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transactivating_tegument_protein_VP16
Euk-VirCanid_alphaherpesvirus_1
transactivating_tegument_protein_VP16__YP_009252238__Canid_alphaherpesvirus_1__170325
Identity
- Accession:
- YP_009252238 ↗
- Protein ID:
- transactivating_tegument_protein_VP16
- Kingdom:
- euk
Quality
77.2
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Canid_alphaherpesvirus_1
TaxID: 170325
Cluster
View cluster (32 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 24-228_290-371
Domain cluster:
rep: transactivating_tegument_protein_VP16__YP_002333493__Equid_alphaherpesvirus_9__55744__D57-147_162-249_335-395
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 205.6 | 1.70e-60 | 72.1% | 60.1% |
| PF02232.20 | Alpha_TIF | 64.2 | 1.70e-17 | 25.1% | 20.4% |
D2
medium
residues 230-289
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 73.4 | 2.60e-20 | 100.0% | 17.2% |
CATH (15)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 16vpA00 | 1.10.1290.10 | Mainly Alpha › Orthogonal Bundle › Conserved core of transcriptional regulatory protein vp16 › Alpha trans-inducing (Alpha-TIF) | 0.94 | 88.0 | 5.38e-01 | 100.0% | 19.3% |
| 2j5bB01 | 3.40.50.620 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › HUPs | 0.61 | 51.0 | 3.62e-01 | 95.0% | 81.2% |
| 1tkkA02 | 3.20.20.120 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain | 0.61 | 51.0 | 3.47e-01 | 98.3% | 41.0% |
| 2zadA02 | 3.20.20.120 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain | 0.59 | 50.0 | 3.46e-01 | 100.0% | 54.3% |
| 3ce7A00 | 1.10.1200.10 | Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › ACP-like | 0.59 | 43.0 | 3.77e-01 | 78.3% | 63.3% |
| 2qlcA00 | 3.40.140.10 | Alpha Beta › 3-Layer(aba) Sandwich › Cytidine Deaminase; domain 2 › Cytidine Deaminase, domain 2 | 0.58 | 50.0 | 4.03e-01 | 100.0% | 87.3% |
| 3jvdA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 51.0 | 3.97e-01 | 100.0% | 76.5% |
| 3k9cA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 50.0 | 3.86e-01 | 100.0% | 78.0% |
| 2kj5A00 | 1.10.150.130 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Tyrosine recombinase, N-terminal domain | 0.56 | 45.0 | 3.75e-01 | 93.3% | 80.2% |
| 1sjyA00 | 3.90.79.10 | Alpha Beta › Alpha-Beta Complex › Nucleoside Triphosphate Pyrophosphohydrolase › Nucleoside Triphosphate Pyrophosphohydrolase | 0.55 | 42.0 | 3.19e-01 | 85.0% | 82.5% |
| 2xrhA00 | 1.20.120.1430 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HP0721 helical bundle | 0.54 | 43.0 | 3.77e-01 | 93.3% | 78.0% |
| 2ofiA00 | 1.10.340.30 | Mainly Alpha › Orthogonal Bundle › Endonuclease III; domain 1 › Hypothetical protein; domain 2 | 0.53 | 44.0 | 3.18e-01 | 95.0% | 83.1% |
| 2ixaA01 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.53 | 45.0 | 3.35e-01 | 100.0% | 57.4% |
| 3oeeY02 | 3.40.1380.10 | Alpha Beta › 3-Layer(aba) Sandwich › Pyruvate Kinase; Chain: A, domain 1 › ATP synthase, F1 complex, gamma subunit | 0.51 | 42.0 | 3.27e-01 | 93.3% | 81.6% |
| 4q0mA01 | 3.40.50.1170 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › L-asparaginase, N-terminal domain | 0.50 | 41.0 | 3.00e-01 | 100.0% | 81.9% |
ECOD (11)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7584 | 816.1.1.1 ↗ | a+b complex topology › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Alpha_TIF | 0.94 | 88.0 | 5.40e-01 | 100.0% | 19.8% |
| 3889259 | 207.1.1.28 ↗ | beta duplicates or obligate multimers › Single-stranded right-handed beta-helix › Leucine-rich repeats › Leucine-rich repeats › LRR_9 | 0.60 | 47.0 | 3.60e-01 | 93.3% | 36.0% |
| 4962245 | 2002.1.1.174 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › MR_MLE_C | 0.59 | 50.0 | 3.48e-01 | 100.0% | 55.6% |
| 4421220 | 2495.1.1.0 ↗ | a/b three-layered sandwiches › Cell-division inhibitor MinC, N-terminal domain › Cell-division inhibitor MinC, N-terminal domain › Cell-division inhibitor MinC, N-terminal domain | 0.57 | 47.0 | 4.15e-01 | 96.7% | 73.7% |
| 4449644 | 2003.1.1.22 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › NAD(P)-binding Rossmann-fold domains › GFO_IDH_MocA | 0.57 | 47.0 | 3.33e-01 | 96.7% | 48.1% |
| 3722224 | 2007.1.3.0 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › CheY-like | 0.57 | 47.0 | 3.77e-01 | 91.7% | 78.0% |
| 5022729 | 247.1.1.1 ↗ | a+b four layers › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase › Metallo-hydrolase/oxidoreductase › Lactamase_B | 0.56 | 47.0 | 3.32e-01 | 100.0% | 89.8% |
| 4576888 | 2495.1.1.1 ↗ | a/b three-layered sandwiches › Cell-division inhibitor MinC, N-terminal domain › Cell-division inhibitor MinC, N-terminal domain › Cell-division inhibitor MinC, N-terminal domain › MinC_N | 0.55 | 44.0 | 4.04e-01 | 98.3% | 82.2% |
| 4929796 | 2006.1.3.11 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › Toprim domain › TOP6A-Spo11_Toprim | 0.54 | 44.0 | 3.32e-01 | 100.0% | 73.6% |
| None | — | 0.54 | 43.0 | 3.28e-01 | 93.3% | 60.6% | |
| 5036933 | 7574.1.1.5 ↗ | a/b three-layered sandwiches › Thiamin diphosphate-binding fold (THDP-binding) › Thiamin diphosphate-binding fold (THDP-binding) › Thiamin diphosphate-binding fold (THDP-binding) › TPP_enzyme_C | 0.51 | 42.0 | 3.19e-01 | 100.0% | 70.6% |