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topoisomerase_II

Euk-Vir

African_swine_fever_virus

topoisomerase_II__YP_009702678__African_swine_fever_virus__10497

Identity

Accession:
YP_009702678 ↗
Protein ID:
topoisomerase_II
Kingdom:
euk

Quality

76.2 mean pLDDT

Taxonomy

Bamfordvirae› Nucleocytoviricota› Pokkesviricetes› Asfuvirales› Asfarviridae› Asfivirus› African_swine_fever_virus

TaxID: 10497

Cluster

View cluster (39 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 418-575_614-650
PDB
Domain cluster: rep: DNA_topoisomerase_2__YP_009162467__Salmon_gill_poxvirus__1680908__D385-517_553-621_640-664
D2 high residues 897-1007
PDB
Domain cluster: rep: IMGVR_UViG_3300007985_000017-3300007985-Ga0100381_100027569__D212-299
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF00521.27 best DNA_topoisoIV 36.4 4.10e-09 96.4% 24.4%
D3 high residues 1031-1160
PDB
D4 medium residues 1-57
PDB
D5 medium residues 58-99_191-247
PDB
Domain cluster: representative
CATH (44)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1pvgA01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.86 82.0 5.90e-01 100.0% 74.2%
2o1uB01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.69 63.0 5.28e-01 100.0% 100.0%
1y4uB01 3.30.565.10 Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Histidine kinase-like ATPase, C-terminal domain 0.69 63.0 5.00e-01 100.0% 92.8%
4a18P00 3.30.720.90 Alpha Beta › 2-Layer Sandwich › Signal recognition particle alu RNA binding heterodimer, srp9/1 › 0.64 40.0 4.67e-01 97.0% 95.5%
3agkA02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.62 47.0 4.37e-01 79.8% 76.6%
3cerA02 3.30.420.150 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Exopolyphosphatase. Domain 2 0.62 44.0 3.51e-01 74.7% 87.3%
1okjB01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.62 48.0 4.43e-01 82.8% 92.9%
4af1A02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.62 46.0 4.26e-01 78.8% 82.5%
5i9eA02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.61 34.0 3.25e-01 96.0% 45.5%
3obwA02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.61 46.0 4.36e-01 79.8% 74.6%
6f95A01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.60 45.0 3.93e-01 78.8% 98.0%
3wxmB02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.60 45.0 4.20e-01 79.8% 72.1%
4ac9C01 3.40.50.300 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases 0.59 42.0 3.45e-01 97.0% 40.4%
1sazA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.59 44.0 3.65e-01 79.8% 65.9%
2a6aB01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.58 45.0 4.21e-01 80.8% 95.8%
3mdqA02 3.30.420.150 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Exopolyphosphatase. Domain 2 0.58 42.0 3.42e-01 76.8% 88.4%
3hi0A01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.57 46.0 4.37e-01 86.9% 92.3%
3i8bA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.57 43.0 3.14e-01 80.8% 98.2%
1t6cA02 3.30.420.150 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Exopolyphosphatase. Domain 2 0.56 41.0 3.36e-01 75.8% 88.4%
1fr3A00 2.40.50.100 Mainly Beta › Beta Barrel › OB fold (Dihydrolipoamide Acetyltransferase, E2P) › RNA polymerase II/Efflux pump adaptor protein, barrel-sandwich hybrid domain 0.56 28.0 3.31e-01 82.8% 67.2%
1t6cA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.56 43.0 3.99e-01 81.8% 83.2%
3mdqA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.56 41.0 3.90e-01 79.8% 82.9%
1dt9A02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.55 42.0 4.02e-01 79.8% 74.1%
3h6eB01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.55 42.0 4.24e-01 85.9% 81.8%
4ijaB02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.54 41.0 3.56e-01 80.8% 65.0%
3wt0A02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.54 40.0 3.49e-01 78.8% 94.4%
7r8iA01 3.30.420.10 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H 0.54 40.0 3.19e-01 80.8% 81.1%
2qm1B01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.53 41.0 3.61e-01 83.8% 71.7%
2ychA03 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.53 40.0 3.82e-01 80.8% 95.0%
5aj3K00 3.30.420.80 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribosomal protein S11/S14 0.53 39.0 3.53e-01 76.8% 68.4%
