10.287.1490 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.81 58.0 4.24e-01 97.1% 31.8%
1zvuA03 1.10.268.10 Mainly Alpha › Orthogonal Bundle › Topoisomerase; domain 3 › Topoisomerase, domain 3 0.81 75.0 6.72e-01 100.0% 80.0%
3hr0B01 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.80 53.0 6.01e-01 99.0% 88.6%
3lssA01 1.10.287.40 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Serine-tRNA synthetase, tRNA binding domain 0.78 57.0 5.56e-01 97.1% 69.6%
2dw4A03 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.77 60.0 6.10e-01 96.1% 81.2%
4hwdD00 1.20.58.120 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain 0.77 45.0 4.81e-01 94.2% 66.7%
1b06A01 1.10.287.990 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Fe,Mn superoxide dismutase (SOD) domain 0.76 46.0 5.65e-01 92.2% 94.0%
3ieeA02 1.20.58.820 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Uncharacterised protein PF12889, C-terminal DUF3829 0.75 46.0 4.64e-01 99.0% 61.2%
1lvfB00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.75 43.0 4.38e-01 96.1% 56.7%
2oduA02 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.75 49.0 4.90e-01 97.1% 64.8%
2qywA00 1.20.58.400 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins 0.74 48.0 5.01e-01 97.1% 70.5%
2fb5A01 1.10.287.770 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › YojJ-like 0.73 49.0 5.74e-01 100.0% 100.0%
1qv9A02 6.10.140.120 Special › Helix non-globular › Helix Hairpins › 0.73 45.0 4.60e-01 86.4% 63.1%
1e1dA02 1.20.1270.20 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.72 39.0 4.29e-01 87.4% 64.3%
3rx6A00 1.20.58.1090 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phage polarity suppression protein monomer 0.72 51.0 4.13e-01 97.1% 40.1%
4w4kA00 1.10.287.850 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HP0062-like domain 0.70 46.0 5.05e-01 100.0% 82.9%
2ot4A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.70 49.0 4.86e-01 93.2% 69.2%
1qsdA00 1.20.58.90 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.70 48.0 4.88e-01 98.1% 71.6%
1gvnA00 1.10.8.130 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.70 38.0 4.08e-01 88.3% 62.1%
3favD00 1.10.287.1060 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like 0.69 47.0 5.25e-01 97.1% 91.0%
1w9rA00 1.20.58.440 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › choline binding protein A 0.69 45.0 4.31e-01 93.2% 57.1%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.69 43.0 4.14e-01 93.2% 54.3%
2oezA02 1.10.3900.10 Mainly Alpha › Orthogonal Bundle › YacF-like › YacF-like 0.69 43.0 3.73e-01 99.0% 39.9%
6xkyA01 1.20.1330.10 Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain 0.69 62.0 5.02e-01 97.1% 85.6%
1hciA04 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.68 46.0 4.44e-01 97.1% 61.4%
3fppA03 6.10.140.1990 Special › Helix non-globular › Helix Hairpins › 0.68 54.0 5.84e-01 98.1% 97.7%
2hujA00 1.20.120.440 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › YppE-like 0.68 54.0 5.11e-01 85.4% 100.0%
2y39A00 1.20.120.1490 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › 0.68 46.0 4.59e-01 97.1% 66.4%
4d8mA01 1.20.190.10 Mainly Alpha › Up-down Bundle › Delta-Endotoxin; domain 1 › Pesticidal crystal protein, N-terminal domain 0.67 55.0 4.25e-01 97.1% 41.2%
2q0oC00 1.10.287.160 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat 0.67 46.0 4.92e-01 94.2% 83.7%
1fs0G02 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.66 54.0 5.79e-01 97.1% 98.9%
4aflA00 6.10.140.1740 Special › Helix non-globular › Helix Hairpins › 0.66 46.0 4.67e-01 97.1% 72.5%
1qkrB00 1.20.120.230 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like 0.65 45.0 3.71e-01 96.1% 40.0%
6p73A02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.64 43.0 3.83e-01 100.0% 49.7%
7b7tA01 1.20.1270.30 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.64 60.0 5.07e-01 100.0% 82.6%
2p5tA00 1.10.8.130 Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › 0.64 40.0 4.22e-01 92.2% 69.6%
