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transactivating_tegument_protein_VP16
Euk-VirSuid_alphaherpesvirus_1
transactivating_tegument_protein_VP16__YP_068327__Suid_alphaherpesvirus_1__10345
Identity
- Accession:
- YP_068327 ↗
- Protein ID:
- transactivating_tegument_protein_VP16
- Kingdom:
- euk
Quality
76.7
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Varicellovirus›
Suid_alphaherpesvirus_1
TaxID: 10345
Cluster
View cluster (32 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 213-289
Domain cluster:
rep: transactivating_tegument_protein_VP16__YP_009252238__Canid_alphaherpesvirus_1__170325__D230-289
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 104.6 | 8.70e-30 | 100.0% | 22.2% |
D2
medium
residues 20-129_309-336
Domain cluster:
rep: transactivating_tegument_protein_VP16__YP_009227280__Macropodid_alphaherpesvirus_1__137443__D26-151
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 97.0 | 1.70e-27 | 81.9% | 29.7% |
D3
medium
residues 130-211_294-308
Domain cluster:
rep: transactivating_tegument_protein_VP16__YP_009176885__Testudinid_alphaherpesvirus_3__2560801__D132-171_186-238_328-350
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 71.0 | 1.50e-19 | 99.0% | 27.1% |
CATH (31)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 16vpA00 | 1.10.1290.10 | Mainly Alpha › Orthogonal Bundle › Conserved core of transcriptional regulatory protein vp16 › Alpha trans-inducing (Alpha-TIF) | 0.96 | 93.0 | 6.17e-01 | 100.0% | 61.7% |
| 2uv8A07 | 6.10.140.1410 | Special › Helix non-globular › Helix Hairpins › | 0.71 | 50.0 | 5.33e-01 | 83.5% | 83.5% |
| 4lwsA00 | 1.10.287.1060 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ESAT-6-like | 0.70 | 47.0 | 4.73e-01 | 71.1% | 68.0% |
| 4fwvA02 | 1.20.120.1680 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › | 0.66 | 55.0 | 5.00e-01 | 92.8% | 88.1% |
| 1jadA00 | 1.20.1230.10 | Mainly Alpha › Up-down Bundle › Phospholipase C Beta; Chain: A › Phospholipase C beta, distal C-terminal domain | 0.65 | 57.0 | 4.34e-01 | 100.0% | 84.3% |
| 3tbiB02 | 6.10.140.1670 | Special › Helix non-globular › Helix Hairpins › | 0.64 | 49.0 | 4.92e-01 | 81.4% | 89.0% |
| 2vkzA02 | 3.40.47.10 | Alpha Beta › 3-Layer(aba) Sandwich › Peroxisomal Thiolase; Chain A, domain 1 › Thiolase/Chalcone synthase | 0.64 | 50.0 | 3.69e-01 | 84.5% | 45.4% |
| 1kmiZ02 | 1.10.287.500 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.64 | 45.0 | 4.05e-01 | 75.3% | 53.7% |
| 1cxzB00 | 1.10.287.160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › HR1 repeat | 0.63 | 40.0 | 4.24e-01 | 100.0% | 72.1% |
| 2qywA00 | 1.20.58.400 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › t-snare proteins | 0.63 | 39.0 | 3.99e-01 | 95.9% | 64.2% |
| 2dw4A03 | 1.10.287.80 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › ATP synthase, gamma subunit, helix hairpin domain | 0.61 | 40.0 | 4.00e-01 | 83.5% | 63.4% |
| 4an8A02 | 1.10.132.100 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.61 | 51.0 | 4.71e-01 | 99.0% | 72.1% |
| 1dd5A01 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.61 | 55.0 | 5.28e-01 | 100.0% | 92.7% |
| 7e84A03 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.59 | 45.0 | 4.26e-01 | 83.5% | 92.7% |
| 3ripA02 | 1.20.120.1900 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Gamma-tubulin complex, C-terminal domain | 0.59 | 47.0 | 3.42e-01 | 86.6% | 88.9% |
| 8ek4A01 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.59 | 52.0 | 4.72e-01 | 99.0% | 85.0% |
| 4dciA00 | 6.10.140.1110 | Special › Helix non-globular › Helix Hairpins › | 0.59 | 46.0 | 4.03e-01 | 84.5% | 76.2% |
| 3edvB01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.58 | 42.0 | 3.73e-01 | 75.3% | 67.6% |
| 4oydB00 | 1.10.132.20 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor | 0.58 | 51.0 | 4.82e-01 | 99.0% | 89.7% |
| 2bdeA03 | 1.20.58.1160 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 37.0 | 4.15e-01 | 92.8% | 83.1% |
| 1bgfA00 | 1.10.532.10 | Mainly Alpha › Orthogonal Bundle › Transcription Factor, Stat-4 › STAT transcription factor, N-terminal domain | 0.56 | 43.0 | 3.95e-01 | 96.9% | 62.9% |
| 2l3lA01 | 1.20.58.1250 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Tubulin Binding Cofactor C, N-terminal domain | 0.55 | 36.0 | 3.54e-01 | 100.0% | 60.4% |
| 4adzA00 | 1.20.58.1000 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Metal-sensitive repressor, helix protomer | 0.55 | 43.0 | 4.47e-01 | 84.5% | 92.2% |
| 4mh6A00 | 1.10.287.1700 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.55 | 43.0 | 3.64e-01 | 83.5% | 82.4% |
| 1m5iA00 | 1.10.287.450 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.53 | 40.0 | 3.89e-01 | 78.4% | 92.4% |
| 2xubA05 | 6.10.140.1450 | Special › Helix non-globular › Helix Hairpins › | 0.53 | 42.0 | 4.26e-01 | 100.0% | 85.4% |