2fsjA02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.53 40.0 3.61e-01 80.8% 95.7%
1hkgA02 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.53 39.0 3.60e-01 78.8% 93.8%
3obyA02 3.30.420.60 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › eRF1 domain 2 0.53 38.0 3.75e-01 78.8% 69.7%
4c23B01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.52 44.0 3.44e-01 96.0% 79.1%
3hi0A02 3.30.420.150 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Exopolyphosphatase. Domain 2 0.52 37.0 3.10e-01 75.8% 83.6%
2xzmK00 3.30.420.80 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribosomal protein S11/S14 0.51 41.0 3.74e-01 88.9% 78.6%
1woqA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.51 38.0 3.74e-01 80.8% 95.5%
6mlyB01 2.115.10.20 Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43 0.51 42.0 3.22e-01 96.0% 93.9%
4hkqA04 3.10.20.370 Alpha Beta › Roll › Ubiquitin-like (UB roll) › 0.50 37.0 4.04e-01 79.8% 100.0%
3b34A01 2.60.40.1730 Mainly Beta › Sandwich › Immunoglobulin-like › tricorn interacting facor f3 domain 0.50 40.0 3.37e-01 87.9% 91.7%
1fx5B00 2.60.120.200 Mainly Beta › Sandwich › Jelly Rolls › 0.50 43.0 3.31e-01 96.0% 47.7%
3bexA01 3.30.420.40 Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › ATPase, nucleotide binding domain 0.50 37.0 3.40e-01 78.8% 98.5%
3qeeB00 2.115.10.20 Mainly Beta › 5 Propeller › Tachylectin-2; Chain A › Glycosyl hydrolase domain; family 43 0.50 42.0 3.11e-01 97.0% 87.0%
1ms9A01 2.120.10.10 Mainly Beta › 6 Propeller › Neuraminidase › 0.50 41.0 2.90e-01 93.9% 89.7%
ECOD (70)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4875911 225.1.1.3 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c 0.97 94.0 6.60e-01 100.0% 72.8%
5004468 225.1.1.19 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › SACS 0.72 64.0 5.09e-01 99.0% 83.5%
4969896 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.71 65.0 5.05e-01 100.0% 87.1%
3825487 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.69 64.0 4.72e-01 100.0% 89.1%
3286344 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.68 60.0 4.59e-01 97.0% 82.7%
5000498 896.1.1.1 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Ribosomal_L38e 0.67 40.0 4.83e-01 90.9% 96.7%
2814146 896.1.1.1 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Ribosomal_L38e 0.67 44.0 4.86e-01 94.9% 86.8%
4221311 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.67 61.0 4.67e-01 100.0% 80.5%
3367679 225.1.1.13 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HSP90 0.66 59.0 4.87e-01 97.0% 100.0%
5074128 896.1.1.0 ↗ a+b two layers › SRP9/14-like › Signal recognition particle alu RNA binding heterodimer SRP9/14-related › Signal recognition particle alu RNA binding heterodimer SRP9/14-related 0.66 40.0 4.68e-01 96.0% 92.3%
3721928 225.1.1.0 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase 0.66 59.0 4.56e-01 99.0% 79.5%
5027973 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.65 60.0 4.64e-01 99.0% 85.4%
5057421 225.1.1.7 ↗ a+b two layers › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase-like › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase › HATPase_c_3 0.63 58.0 4.50e-01 100.0% 85.2%
4977337 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.63 48.0 4.24e-01 81.8% 72.0%
1731428 2484.1.1.10 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › TsaD 0.61 45.0 4.45e-01 76.8% 87.7%
140445 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.61 46.0 4.32e-01 79.8% 72.7%
5024122 2484.1.1.53 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › MreB_Mbl 0.61 46.0 3.91e-01 80.8% 77.1%
3237906 2484.1.1.200 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › FTH 0.61 49.0 3.51e-01 86.9% 47.8%
3242105 207.1.1.81 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › FTH 0.61 45.0 3.61e-01 78.8% 56.0%
4190296 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.61 46.0 4.31e-01 79.8% 75.0%
3952658 2484.1.1.113 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › baeRF_family2 0.60 45.0 4.21e-01 79.8% 81.6%
4246561 2484.1.1.10 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › TsaD 0.60 46.0 4.43e-01 78.8% 88.2%
4497431 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.60 45.0 4.18e-01 79.8% 76.8%