1wcrA00 1.20.58.80 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphotransferase system, lactose/cellobiose-type IIA subunit 0.64 44.0 4.41e-01 93.2% 69.9%
6yz2A01 1.20.120.350 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Voltage-gated potassium channels. Chain C 0.63 41.0 3.86e-01 88.3% 55.0%
3m9vA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.63 51.0 4.36e-01 100.0% 55.4%
1qu7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.63 56.0 4.21e-01 100.0% 42.7%
2xubA05 6.10.140.1450 Special › Helix non-globular › Helix Hairpins › 0.63 50.0 5.24e-01 96.1% 90.6%
3vkgA12 1.10.287.2610 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.63 58.0 4.39e-01 96.1% 82.8%
3g9gA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.63 59.0 4.31e-01 100.0% 68.4%
4mh6A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.63 57.0 4.79e-01 99.0% 61.6%
2efkA01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.62 59.0 4.26e-01 100.0% 77.5%
2ch7A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.61 54.0 3.76e-01 100.0% 31.4%
1wpaA01 6.10.140.340 Special › Helix non-globular › Helix Hairpins › 0.61 47.0 4.79e-01 96.1% 84.8%
2i0mA01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.61 39.0 3.94e-01 90.3% 63.2%
1xwmA00 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.60 55.0 4.27e-01 98.1% 96.2%
8ex5A02 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.60 53.0 4.12e-01 97.1% 95.0%
2odvA01 1.20.58.60 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.60 44.0 4.32e-01 90.3% 71.4%
1i4dA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.59 55.0 4.44e-01 100.0% 79.8%
3k29A00 1.10.287.1700 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.59 55.0 4.66e-01 99.0% 68.9%
3kkbA00 1.20.120.880 Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase (KinB), sensor domain 0.59 53.0 4.97e-01 100.0% 98.4%
1kmiZ02 1.10.287.500 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin 0.58 53.0 4.82e-01 98.1% 77.6%
3g67A00 1.10.287.950 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Methyl-accepting chemotaxis protein 0.58 54.0 4.15e-01 100.0% 85.9%
4cgkA01 6.10.250.3150 Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › 0.58 52.0 4.04e-01 97.1% 50.9%
4im0A04 1.20.1270.420 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.57 53.0 3.98e-01 100.0% 70.6%
1kz7A01 1.20.900.10 Mainly Alpha › Up-down Bundle › Dbl Homology Domain; Chain A › Dbl homology (DH) domain 0.57 52.0 4.19e-01 100.0% 85.5%
6q45G01 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.56 51.0 4.54e-01 99.0% 83.6%
3zdqA01 1.20.1560.10 Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain 0.55 50.0 3.40e-01 96.1% 66.4%
8a1gC01 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.55 51.0 4.17e-01 100.0% 75.7%
3gi7A00 1.20.1270.180 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.55 40.0 4.00e-01 100.0% 74.8%
1gaxA05 1.10.287.380 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain 0.55 36.0 4.18e-01 98.1% 94.5%
1mabG00 1.10.287.80 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain 0.54 49.0 4.58e-01 97.1% 80.6%
2m6bA00 1.20.58.390 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Neurotransmitter-gated ion-channel transmembrane domain 0.54 46.0 4.13e-01 96.1% 96.7%
3ousA00 1.10.287.70 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › 0.54 39.0 4.25e-01 93.2% 93.9%
1oahA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.54 43.0 3.81e-01 82.5% 84.5%
4fzsA00 1.20.1270.60 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain 0.54 48.0 3.83e-01 100.0% 83.7%
3kavA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.51 46.0 4.69e-01 97.1% 99.0%
ECOD (77)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3328306 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.96 93.0 7.29e-01 100.0% 75.3%
3652359 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.96 92.0 7.54e-01 100.0% 67.1%
3718739 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 92.0 7.57e-01 100.0% 78.8%
3789604 4016.1.1.0 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.95 91.0 7.83e-01 100.0% 80.7%
