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transcriptional_regulator_ICP4

Euk-Vir

Human_alphaherpesvirus_3

transcriptional_regulator_ICP4__NP_040184__Human_alphaherpesvirus_3__10335

Identity

Accession:: NP_040184 ↗
Protein ID:: transcriptional_regulator_ICP4
Kingdom:: euk

Quality

53.0 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Human_alphaherpesvirus_3

TaxID: 10335

Cluster

View cluster (4 members)

3D Structure

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Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 469-521_548-562

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03584.21 best	Herpes_ICP4_N	80.0	2.80e-22	100.0%	37.9%

CATH (2)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1e29A00	1.10.760.10	Mainly Alpha › Orthogonal Bundle › Cytochrome Bc1 Complex; Chain D, domain 2 › Cytochrome c-like domain	0.56	43.0	3.55e-01	86.8%	80.0%
3lmmA03	3.30.565.60	Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 ›	0.52	41.0	3.15e-01	88.2%	97.7%

ECOD (4)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2080131	4189.1.1.1 ↗	alpha arrays › ICP4 DNA-binding domain › ICP4 DNA-binding domain › ICP4 DNA-binding domain › Herpes_ICP4_N	0.82	74.0	5.22e-01	100.0%	47.2%
5032641	101.1.1.40 ↗	alpha arrays › HTH › HTH › Three-helical HTH › Recombinase	0.52	40.0	3.41e-01	89.7%	51.8%
4296280	7523.1.1.58 ↗	a/b three-layered sandwiches › Periplasmic binding protein-like II › Periplasmic binding protein-like II › Periplasmic binding protein-like II › DUF5396	0.51	42.0	2.60e-01	92.6%	28.8%
3742987	5045.1.1.1 ↗	alpha bundles › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › F1F0 ATP synthase subunit A › ATP-synt_A	0.50	41.0	2.85e-01	92.6%	91.2%

D2 medium residues 522-547_563-630

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__NP_077476__Cercopithecine_alphaherpesvirus_9__35246__D526-552_581-620

Pfam (2)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03584.21 best	Herpes_ICP4_N	112.1	3.80e-32	72.3%	37.9%
PF03584.21	Herpes_ICP4_N	29.3	1.00e-06	35.1%	16.7%

D3 medium residues 740-810_822-862_915-974

PDB

Domain cluster: representative

Pfam (3)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	88.0	8.60e-25	39.0%	13.5%
PF03585.20	Herpes_ICP4_C	95.6	4.10e-27	38.4%	14.0%
PF03585.20	Herpes_ICP4_C	59.4	4.00e-16	24.4%	8.6%

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2c53A00	3.40.470.10	Alpha Beta › 3-Layer(aba) Sandwich › Uracil-DNA Glycosylase, subunit E › Uracil-DNA glycosylase-like domain	0.72	55.0	4.93e-01	77.9%	85.5%

D4 medium residues 863-914_975-997

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	90.6	1.40e-25	72.0%	11.9%

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1yt3A01	3.30.420.10	Alpha Beta › 2-Layer Sandwich › Nucleotidyltransferase; domain 5 › Ribonuclease H-like superfamily/Ribonuclease H	0.53	36.0	2.78e-01	70.7%	69.1%

D5 medium residues 1029-1108

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	140.8	7.80e-41	100.0%	18.0%

D6 medium residues 1109-1197

PDB