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transactivating_tegument_protein_VP16
Euk-VirMacropodid_alphaherpesvirus_1
transactivating_tegument_protein_VP16__YP_009227280__Macropodid_alphaherpesvirus_1__137443
Identity
- Accession:
- YP_009227280 ↗
- Protein ID:
- transactivating_tegument_protein_VP16
- Kingdom:
- euk
Quality
70.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Macropodid_alphaherpesvirus_1
TaxID: 137443
Cluster
View cluster (32 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 26-151
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 152.6 | 2.10e-44 | 100.0% | 35.9% |
CATH (2)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 16vpA00 | 1.10.1290.10 | Mainly Alpha › Orthogonal Bundle › Conserved core of transcriptional regulatory protein vp16 › Alpha trans-inducing (Alpha-TIF) | 0.97 | 92.0 | 6.57e-01 | 97.6% | 39.5% |
| 1m62A00 | 1.20.58.120 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › BAG domain | 0.52 | 27.0 | 3.18e-01 | 100.0% | 71.3% |
ECOD (1)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7584 | 816.1.1.1 ↗ | a+b complex topology › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Alpha_TIF | 0.97 | 92.0 | 6.62e-01 | 97.6% | 40.6% |
D2
medium
residues 152-231
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 75.1 | 7.80e-21 | 100.0% | 23.0% |
CATH (18)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 16vpA00 | 1.10.1290.10 | Mainly Alpha › Orthogonal Bundle › Conserved core of transcriptional regulatory protein vp16 › Alpha trans-inducing (Alpha-TIF) | 0.96 | 92.0 | 5.89e-01 | 100.0% | 25.7% |
| 1s7bA00 | 1.10.3730.20 | Mainly Alpha › Orthogonal Bundle › ProC C-terminal domain-like fold › | 0.77 | 47.0 | 4.32e-01 | 75.0% | 47.2% |
| 1gakA00 | 1.20.150.10 | Mainly Alpha › Up-down Bundle › Lysin › Fertilization protein | 0.70 | 52.0 | 4.36e-01 | 78.8% | 48.2% |
| 1iipA02 | 1.10.150.160 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.69 | 52.0 | 5.12e-01 | 100.0% | 76.5% |
| 3favD00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.69 | 53.0 | 5.36e-01 | 85.0% | 84.6% |
| 2bnlC00 | 1.10.490.10 | Mainly Alpha › Orthogonal Bundle › Globin-like › Globins | 0.68 | 47.0 | 4.02e-01 | 73.8% | 43.3% |
| 1knzA01 | 6.10.280.20 | Special › Helix non-globular › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Rotavirus non-structural protein NSP3, N-terminal domain | 0.67 | 52.0 | 4.84e-01 | 85.0% | 70.6% |
| 1aj3A00 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.66 | 50.0 | 4.66e-01 | 87.5% | 65.3% |
| 2ahmG01 | 6.10.250.2820 | Special › Helix non-globular › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › | 0.65 | 57.0 | 5.29e-01 | 96.2% | 80.8% |
| 1x04A00 | 1.20.1270.60 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Arfaptin homology (AH) domain/BAR domain | 0.64 | 56.0 | 4.24e-01 | 100.0% | 82.5% |
| 2oduA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 42.0 | 3.89e-01 | 93.8% | 52.4% |
| 3fb2A01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.63 | 42.0 | 3.87e-01 | 95.0% | 52.4% |
| 1ks9A02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.63 | 41.0 | 3.53e-01 | 72.5% | 43.1% |
| 5hyhA00 | 1.10.620.20 | Mainly Alpha › Orthogonal Bundle › Ribonucleotide Reductase, subunit A › Ribonucleotide Reductase, subunit A | 0.60 | 43.0 | 2.97e-01 | 75.0% | 22.0% |
| 2odvA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 43.0 | 3.90e-01 | 90.0% | 57.1% |
| 2h92A00 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.56 | 40.0 | 2.97e-01 | 76.2% | 47.7% |
| 2lw1A00 | 1.10.287.380 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Valyl-tRNA synthetase, C-terminal domain | 0.53 | 39.0 | 3.85e-01 | 86.3% | 72.9% |
| 3kv0A01 | 1.10.3520.10 | Mainly Alpha › Orthogonal Bundle › Glycolipid transfer protein, GLTP › Glycolipid transfer protein | 0.52 | 43.0 | 3.35e-01 | 90.0% | 54.7% |
ECOD (31)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7584 | 816.1.1.1 ↗ | a+b complex topology › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Alpha_TIF | 0.96 | 92.0 | 5.92e-01 | 100.0% | 26.4% |
| 4959229 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.82 | 62.0 | 4.60e-01 | 98.8% | 33.7% |