3625174 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 91.0 6.94e-01 100.0% 74.8%
3276180 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 91.0 7.11e-01 100.0% 77.4%
3634044 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 91.0 7.15e-01 100.0% 74.2%
3610015 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.95 91.0 7.50e-01 100.0% 75.2%
3600354 4016.1.1.0 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase 0.94 90.0 7.72e-01 100.0% 72.0%
3708939 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.93 89.0 7.56e-01 100.0% 69.7%
3935542 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 88.0 7.57e-01 100.0% 75.3%
3768919 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 88.0 6.04e-01 100.0% 47.7%
3267708 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 88.0 7.64e-01 100.0% 80.0%
3508111 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 87.0 7.03e-01 100.0% 82.2%
3630114 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.92 87.0 7.61e-01 100.0% 83.4%
4238706 101.1.2.9 ↗ alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.92 87.0 5.99e-01 100.0% 46.2%
4878008 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.91 87.0 8.13e-01 100.0% 87.6%
3220667 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.91 86.0 7.76e-01 100.0% 87.4%
4830953 101.1.2.9 ↗ alpha arrays › HTH › HTH › winged helix domain › DNA_topoisoIV 0.90 85.0 7.00e-01 100.0% 69.4%
4452951 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 85.0 6.95e-01 100.0% 76.6%
2443871 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.90 85.0 7.08e-01 100.0% 80.1%
3763261 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.88 56.0 4.17e-01 96.1% 30.0%
3557114 604.1.1.66 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_1st_PEPL 0.84 49.0 4.85e-01 96.1% 55.5%
3671258 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.83 59.0 5.33e-01 97.1% 56.9%
1297277 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.82 76.0 6.22e-01 100.0% 63.0%
3216584 632.1.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Families 57/38 glycoside transferase middle domain › Families 57/38 glycoside transferase middle domain 0.82 48.0 5.07e-01 98.1% 64.2%
4373100 4016.1.1.1 ↗ alpha bundles › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › alpha-helical domain in type II DNA topoisomerase › DNA_topoisoIV 0.82 75.0 6.67e-01 100.0% 78.6%
3389507 3817.1.1.1 ↗ alpha bundles › Peroxisomal biogenesis factor 19 › Peroxisomal biogenesis factor 19 › Peroxisomal biogenesis factor 19 › Pex19 0.81 48.0 4.53e-01 95.1% 50.8%
3828 604.6.1.1 ↗ alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › GAT 0.77 53.0 5.13e-01 95.1% 64.3%
4246573 3755.1.1.8 ↗ alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › FliJ 0.77 58.0 4.96e-01 96.1% 53.3%
4984240 2004.1.1.87 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.76 57.0 3.46e-01 96.1% 14.1%
3763195 1072.1.1.1 ↗ alpha bundles › Hsp90 co-chaperone Cdc37 N-terminal domain › Hsp90 co-chaperone Cdc37 N-terminal domain › Hsp90 co-chaperone Cdc37 N-terminal domain › CDC37_N 0.76 58.0 5.18e-01 96.1% 60.0%
3240456 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.75 43.0 4.67e-01 96.1% 68.2%
3810014 3291.1.1.0 ↗ alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related 0.73 67.0 6.12e-01 96.1% 79.1%
3615972 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.72 58.0 4.62e-01 96.1% 46.5%
3553221 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.71 48.0 4.54e-01 100.0% 58.3%
3892492 604.1.1.66 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_1st_PEPL 0.71 47.0 4.62e-01 97.1% 62.7%
3605635 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.71 58.0 5.39e-01 97.1% 70.4%
5023098 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.71 55.0 5.12e-01 100.0% 67.2%
3408277 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.69 59.0 5.68e-01 96.1% 79.1%
4045132 192.8.1.0 ↗ alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain 0.66 54.0 5.28e-01 97.1% 80.0%
3935140 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.65 59.0 4.71e-01 97.1% 53.3%