4991620 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.60 45.0 4.33e-01 80.8% 79.1%
4983075 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.60 45.0 4.17e-01 79.8% 74.4%
3726158 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.59 43.0 3.63e-01 77.8% 93.3%
4378051 2484.1.1.10 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › TsaD 0.59 46.0 4.32e-01 81.8% 96.7%
4932883 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.59 44.0 4.09e-01 78.8% 75.2%
3690393 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.59 44.0 3.91e-01 80.8% 82.7%
1157718 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.59 47.0 4.29e-01 85.9% 73.1%
5031007 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.58 44.0 4.13e-01 80.8% 76.0%
5052862 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.58 46.0 4.45e-01 85.9% 87.0%
3189096 2484.1.1.7 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Ribosomal_S11 0.58 44.0 4.04e-01 79.8% 76.9%
3514660 330.1.1.1 ↗ a+b two layers › dsRBD-like › dsRNA-binding domain-like › dsRNA-binding domain-like › dsrm 0.58 33.0 3.44e-01 73.7% 58.9%
3233889 207.1.1.81 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › FTH 0.58 47.0 3.45e-01 87.9% 45.3%
3585719 2484.1.1.1 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › HSP70 0.58 45.0 3.58e-01 83.8% 86.3%
3595891 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.57 43.0 3.46e-01 78.8% 85.1%
4936812 2484.1.1.49 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Hydant_A_N 0.57 38.0 3.59e-01 99.0% 54.4%
3658182 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.57 43.0 3.64e-01 79.8% 98.8%
5057683 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.56 44.0 4.11e-01 83.8% 77.6%
4962202 2484.1.1.49 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Hydant_A_N 0.56 42.0 3.79e-01 100.0% 57.0%
5036730 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.56 42.0 4.01e-01 80.8% 75.0%
4255201 2484.1.1.7 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Ribosomal_S11 0.56 40.0 3.94e-01 75.8% 81.8%
4376375 2484.1.1.49 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Hydant_A_N 0.56 44.0 3.93e-01 100.0% 58.6%
4972398 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.56 45.0 3.93e-01 89.9% 71.2%
5072189 2484.1.1.6 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › FGGY_N 0.56 41.0 3.66e-01 79.8% 76.1%
4159425 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.56 42.0 3.98e-01 79.8% 72.5%
3741985 2484.1.1.7 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Ribosomal_S11 0.56 41.0 3.86e-01 78.8% 77.6%
5002665 2484.1.1.29 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Ppx-GppA 0.56 41.0 3.44e-01 77.8% 83.4%
1238974 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.56 43.0 3.99e-01 84.8% 73.8%
3990809 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.55 45.0 4.51e-01 88.9% 98.0%
3241311 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.55 46.0 3.77e-01 92.9% 68.4%
3588565 6048.1.1.1 ↗ a+b two layers › DUF960-like › DUF960-like › DUF960-like › DUF960 0.55 42.0 4.42e-01 100.0% 92.0%
4982365 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.54 42.0 3.92e-01 82.8% 72.0%
4939492 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.54 42.0 3.89e-01 82.8% 73.6%
5035283 2484.1.1.38 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › eRF1_2 0.54 40.0 3.77e-01 79.8% 76.0%
3243569 207.1.1.81 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › FTH 0.54 44.0 3.43e-01 90.9% 59.1%
5022045 11.1.1.0 ↗ beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like 0.54 44.0 4.13e-01 87.9% 89.2%
3630575 207.1.1.0 ↗ beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats 0.53 40.0 2.96e-01 79.8% 43.0%
4068244 2484.1.1.49 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Hydant_A_N 0.53 40.0 3.53e-01 99.0% 53.3%
4969281 4263.1.1.0 ↗ a+b two layers › TTHA1528-like › TTHA1528-like › TTHA1528-like 0.53 46.0 4.21e-01 100.0% 83.7%
3490628 2484.1.1.7 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Ribosomal_S11 0.53 38.0 3.57e-01 77.8% 72.9%
4388645 2484.1.1.7 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Ribosomal_S11 0.52 42.0 3.94e-01 87.9% 75.8%
