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transactivating_tegument_protein_VP16

Euk-Vir

Macacine_alphaherpesvirus_1

transactivating_tegument_protein_VP16__NP_851908__Macacine_alphaherpesvirus_1__10325

Identity

Accession:: NP_851908 ↗
Protein ID:: transactivating_tegument_protein_VP16
Kingdom:: euk

Quality

73.9 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Macacine_alphaherpesvirus_1

TaxID: 10325

Cluster

View cluster (32 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 89-249_326-361

PDB

Domain cluster: rep: transactivating_tegument_protein_VP16__YP_002333493__Equid_alphaherpesvirus_9__55744__D57-147_162-249_335-395

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02232.20 best	Alpha_TIF	233.3	6.10e-69	83.2%	47.2%

CATH (9)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
16vpA00	1.10.1290.10	Mainly Alpha › Orthogonal Bundle › Conserved core of transcriptional regulatory protein vp16 › Alpha trans-inducing (Alpha-TIF)	0.99	92.0	7.56e-01	94.4%	84.2%
2w2dD01	1.20.1120.10	Mainly Alpha › Up-down Bundle › "Clostridium botulinum neurotoxin B, ""coiled-coil"" domain" › "Clostridium botulinum neurotoxin b, ""coiled-coil"" domain"	0.73	55.0	4.25e-01	76.6%	95.3%
4q4hA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.57	41.0	3.54e-01	73.6%	89.9%
6v9zA02	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.55	40.0	3.36e-01	72.1%	85.5%
6tqfA01	1.20.1560.10	Mainly Alpha › Up-down Bundle › ABC transporter transmembrane region fold › ABC transporter type 1, transmembrane domain	0.54	38.0	3.01e-01	70.1%	80.3%
1fgjA02	1.20.850.10	Mainly Alpha › Up-down Bundle › Hydroxylamine Oxidoreductase; Chain A, domain 2 › Hydroxylamine Oxidoreductase; Chain A, domain 2	0.53	37.0	3.56e-01	71.1%	80.0%
3ezhA00	1.20.120.960	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Histidine kinase NarX, sensor domain	0.52	30.0	3.88e-01	74.6%	98.2%
4rfsS00	1.10.1760.20	Mainly Alpha › Orthogonal Bundle › Arp2/3 complex 21 kDa subunit ARPC3 ›	0.51	39.0	3.99e-01	95.9%	81.8%
3t6gB00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.51	32.0	3.73e-01	76.6%	90.3%

ECOD (9)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
7584	816.1.1.1 ↗	a+b complex topology › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Alpha_TIF	0.99	92.0	7.63e-01	94.4%	86.5%
5051910	1075.3.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1	0.58	49.0	4.02e-01	89.8%	60.3%
3414672	4177.1.1.0 ↗	alpha duplicates or obligate multimers › BAR/IMD domain-like › BAR/IMD domain-like › BAR/IMD domain-like	0.57	40.0	4.09e-01	70.6%	91.6%
4160480	3615.1.1.0 ↗	alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain	0.56	44.0	4.20e-01	86.3%	67.7%
4971425	1075.3.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1	0.55	48.0	4.41e-01	93.9%	89.4%
4363167	1075.3.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold › BPD_transp_1	0.53	46.0	4.54e-01	91.9%	95.7%
3601022	5076.1.1.0 ↗	alpha complex topology › Mitochondrial ADP/ATP carrier-like › Mitochondrial ADP/ATP carrier › Mitochondrial ADP/ATP carrier	0.52	47.0	4.12e-01	99.0%	86.7%
3172946	601.19.1.40 ↗	alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › PF28954	0.52	36.0	3.80e-01	70.1%	77.2%
3859555	601.19.1.1 ↗	alpha bundles › Four-helical up-and-down bundle › Apolipoprotein › Apolipoprotein › Apolipoprotein	0.51	40.0	4.21e-01	83.2%	92.2%

D2 medium residues 250-325

PDB

Domain cluster: rep: transactivating_tegument_protein_VP16__YP_009042110__Fruit_bat_alphaherpesvirus_1__1343901__D263-283_301-318_392-407

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF02232.20 best	Alpha_TIF	99.7	2.70e-28	100.0%	21.9%