3404270 377.1.1.0 ↗ few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like 0.65 41.0 3.80e-01 100.0% 50.8%
4516988 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.64 59.0 5.18e-01 97.1% 70.0%
3221921 3939.1.1.0 ↗ alpha duplicates or obligate multimers › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain › XRCC4 C-terminal oligomerization domain 0.64 58.0 5.95e-01 96.1% 98.0%
4395939 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.63 57.0 4.20e-01 97.1% 71.0%
3943069 3291.1.1.136 ↗ alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › PF27688 0.63 55.0 4.92e-01 100.0% 69.6%
3235302 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.63 58.0 4.19e-01 96.1% 47.8%
3610147 3755.1.1.0 ↗ alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related 0.63 58.0 4.83e-01 96.1% 92.1%
3473587 604.1.1.0 ↗ alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.62 48.0 4.46e-01 96.1% 65.6%
4982777 3291.1.1.238 ↗ alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › DUF7121 0.62 55.0 4.09e-01 92.2% 68.7%
4629385 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.62 58.0 4.96e-01 100.0% 66.7%
5081955 3834.1.1.25 ↗ alpha bundles › TcA alpha pore-forming domain › TcA alpha pore-forming domain › TcA alpha pore-forming domain › DUF7121 0.62 57.0 4.03e-01 96.1% 71.5%
3595868 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.62 57.0 4.01e-01 97.1% 47.7%
3235839 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.62 59.0 4.79e-01 100.0% 94.3%
3385272 2004.1.1.87 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.62 56.0 3.20e-01 96.1% 25.8%
3699458 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.61 57.0 3.99e-01 97.1% 36.1%
5084060 3755.3.1.637 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › DUF7121 0.61 52.0 4.43e-01 88.3% 100.0%
4994917 3834.1.1.25 ↗ alpha bundles › TcA alpha pore-forming domain › TcA alpha pore-forming domain › TcA alpha pore-forming domain › DUF7121 0.61 56.0 4.13e-01 97.1% 90.6%
3858356 632.22.1.0 ↗ alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats 0.61 55.0 4.85e-01 96.1% 97.2%
3408532 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.60 55.0 4.54e-01 96.1% 96.5%
3589462 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.60 56.0 4.38e-01 97.1% 51.8%
1291200 4177.1.1.1 ↗ alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like › FCH 0.60 57.0 3.98e-01 100.0% 72.8%
4988997 192.2.1.0 ↗ alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin 0.60 48.0 3.95e-01 96.1% 48.3%
3990182 3922.1.1.226 ↗ alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Fy-3 0.60 51.0 4.94e-01 100.0% 80.9%
3782183 219.1.1.0 ↗ a+b complex topology › Cysteine proteinases-like › Cysteine proteinases › Cysteine proteinases 0.60 57.0 3.58e-01 100.0% 22.8%
4989878 2004.1.1.87 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.60 55.0 3.32e-01 97.1% 50.3%
3255893 5050.1.1.9 ↗ alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.59 50.0 3.93e-01 92.2% 85.8%
3856852 310.2.1.19 ↗ a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF › RasGAP_C 0.58 44.0 4.28e-01 92.2% 71.3%
3743191 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.57 48.0 3.91e-01 98.1% 49.5%
4324117 3755.4.1.0 ↗ alpha bundles › YscO-like › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain › Phosphatidylinositol 3-kinase regulatory subunit inter-SH2 domain 0.55 49.0 3.36e-01 97.1% 42.3%
3930816 101.1.2.236 ↗ alpha arrays › HTH › HTH › winged helix domain › POLR3C_WHD 0.55 49.0 3.54e-01 96.1% 37.1%
4571188 3755.3.1.0 ↗ alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin 0.54 42.0 3.96e-01 98.1% 66.9%
3971049 3755.1.1.0 ↗ alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related 0.53 48.0 3.46e-01 100.0% 35.9%
4500042 2004.1.1.87 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › SMC_N 0.53 47.0 3.01e-01 96.1% 22.8%
3424514 606.1.1.0 ↗ alpha complex topology › Nop N-terminal domain › Nop N-terminal domain › Nop N-terminal domain 0.52 46.0 4.42e-01 98.1% 85.0%
3957443 5086.1.1.0 ↗ alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins 0.52 46.0 4.23e-01 100.0% 76.9%