| 1ydxA02 | 1.10.287.1120 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Bipartite methylase S protein | 0.52 | 38.0 | 3.91e-01 | 79.4% | 81.1% |
| 2yxhA00 | 1.10.287.1080 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › MazG-like | 0.52 | 34.0 | 3.31e-01 | 89.7% | 56.6% |
| 1sumB01 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.51 | 43.0 | 4.21e-01 | 94.8% | 83.2% |
| 2oduA02 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.51 | 43.0 | 4.19e-01 | 100.0% | 82.9% |
| 1lkoA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.50 | 45.0 | 3.95e-01 | 99.0% | 87.6% |
ECOD (31)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3404270 | 377.1.1.0 ↗ | few secondary structure elements › Glucocorticoid receptor-like › LIM domain-like › LIM domain-like | 0.78 | 62.0 | 5.61e-01 | 84.5% | 74.6% |
| 5056477 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.74 | 52.0 | 5.45e-01 | 78.4% | 78.9% |
| 5055960 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.67 | 45.0 | 4.24e-01 | 72.2% | 56.7% |
| 3974230 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.65 | 56.0 | 5.53e-01 | 94.8% | 91.4% |
| 3771990 | 3567.1.1.6 ↗ | a+b duplicates or obligate multimers › MPER trimer › MPER trimer › MPER trimer › DGCR6 | 0.65 | 51.0 | 4.73e-01 | 84.5% | 68.8% |
| 3641196 | 5041.1.1.27 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › PRA1 | 0.65 | 46.0 | 4.37e-01 | 74.2% | 93.0% |
| 3740294 | 3826.1.1.0 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) | 0.63 | 54.0 | 4.65e-01 | 93.8% | 74.0% |
| 3240682 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.62 | 43.0 | 4.13e-01 | 71.1% | 63.6% |
| 4076285 | 3755.1.1.12 ↗ | alpha bundles › YscO-like › Putative type III secretion protein YscO-related › Putative type III secretion protein YscO-related › CheZ | 0.62 | 44.0 | 3.90e-01 | 75.3% | 51.4% |
| 3484074 | 192.8.1.0 ↗ | alpha bundles › Long alpha-hairpin › Eukaryotic DNA topoisomerase I, dispensable insert domain › Eukaryotic DNA topoisomerase I, dispensable insert domain | 0.61 | 44.0 | 3.91e-01 | 75.3% | 52.1% |
| 4949396 | 606.1.1.0 ↗ | alpha complex topology › Nop N-terminal domain › Nop N-terminal domain › Nop N-terminal domain | 0.60 | 43.0 | 4.46e-01 | 74.2% | 98.9% |
| 3694833 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.59 | 43.0 | 3.89e-01 | 75.3% | 57.7% |
| 3663289 | 3755.3.1.0 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin | 0.59 | 51.0 | 4.06e-01 | 94.8% | 73.7% |
| 3218921 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.59 | 47.0 | 4.59e-01 | 88.7% | 83.5% |
| 3197615 | 3755.3.1.355 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › Uds1 | 0.58 | 44.0 | 4.03e-01 | 79.4% | 65.6% |
| 3741745 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.58 | 39.0 | 3.48e-01 | 100.0% | 50.8% |
| 4676422 | 3922.1.1.0 ↗ | alpha bundles › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 › Helical domain in structural maintenance of chromosomes protein 3 | 0.58 | 43.0 | 3.51e-01 | 77.3% | 85.7% |
| 4642325 | 5086.1.1.84 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND | 0.57 | 43.0 | 3.93e-01 | 79.4% | 84.6% |
| 3964486 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.57 | 44.0 | 3.77e-01 | 83.5% | 80.0% |
| 3968781 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.57 | 42.0 | 3.74e-01 | 79.4% | 85.5% |
| 5083949 | 5086.1.1.84 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND | 0.56 | 42.0 | 3.83e-01 | 79.4% | 63.1% |
| 5021813 | 5058.1.1.101 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › DUF1622 | 0.55 | 45.0 | 4.41e-01 | 89.7% | 81.9% |
| 3610797 | 376.1.1.22 ↗ | few secondary structure elements › RING/U-box-like › RING/U-box-like › RING/U-box › zf-C3HC4_3 | 0.54 | 42.0 | 3.26e-01 | 83.5% | 38.2% |
| 5012158 | 5058.1.1.0 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region | 0.54 | 41.0 | 4.14e-01 | 94.8% | 85.3% |
| 4029302 | 603.1.1.0 ↗ | alpha bundles › STAT-like › t-snare proteins › t-snare proteins | 0.53 | 43.0 | 3.44e-01 | 86.6% | 81.1% |
| 3930934 | 5054.1.1.8 ↗ | alpha complex topology › Voltage-gated ion channels › Voltage-gated ion channels › Voltage-gated ion channels › Ion_trans_2 | 0.53 | 47.0 | 3.41e-01 | 99.0% | 87.9% |
| 3386594 | 3291.1.1.197 ↗ | alpha bundles › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › Charged multivesicular body protein 3 (CHMP3)-related › MCPsignal | 0.53 | 41.0 | 4.08e-01 | 84.5% | 78.1% |
| 3948872 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.53 | 42.0 | 3.78e-01 | 84.5% | 85.4% |
| 4468076 | 632.22.1.1 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats › EzrA | 0.52 | 34.0 | 3.62e-01 | 70.1% | 75.3% |
| 5049145 | 604.1.1.0 ↗ | alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat | 0.51 | 40.0 | 3.97e-01 | 90.7% | 80.8% |
| 3170239 | 604.12.1.0 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain | 0.50 | 39.0 | 4.11e-01 | 97.9% | 90.0% |