4080507 2484.1.1.37 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Pan_kinase 0.52 37.0 3.58e-01 74.7% 70.4%
4140416 2484.1.1.31 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Glucokinase 0.52 39.0 3.58e-01 79.8% 94.6%
5071337 2484.1.1.49 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Hydant_A_N 0.52 38.0 3.77e-01 78.8% 92.4%
3252808 1170.1.2.0 ↗ beta barrels › IL8-related › IL8-related › chemokine-related domain in glycoprotein L (gL) 0.52 33.0 3.78e-01 89.9% 91.4%
3783436 3270.1.1.1 ↗ a+b two layers › a+b domain in heme oxygenase › a+b domain in heme oxygenase › a+b domain in heme oxygenase › DUF2470 0.51 40.0 4.02e-01 99.0% 81.9%
3239485 2484.1.1.0 ↗ mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like 0.51 45.0 4.15e-01 100.0% 96.2%
4963351 220.1.1.0 ↗ beta barrels › PH domain-like › PH domain-like › PH domain-like 0.51 42.0 3.94e-01 90.9% 74.2%
D6 medium residues 100-190
PDB
Domain cluster: rep: GyrB-like_ATPase_domain_protein__YP_784274__Nile_crocodilepox_virus__1285600__D74-178
D7 medium residues 248-413
PDB
Domain cluster: rep: topoisomerase_IIA__YP_009001040__Pithovirus_sibericum__1450746__D250-321_335-390
CATH (11)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1qzrA02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.87 63.0 7.30e-01 84.3% 100.0%
3zkbI02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.78 71.0 7.29e-01 99.4% 100.0%
3lnuA02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.76 70.0 7.12e-01 98.2% 100.0%
3cwvA02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.76 65.0 6.84e-01 98.2% 100.0%
4hy1A02 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.75 68.0 6.95e-01 99.4% 100.0%
1z5bB03 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.69 58.0 6.10e-01 95.8% 99.3%
1xhkA00 3.30.230.10 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › 0.61 40.0 3.93e-01 78.3% 58.9%
1ffvB04 3.30.365.10 Alpha Beta › 2-Layer Sandwich › Aldehyde Oxidoreductase; domain 4 › Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain 0.55 48.0 4.59e-01 95.2% 94.9%
1vi7A01 3.30.230.30 Alpha Beta › 2-Layer Sandwich › Ribosomal Protein S5; domain 2 › Impact, N-terminal domain 0.54 40.0 4.45e-01 83.7% 94.8%
3oc4B03 3.30.390.30 Alpha Beta › 2-Layer Sandwich › Enolase-like; domain 1 › FAD/NAD-linked reductase, C-terminal dimerisation domain 0.51 33.0 3.70e-01 85.5% 86.0%
3cm1A00 2.30.31.20 Mainly Beta › Roll › Transcriptional Co-activator pc4; Chain A › Sporulation-specific cell division protein SsgB 0.50 37.0 4.07e-01 91.0% 93.4%
ECOD (47)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3433616 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.84 75.0 7.68e-01 96.4% 96.9%
4000834 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.84 77.0 7.79e-01 98.2% 97.0%
3585145 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.83 75.0 7.66e-01 95.8% 97.5%
3799215 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.83 75.0 7.59e-01 98.2% 95.8%
3513708 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.82 75.0 7.65e-01 97.0% 98.8%
3275256 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.82 76.0 7.58e-01 97.0% 97.1%
4261801 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.81 76.0 7.25e-01 99.4% 91.6%
4234522 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.81 75.0 7.44e-01 97.6% 97.1%
3807571 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.80 75.0 7.42e-01 98.8% 94.9%
4641709 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.80 75.0 7.27e-01 97.6% 95.0%
1388837 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.80 67.0 7.18e-01 94.6% 100.0%
4027043 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.80 74.0 7.33e-01 98.2% 96.0%
3970715 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.79 74.0 7.33e-01 99.4% 96.0%
3964340 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.79 75.0 7.18e-01 100.0% 94.6%
4380841 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.79 74.0 7.28e-01 98.8% 94.9%
4298571 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.79 74.0 7.10e-01 99.4% 94.1%
4945732 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.78 73.0 7.16e-01 98.2% 95.4%
3594648 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.77 68.0 6.92e-01 95.8% 95.0%