D4 medium residues 13-28_57-71_84-210
PDB
Domain cluster: rep: GyrB-like_ATPase_domain_protein__YP_784274__Nile_crocodilepox_virus__1285600__D74-178
D5 medium residues 29-56_72-83_211-249
PDB
Domain cluster: representative
CATH (3)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
5c82A00 3.40.630.30 Alpha Beta › 3-Layer(aba) Sandwich › Aminopeptidase › Gcn5-related N-acetyltransferase (GNAT) 0.56 45.0 3.54e-01 88.6% 84.1%
2b9dA01 3.30.160.330 Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › 0.53 27.0 3.57e-01 84.8% 97.4%
4ivkA00 3.40.710.10 Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily 0.51 39.0 2.50e-01 83.5% 40.1%
ECOD (4)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3217805 386.1.1.366 ↗ few secondary structure elements › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › beta-beta-alpha zinc fingers › BPTI_nem 0.51 34.0 3.43e-01 89.9% 67.5%
3212167 5001.1.1.41 ↗ alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srw 0.51 37.0 2.43e-01 75.9% 84.1%
3291254 2004.1.1.286 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › TraG-D_C 0.51 41.0 2.50e-01 87.3% 35.1%
3885857 223.1.1.0 ↗ a+b three layers › Profilin-like › sensor domains › sensor domains 0.51 32.0 3.34e-01 92.4% 68.0%
D6 medium residues 250-321_335-390
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00204.32 best DNA_gyraseB 41.4 1.50e-10 90.6% 56.3%
CATH (20)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1qzrA02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.88 76.0 7.78e-01 89.1% 92.7%
3lnuA02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.85 80.0 7.36e-01 100.0% 90.7%
4hy1A02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.83 79.0 7.26e-01 100.0% 90.5%
3zkbI02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.83 78.0 7.17e-01 100.0% 87.5%
3cwvA02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.81 75.0 7.09e-01 100.0% 93.4%
1z5bB03 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.67 61.0 5.83e-01 99.2% 91.3%
1y6zA01 3.30.230.80 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.59 51.0 4.77e-01 100.0% 76.3%
1xhkA00 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.56 44.0 3.90e-01 83.6% 58.4%
2wp8B00 3.30.230.70 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain 0.56 42.0 3.51e-01 87.5% 46.1%
2drhB00 3.60.70.12 Alpha Beta › 4-Layer Sandwich › L-amino peptidase D-ALA esterase/amidase › L-amino peptidase D-ALA esterase/amidase 0.55 49.0 3.61e-01 98.4% 85.0%
8eilD01 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.55 39.0 3.57e-01 87.5% 55.3%
6n10A01 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.53 45.0 3.86e-01 91.4% 69.9%
2hfsA01 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.52 42.0 3.82e-01 87.5% 68.7%
1e3hA03 3.30.230.70 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain 0.52 44.0 3.73e-01 91.4% 56.3%
5lvxC02 2.60.40.1180 Mainly Beta › Sandwich › Immunoglobulin-like › Golgi alpha-mannosidase II 0.52 27.0 2.93e-01 71.9% 54.6%
3qh4A00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.51 40.0 3.05e-01 82.8% 60.8%
1nztA01 3.30.230.20 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › lpxc deacetylase, domain 1 0.51 43.0 4.46e-01 96.1% 99.2%
2nn6B01 3.30.230.70 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain 0.50 41.0 3.49e-01 89.8% 54.1%
2qtsA02 2.60.470.10 Mainly Beta › Sandwich › Acid-sensing ion channels like fold › Acid-sensing ion channels like domains 0.50 36.0 3.23e-01 73.4% 84.8%
2nn6C00 3.30.230.70 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › GHMP Kinase, N-terminal domain 0.50 44.0 3.47e-01 96.1% 54.1%
ECOD (60)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4641709 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.89 85.0 7.40e-01 100.0% 83.9%
3433616 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.88 84.0 7.71e-01 100.0% 86.3%
3585145 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.88 84.0 7.64e-01 100.0% 86.3%
3799215 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.88 84.0 7.55e-01 100.0% 83.6%