| 4242465 | 547.1.1.1 ↗ | alpha duplicates or obligate multimers › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › Glutamyl tRNA-reductase dimerization domain › GlutR_dimer | 0.80 | 62.0 | 5.84e-01 | 82.5% | 68.4% |
| 3725506 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.76 | 54.0 | 4.83e-01 | 100.0% | 53.6% |
| 3970666 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.74 | 61.0 | 6.26e-01 | 91.3% | 96.0% |
| 3991853 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.73 | 54.0 | 4.97e-01 | 80.0% | 60.0% |
| 3512559 | 192.1.1.37 ↗ | alpha bundles › Long alpha-hairpin › GreA transcript cleavage protein, N-terminal domain › GreA transcript cleavage protein, N-terminal domain › DUF7753 | 0.73 | 53.0 | 5.80e-01 | 77.5% | 95.4% |
| 3940867 | 632.22.1.67 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › DUF842 | 0.72 | 54.0 | 5.13e-01 | 81.2% | 71.6% |
| 3703706 | 2485.1.1.0 ↗ | a+b three layers › Thioredoxin-like › Thioredoxin-like › Thioredoxin-like | 0.72 | 64.0 | 4.77e-01 | 100.0% | 42.0% |
| 3712816 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.70 | 62.0 | 4.96e-01 | 100.0% | 61.3% |
| 4123269 | 3291.1.1.0 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related | 0.69 | 61.0 | 5.58e-01 | 98.8% | 74.3% |
| 4968578 | 210.1.2.0 ↗ | a+b four layers › Ntn/PP2C › Ntn › Penicillin acylase, catalytic domain | 0.68 | 52.0 | 3.35e-01 | 85.0% | 17.1% |
| 4975050 | 3843.1.1.0 ↗ | alpha complex topology › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K › NADH-quinone oxidoreductase subunit K | 0.68 | 40.0 | 4.16e-01 | 80.0% | 62.7% |
| 3945729 | 604.32.1.0 ↗ | alpha bundles › Spectrin repeat-like › Recombination protein uvsY › Recombination protein uvsY | 0.67 | 56.0 | 4.83e-01 | 93.8% | 68.5% |
| 3608012 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.67 | 46.0 | 4.53e-01 | 88.7% | 67.1% |
| 3596490 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.67 | 43.0 | 4.18e-01 | 91.3% | 58.9% |
| 4237257 | 632.15.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Staphylococcal complement inhibitor (SCIN) › Staphylococcal complement inhibitor (SCIN) | 0.67 | 46.0 | 4.46e-01 | 71.2% | 64.4% |
| 4939465 | 622.1.1.0 ↗ | alpha bundles › YvfG-like › HSC20 (HSCB), C-terminal oligomerisation domain › HSC20 (HSCB), C-terminal oligomerisation domain | 0.65 | 46.0 | 4.14e-01 | 75.0% | 52.2% |
| 4018473 | 5043.2.1.0 ↗ | extended segments › Sensor proteins transmembrane domains › NarQ transmembrane domain › NarQ transmembrane domain | 0.65 | 46.0 | 3.83e-01 | 76.2% | 40.7% |
| 3999274 | 5086.1.1.102 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › PTHB1_hp | 0.64 | 45.0 | 4.11e-01 | 97.5% | 55.2% |
| 2142296 | 150.1.1.3 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › Rubrerythrin | 0.63 | 40.0 | 3.76e-01 | 87.5% | 52.0% |
| 4024699 | 3871.1.1.1 ↗ | alpha duplicates or obligate multimers › PHIST › PHIST › PHIST › PRESAN | 0.63 | 52.0 | 4.28e-01 | 91.3% | 50.3% |
| 3994728 | 7094.1.1.3 ↗ | alpha bundles › Paddle domain of mitochondrial dynamin › Paddle domain of mitochondrial dynamin › Paddle domain of mitochondrial dynamin › OPA1_C | 0.62 | 44.0 | 3.68e-01 | 77.5% | 42.9% |
| 3474929 | 3911.1.1.1 ↗ | extended segments › Exosome complex protein LRP1 › Exosome complex protein LRP1 › Exosome complex protein LRP1 › Sas10_Utp3 | 0.61 | 45.0 | 4.05e-01 | 83.7% | 54.2% |
| 3972084 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.60 | 51.0 | 4.48e-01 | 98.8% | 61.6% |
| 4408604 | 150.5.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › ESAT-6 like › ESAT-6 like | 0.60 | 53.0 | 3.73e-01 | 98.8% | 49.6% |
| 3855780 | 604.1.1.66 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_1st_PEPL | 0.59 | 40.0 | 3.62e-01 | 85.0% | 49.6% |
| 3907844 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.59 | 46.0 | 3.57e-01 | 87.5% | 37.4% |
| 3628140 | 3826.1.1.43 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Med14 | 0.58 | 47.0 | 4.27e-01 | 90.0% | 66.4% |
| 3482273 | 604.7.1.1 ↗ | alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › TBCA | 0.58 | 45.0 | 4.09e-01 | 92.5% | 62.4% |
| 3892492 | 604.1.1.66 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat › Spectrin_1st_PEPL | 0.54 | 40.0 | 3.65e-01 | 85.0% | 57.3% |