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transactivating_tegument_protein_VP16
Euk-VirGallid_alphaherpesvirus_1
transactivating_tegument_protein_VP16__YP_182343__Gallid_alphaherpesvirus_1__10386
Identity
- Accession:
- YP_182343 ↗
- Protein ID:
- transactivating_tegument_protein_VP16
- Kingdom:
- euk
Quality
70.2
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Iltovirus›
Gallid_alphaherpesvirus_1
TaxID: 10386
Cluster
View cluster (32 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
medium
residues 101-111_166-181_255-340
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 44.0 | 2.40e-11 | 86.7% | 24.2% |
CATH (4)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 16vpA00 | 1.10.1290.10 | Mainly Alpha › Orthogonal Bundle › Conserved core of transcriptional regulatory protein vp16 › Alpha trans-inducing (Alpha-TIF) | 0.90 | 85.0 | 5.99e-01 | 100.0% | 78.8% |
| 4p7oB00 | 3.20.20.80 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Glycosidases | 0.53 | 41.0 | 2.92e-01 | 82.3% | 34.4% |
| 3t8qA02 | 3.20.20.120 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain | 0.51 | 39.0 | 3.06e-01 | 82.3% | 36.6% |
| 3mkcA02 | 3.20.20.120 | Alpha Beta › Alpha-Beta Barrel › TIM Barrel › Enolase-like C-terminal domain | 0.50 | 39.0 | 3.09e-01 | 82.3% | 39.4% |
ECOD (2)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7584 | 816.1.1.1 ↗ | a+b complex topology › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Conserved core of transcriptional regulatory protein vp16 › Alpha_TIF | 0.90 | 85.0 | 6.03e-01 | 100.0% | 80.9% |
| 5055423 | 2002.1.1.452 ↗ | a/b barrels › TIM beta/alpha-barrel › TIM barrels › TIM barrels › Radical_SAM_C | 0.50 | 39.0 | 2.83e-01 | 83.2% | 35.8% |
D2
medium
residues 112-165_182-254
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02232.20 best | Alpha_TIF | 27.1 | 3.30e-06 | 67.7% | 20.7% |
CATH (10)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3lphC00 | 6.10.140.630 | Special › Helix non-globular › Helix Hairpins › | 0.58 | 28.0 | 3.73e-01 | 70.1% | 93.1% |
| 1y1aA02 | 1.10.238.10 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand | 0.57 | 27.0 | 3.10e-01 | 74.8% | 58.6% |
| 3mk7A00 | 1.20.210.10 | Mainly Alpha › Up-down Bundle › Cytochrome C Oxidase; Chain A › Cytochrome c oxidase-like, subunit I domain | 0.53 | 47.0 | 3.25e-01 | 100.0% | 93.3% |
| 2bgcA02 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.53 | 22.0 | 2.43e-01 | 70.9% | 44.6% |
| 5y2vC01 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.52 | 32.0 | 3.76e-01 | 96.1% | 89.4% |
| 2zdiB00 | 1.10.287.370 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.52 | 36.0 | 3.86e-01 | 76.4% | 84.0% |
| 2e1mA05 | 1.10.405.10 | Mainly Alpha › Orthogonal Bundle › Guanine Nucleotide Dissociation Inhibitor; domain 1 › Guanine Nucleotide Dissociation Inhibitor, domain 1 | 0.52 | 28.0 | 3.29e-01 | 71.7% | 73.6% |
| 5g5gA02 | 1.10.150.120 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › [2Fe-2S]-binding domain | 0.51 | 28.0 | 3.28e-01 | 75.6% | 74.4% |
| 5fo5A00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.51 | 32.0 | 3.73e-01 | 98.4% | 90.9% |
| 1fxkB00 | 1.10.287.370 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.51 | 34.0 | 3.65e-01 | 76.4% | 79.8% |
ECOD (16)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3910498 | 103.1.1.38 ↗ | alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain › ELM2 | 0.62 | 32.0 | 3.54e-01 | 88.2% | 59.0% |
| 4006691 | 5058.1.1.2 ↗ | alpha bundles › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › Mechanosensitive channel protein MscS (YggB), transmembrane region › MS_channel_1st | 0.58 | 39.0 | 4.07e-01 | 87.4% | 72.5% |
| 4948599 | 192.2.1.2 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin | 0.58 | 37.0 | 4.33e-01 | 76.4% | 92.2% |
| 3382511 | 2003.1.2.0 ↗ | a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain | 0.56 | 47.0 | 3.31e-01 | 89.8% | 93.6% |
| 3926252 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.56 | 47.0 | 4.36e-01 | 91.3% | 76.4% |
| 3843567 | 3554.1.1.4 ↗ | a+b duplicates or obligate multimers › protein of unknown function (eca1910) › protein of unknown function (eca1910) › protein of unknown function (eca1910) › TF_AP-2 | 0.56 | 31.0 | 3.25e-01 | 100.0% | 58.3% |
| 3469895 | 5001.1.1.0 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like | 0.53 | 44.0 | 3.28e-01 | 89.8% | 34.8% |
| 4020856 | 650.1.1.0 ↗ | alpha bundles › Chaperone J-domain › Chaperone J-domain › Chaperone J-domain | 0.52 | 34.0 | 3.41e-01 | 77.2% | 61.5% |
| 3292735 | 306.7.1.1 ↗ | a+b two layers › Glucose permease domain IIB-like › Trigger factor ribosome-binding domain › Trigger factor ribosome-binding domain › Trigger_N | 0.52 | 35.0 | 3.52e-01 | 96.1% | 65.2% |
| 5081618 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.52 | 32.0 | 3.34e-01 | 76.4% | 65.0% |
| 4554418 | 1075.3.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC importer transmembrane domain fold › Type I ABC importer transmembrane domain fold | 0.52 | 46.0 | 3.58e-01 | 99.2% | 52.2% |
| 4473250 | 2484.1.1.37 ↗ | mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › Pan_kinase | 0.51 | 36.0 | 3.37e-01 | 96.9% | 58.7% |
| 4963777 | 604.12.1.137 ↗ | alpha bundles › Spectrin repeat-like › MIT domain › MIT domain › DUF373 | 0.51 | 38.0 | 3.63e-01 | 87.4% | 66.7% |
| 1263136 | 3686.1.1.1 ↗ | alpha arrays › Nitrile hydratase subunit beta N-termial domain › Nitrile hydratase subunit beta N-termial domain › Nitrile hydratase subunit beta N-termial domain › NHase_beta_N | 0.51 | 24.0 | 2.43e-01 | 73.2% | 40.0% |
| 4999971 | 192.2.1.0 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin | 0.50 | 33.0 | 3.83e-01 | 77.2% | 93.3% |
| 3579266 | 5055.1.1.11 ↗ | extended segments › Small-conductance potassium channel › Small-conductance potassium channel › Small-conductance potassium channel › Cation_ATPase_N | 0.50 | 28.0 | 3.59e-01 | 93.7% | 94.7% |