3513708 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.87 83.0 7.62e-01 100.0% 86.3%
3275256 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.87 83.0 7.42e-01 100.0% 85.9%
4000834 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.87 83.0 7.49e-01 100.0% 86.1%
4234522 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 82.0 7.33e-01 100.0% 87.1%
4027043 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 81.0 7.20e-01 100.0% 85.7%
3967155 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 81.0 7.20e-01 100.0% 84.0%
3964340 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 81.0 7.05e-01 100.0% 83.2%
4261801 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 81.0 6.97e-01 100.0% 80.5%
4380841 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 81.0 7.18e-01 100.0% 83.4%
3807571 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 81.0 7.16e-01 100.0% 84.0%
4298571 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.86 81.0 7.02e-01 100.0% 83.2%
3594648 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.85 81.0 7.43e-01 100.0% 83.7%
4288775 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.85 81.0 7.08e-01 100.0% 83.9%
4945732 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.85 80.0 7.13e-01 100.0% 85.1%
3970715 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.85 80.0 7.13e-01 100.0% 84.6%
4040519 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.85 80.0 7.27e-01 100.0% 81.2%
3220683 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.85 81.0 7.32e-01 100.0% 84.2%
4207771 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.85 80.0 7.10e-01 100.0% 84.0%
4339883 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.83 79.0 6.83e-01 100.0% 87.0%
1388837 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.81 77.0 7.30e-01 100.0% 93.2%
341211 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.80 75.0 7.07e-01 100.0% 93.4%
2630700 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.74 37.0 5.19e-01 73.4% 100.0%
4160946 212.1.1.9 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_mis_repair 0.72 55.0 5.95e-01 93.0% 93.6%
5033236 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.72 65.0 4.75e-01 98.4% 43.0%
4028943 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.71 65.0 5.42e-01 100.0% 70.0%
4018662 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.69 60.0 5.61e-01 94.5% 96.9%
4584919 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.69 62.0 5.34e-01 98.4% 69.5%
4972803 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.69 62.0 5.32e-01 98.4% 69.5%
4941612 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.68 62.0 5.10e-01 99.2% 60.9%
3635746 212.1.1.9 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_mis_repair 0.68 59.0 5.50e-01 93.8% 96.9%
4966371 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.68 62.0 4.65e-01 100.0% 45.6%
5023191 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.67 61.0 5.53e-01 98.4% 74.1%
4957148 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.66 59.0 5.11e-01 98.4% 70.5%
5081565 212.1.1.3 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N 0.64 51.0 4.44e-01 84.4% 73.7%
4121983 212.1.1.6 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal_S9 0.64 46.0 3.81e-01 88.3% 43.2%
3991620 212.1.1.25 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › MVD-like_N 0.60 48.0 4.12e-01 85.2% 75.6%
4986390 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.60 46.0 5.03e-01 89.8% 100.0%
3288171 212.1.1.3 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N 0.60 49.0 4.42e-01 86.7% 72.9%
None — 0.59 47.0 4.12e-01 85.2% 73.0%
4993863 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.58 47.0 4.98e-01 88.3% 99.1%
4947776 212.1.1.20 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Fae 0.58 50.0 4.67e-01 91.4% 92.9%
3436776 330.1.1.0 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like 0.58 25.0 2.79e-01 71.1% 48.0%
4014103 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.57 45.0 3.92e-01 82.0% 73.2%
None — 0.57 45.0 4.01e-01 82.8% 74.4%