3220683 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.77 72.0 7.28e-01 98.2% 100.0%
4040519 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.77 67.0 6.77e-01 95.8% 92.1%
4288775 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.77 71.0 6.96e-01 99.4% 95.0%
3967155 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.77 72.0 7.05e-01 99.4% 95.4%
4339883 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.76 71.0 6.80e-01 98.8% 95.7%
4207771 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.76 71.0 6.97e-01 99.4% 95.4%
341211 212.1.1.2 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › DNA_gyraseB 0.75 65.0 6.80e-01 97.6% 100.0%
4938668 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.71 44.0 5.44e-01 78.9% 97.1%
5033236 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.70 61.0 4.83e-01 93.4% 47.0%
3318637 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.69 58.0 5.84e-01 93.4% 89.1%
3823703 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.69 58.0 5.06e-01 93.4% 61.3%
5044782 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.68 57.0 5.44e-01 93.4% 76.8%
5031188 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.68 44.0 4.57e-01 80.1% 69.0%
4584919 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.68 59.0 5.51e-01 93.4% 76.0%
3670258 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.68 57.0 5.81e-01 95.2% 93.1%
4661396 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.67 57.0 5.18e-01 95.8% 67.1%
4928705 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.67 58.0 5.38e-01 93.4% 75.2%
5037280 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.67 60.0 5.55e-01 95.8% 79.0%
4028943 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.67 59.0 5.36e-01 94.6% 74.1%
4941612 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.67 58.0 5.19e-01 95.2% 67.4%
4957148 212.1.1.22 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Topo-VIb_trans 0.65 56.0 5.24e-01 93.4% 76.0%
3590260 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.64 40.0 4.71e-01 77.7% 88.7%
3170502 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.64 49.0 5.39e-01 82.5% 100.0%
3991620 212.1.1.25 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › MVD-like_N 0.58 45.0 4.18e-01 79.5% 75.6%
5015926 212.1.1.0 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like 0.57 41.0 4.49e-01 89.2% 89.3%
4983864 244.2.1.1 ↗ a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD/NAD-linked reduatases, dimerisation (C-terminal) domain › FAD/NAD-linked reduatases, dimerisation (C-terminal) domain › Pyr_redox_dim 0.54 34.0 3.85e-01 83.7% 83.3%
5001433 244.2.1.1 ↗ a+b two layers › FAD-linked reductases, C-terminal domain-like › FAD/NAD-linked reduatases, dimerisation (C-terminal) domain › FAD/NAD-linked reduatases, dimerisation (C-terminal) domain › Pyr_redox_dim 0.53 35.0 3.83e-01 86.1% 80.7%
4126991 243.3.1.0 ↗ a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin 0.52 24.0 3.19e-01 75.3% 78.9%
3710045 212.1.1.10 ↗ a+b two layers › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › Ribosomal protein S5 domain 2-like › RNase_PH 0.51 40.0 3.96e-01 93.4% 76.1%
D8 medium residues 651-729
PDB
Domain cluster: rep: DNA_topoisomerase_2__YP_007353996__Acanthamoeba_polyphaga_moumouvirus__1269028__D17-77
CATH (4)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
3wd6A02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.57 37.0 3.32e-01 72.2% 44.9%
1xeqB00 1.10.287.10 Mainly Alpha › Orthogonal Bundle › Helix Hairpins › S15/NS1, RNA-binding 0.55 37.0 3.62e-01 70.9% 63.5%
2yf4F00 1.10.3420.10 Mainly Alpha › Orthogonal Bundle › putative ntp pyrophosphohydrolase like fold › putative ntp pyrophosphohydrolase like domain 0.53 38.0 3.28e-01 78.5% 66.4%
3ppuB02 1.20.1050.10 Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › 0.51 36.0 3.28e-01 74.7% 85.0%
ECOD (2)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3998759 109.4.1.1251 ↗ alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › TPR_XPO7 0.54 44.0 2.54e-01 93.7% 20.0%
3760982 150.3.1.1 ↗ alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › Hormone_1 0.51 43.0 3.34e-01 93.7% 79.4%