3961185 212.1.1.3 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N 0.57 47.0 4.02e-01 87.5% 65.0%
3270230 212.1.1.17 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › EFG_IV 0.57 48.0 4.74e-01 90.6% 98.5%
3641225 212.1.1.25 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › MVD-like_N 0.57 46.0 4.42e-01 85.2% 100.0%
4078116 212.1.1.25 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › MVD-like_N 0.55 44.0 3.79e-01 85.2% 66.8%
6033 212.1.1.15 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › LpxC 0.55 45.0 4.66e-01 91.4% 92.5%
4338606 212.1.1.15 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › LpxC 0.55 45.0 3.49e-01 91.4% 40.4%
4342937 212.1.1.3 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › GHMP_kinases_N 0.54 45.0 4.10e-01 89.1% 71.8%
1202394 212.1.1.25 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › MVD-like_N 0.54 46.0 4.18e-01 93.0% 74.9%
4506923 12.1.1.29 ↗ beta sandwiches › Glycosyl hydrolase domain-like › Glycosyl hydrolase domain › Glycosyl hydrolase domain › Glyco_hydro_30C 0.53 29.0 3.10e-01 72.7% 57.5%
4947770 212.1.1.18 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Lon_C 0.52 45.0 4.57e-01 100.0% 96.2%
5025223 212.1.1.25 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › MVD-like_N 0.52 43.0 3.66e-01 89.1% 60.0%
4028082 212.1.1.10 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › RNase_PH 0.51 42.0 3.98e-01 97.7% 73.5%
D7 medium residues 414-467
PDB
Domain cluster: representative
CATH (20)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1bgwA02 3.40.50.670 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.89 82.0 5.59e-01 100.0% 31.6%
3gr0D01 3.30.70.1780 Alpha Beta › 2-Layer Sandwich › Alpha-Beta Plaits › 0.80 49.0 5.51e-01 72.2% 82.9%
7wgrA03 3.40.50.11610 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain 0.69 53.0 4.09e-01 90.7% 35.9%
6n2nC03 3.40.50.920 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.66 48.0 3.86e-01 90.7% 38.7%
1fj2A00 3.40.50.1820 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain 0.60 47.0 3.20e-01 92.6% 21.4%
1mabA02 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.58 48.0 3.12e-01 100.0% 46.9%
7wgrA02 3.40.50.12470 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.56 47.0 3.09e-01 100.0% 52.5%
3b70A01 3.90.180.10 Alpha Beta › Alpha-Beta Complex › Quinone Oxidoreductase; Chain A, domain 1 › Medium-chain alcohol dehydrogenases, catalytic domain 0.56 44.0 3.24e-01 94.4% 76.6%
5zxnA01 3.90.180.10 Alpha Beta › Alpha-Beta Complex › Quinone Oxidoreductase; Chain A, domain 1 › Medium-chain alcohol dehydrogenases, catalytic domain 0.55 45.0 3.32e-01 94.4% 74.7%
2zbkA02 3.40.1360.10 Alpha Beta › 3-Layer(aba) Sandwich › Dna Topoisomerase Vi A Subunit; Chain: A, domain 2 › 0.55 41.0 2.92e-01 92.6% 34.1%
2j8zA01 3.90.180.10 Alpha Beta › Alpha-Beta Complex › Quinone Oxidoreductase; Chain A, domain 1 › Medium-chain alcohol dehydrogenases, catalytic domain 0.54 43.0 3.09e-01 94.4% 81.7%
5x5jA00 3.40.50.2300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator 0.54 38.0 3.04e-01 75.9% 93.2%
2uzhA00 3.30.1330.50 Alpha Beta › 2-Layer Sandwich › 60s Ribosomal Protein L30; Chain: A; › 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 0.54 38.0 2.87e-01 77.8% 82.4%
2c61A00 3.40.50.12240 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 0.54 46.0 2.77e-01 100.0% 30.9%
2y05A01 3.90.180.10 Alpha Beta › Alpha-Beta Complex › Quinone Oxidoreductase; Chain A, domain 1 › Medium-chain alcohol dehydrogenases, catalytic domain 0.52 42.0 3.11e-01 92.6% 74.7%
4a27A01 3.90.180.10 Alpha Beta › Alpha-Beta Complex › Quinone Oxidoreductase; Chain A, domain 1 › Medium-chain alcohol dehydrogenases, catalytic domain 0.52 41.0 3.08e-01 94.4% 77.2%
3up9A01 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.52 37.0 2.91e-01 81.5% 73.2%
2j3hB01 3.90.180.10 Alpha Beta › Alpha-Beta Complex › Quinone Oxidoreductase; Chain A, domain 1 › Medium-chain alcohol dehydrogenases, catalytic domain 0.51 40.0 2.98e-01 94.4% 73.8%
4f2gA01 3.40.50.1370 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Aspartate/ornithine carbamoyltransferase 0.50 38.0 2.91e-01 87.0% 38.1%
6o9aA02 3.40.190.10 Alpha Beta › 3-Layer(aba) Sandwich › D-Maltodextrin-Binding Protein; domain 2 › Periplasmic binding protein-like II 0.50 39.0 3.25e-01 94.4% 59.3%
ECOD (31)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3213306 2006.1.3.21 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOPRIM_C 0.95 88.0 5.36e-01 98.1% 19.6%
3551383 2006.1.3.3 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim,TOPRIM_C 0.94 88.0 5.33e-01 100.0% 18.6%
4876995 2006.1.3.0 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.93 83.0 6.10e-01 96.3% 45.3%
3789608 2006.1.3.0 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.92 85.0 5.21e-01 98.1% 19.3%
1165402 2006.1.3.3 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim,TOPRIM_C 0.90 83.0 5.92e-01 100.0% 37.5%
1759361 2006.1.3.2 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › Toprim 0.89 82.0 5.86e-01 100.0% 37.8%
3594652 2006.1.3.0 ↗ a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain 0.78 69.0 4.32e-01 98.1% 20.0%
169558 2003.1.5.81 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › S-adenosyl-L-methionine-dependent methyltransferases › Methyltransf_25 0.74 50.0 3.21e-01 70.4% 23.2%
5018445 7522.1.1.0 ↗ a/b three-layered sandwiches › TK C-terminal domain-like › TK C-terminal domain-like › TK C-terminal domain-like 0.65 52.0 3.92e-01 90.7% 36.4%
3697863 2003.1.1.3 ↗ a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › adh_short 0.64 43.0 2.72e-01 70.4% 19.7%
3511052 380.1.1.0 ↗ few secondary structure elements › Kringle-like › Kringle-like › Kringle-like 0.61 41.0 3.08e-01 72.2% 26.0%
3184376 2004.1.1.10 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATP-synt_ab 0.59 51.0 3.73e-01 100.0% 87.1%
None — 0.58 50.0 3.19e-01 100.0% 47.0%
4928484 2005.1.1.13 ↗ a/b three-layered sandwiches › HUP domain-like › HUP domains › HUP domains › CTP_transf_like 0.54 38.0 2.73e-01 75.9% 55.8%
3441196 236.1.1.1 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N 0.54 43.0 3.15e-01 94.4% 76.3%
4929458 236.1.1.1 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N 0.54 43.0 3.00e-01 94.4% 77.5%
5083260 2007.1.16.1 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Iron-sulphur enzyme Dph2 › Diphthamide_syn 0.53 44.0 3.67e-01 98.1% 67.6%
3208338 236.1.1.2 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N,ADH_zinc_N_2 0.53 42.0 3.16e-01 94.4% 77.5%
4162624 236.1.1.1 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N 0.53 43.0 3.09e-01 94.4% 81.6%
4021131 236.1.1.0 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain 0.53 42.0 3.15e-01 94.4% 78.1%
3631333 236.1.1.2 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N,ADH_zinc_N_2 0.53 42.0 3.11e-01 94.4% 75.8%
3476684 236.1.1.1 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N 0.52 43.0 3.15e-01 98.1% 51.8%
3414855 236.1.1.2 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N,ADH_zinc_N_2 0.52 42.0 2.99e-01 94.4% 75.5%
3970638 236.1.1.2 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N,ADH_zinc_N_2 0.52 41.0 3.08e-01 94.4% 79.2%
4889193 2004.1.1.484 ↗ a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › ATP-synt_ab, ATP-synt_ab_C 0.52 41.0 2.69e-01 94.4% 30.9%
3809026 236.1.1.1 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N 0.52 41.0 3.06e-01 94.4% 73.9%
4927856 236.1.1.1 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N 0.51 41.0 2.96e-01 94.4% 81.1%
4532147 7523.1.1.0 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II 0.51 38.0 3.36e-01 88.9% 52.9%
1879147 2007.1.2.4 ↗ a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › Periplasmic binding protein-like I › ANF_receptor 0.51 38.0 3.05e-01 85.2% 50.0%
3273947 236.1.1.2 ↗ beta barrels › GroES-like › GroES-related › Alcohol dehydrogenase-like, N-terminal domain › ADH_N,ADH_zinc_N_2 0.51 40.0 3.04e-01 94.4% 78.1%
4510745 7523.1.1.25 ↗ a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Phosphonate-bd 0.50 39.0 3.27e-01 88.9% 77.0%