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transcriptional_regulator_ICP4

Euk-Vir

Bovine_alphaherpesvirus_1

transcriptional_regulator_ICP4__NP_045375__Bovine_alphaherpesvirus_1__10320

Identity

Accession:
NP_045375 ↗
Protein ID:
transcriptional_regulator_ICP4
Kingdom:
euk

Quality

58.4 mean pLDDT

3D Structure

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 326-477
PDB
D2 high residues 488-660
PDB
CATH (26)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
1sumB01 1.20.58.220 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 0.70 36.0 4.60e-01 79.8% 82.2%
4iu9B02 1.20.1250.20 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains 0.66 46.0 4.40e-01 70.5% 79.3%
2yfaA02 1.20.1440.210 Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › 0.63 32.0 3.82e-01 76.3% 71.6%
4x28C03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.61 34.0 3.73e-01 86.1% 65.0%
7kypB01 1.10.3470.10 Mainly Alpha › Orthogonal Bundle › ABC transporter involved in vitamin B12 uptake, BtuC › ABC transporter involved in vitamin B12 uptake, BtuC 0.60 48.0 4.13e-01 83.8% 91.7%
4l8iB00 1.10.132.20 Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › Ribosome-recycling factor 0.59 35.0 4.22e-01 79.8% 88.4%
2jifA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.58 34.0 3.64e-01 85.5% 64.3%
2cmrA00 1.20.58.1860 Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › 0.58 41.0 3.98e-01 98.8% 64.6%
2x1lA03 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.58 46.0 4.61e-01 81.5% 93.0%
5figA00 1.20.1270.360 Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › 0.58 31.0 4.13e-01 73.4% 93.0%
5zw7A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.57 34.0 3.67e-01 86.7% 67.1%
1sj7C00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.57 42.0 4.30e-01 75.1% 89.8%
1egdA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.57 34.0 3.80e-01 88.4% 73.8%
1gaxA02 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.56 45.0 4.11e-01 83.8% 65.6%
8hk0C01 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.56 34.0 3.64e-01 86.1% 68.7%
3kflA03 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.56 45.0 4.56e-01 86.1% 91.4%
1n4kA02 1.25.10.30 Mainly Alpha › Alpha Horseshoe › Leucine-rich Repeat Variant › IP3 receptor type 1 binding core, RIH domain 0.55 32.0 3.41e-01 86.1% 63.5%
1qdbA02 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.55 38.0 4.12e-01 86.1% 83.9%
3pivA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.55 39.0 4.17e-01 79.2% 81.4%
2l7nA00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.54 39.0 4.03e-01 74.0% 85.1%
3zgzA04 1.10.730.10 Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 0.53 42.0 4.17e-01 83.8% 79.1%
1siqA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 35.0 3.68e-01 100.0% 74.8%
4xvxA03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 34.0 3.71e-01 100.0% 77.6%
2pg0A03 1.20.140.10 Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 0.52 34.0 3.72e-01 100.0% 77.9%
2l10A00 1.20.1420.10 Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain 0.51 41.0 4.32e-01 91.9% 91.8%
1f6fA00 1.20.1250.10 Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › 0.51 37.0 3.68e-01 79.8% 69.4%
ECOD (56)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
3948660 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.72 50.0 4.85e-01 70.5% 77.9%
3513146 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.72 51.0 4.72e-01 71.7% 72.6%
3591624 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.71 50.0 4.64e-01 71.7% 77.7%
3954846 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.71 51.0 4.78e-01 72.8% 82.4%
4577438 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.71 51.0 4.31e-01 72.8% 56.7%
3285842 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.70 49.0 4.78e-01 71.7% 83.2%
3972582 5050.1.1.60 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_3 0.69 49.0 4.69e-01 72.3% 76.0%
3695873 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.69 49.0 3.91e-01 72.3% 46.1%
4947878 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.69 48.0 4.78e-01 71.1% 84.4%
3602104 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.69 49.0 4.66e-01 72.3% 74.5%
3556701 174.1.1.0 few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain 0.69 35.0 3.72e-01 80.3% 54.2%
4451042 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.68 57.0 4.09e-01 86.7% 92.0%
3987427 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.68 47.0 4.57e-01 71.1% 75.9%
4024207 5050.1.1.1 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.67 47.0 4.11e-01 70.5% 61.6%
3181920 5050.1.1.12 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › TRI12 0.67 47.0 3.98e-01 71.7% 52.8%
3489137 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.67 47.0 4.49e-01 72.3% 76.1%
4961715 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.66 47.0 4.49e-01 72.8% 73.2%
3971899 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.66 47.0 4.44e-01 71.7% 73.4%
3970116 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.66 46.0 4.44e-01 71.1% 74.2%
3789167 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.66 47.0 4.25e-01 72.3% 70.2%
3385721 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.65 46.0 4.53e-01 71.1% 82.2%
3240066 1188.1.1.1 alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Zip 0.65 48.0 4.21e-01 76.3% 93.8%
5053012 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.65 47.0 4.41e-01 73.4% 72.9%
3301886 5050.1.1.1 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr 0.65 46.0 4.04e-01 71.7% 62.4%
3776995 1188.1.1.1 alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Zip 0.64 48.0 4.16e-01 76.3% 92.7%
4010186 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.64 46.0 4.45e-01 73.4% 73.8%
3688002 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.64 45.0 4.24e-01 72.3% 69.3%
4961016 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.64 45.0 4.23e-01 72.3% 74.2%
4017092 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.64 51.0 4.35e-01 85.0% 99.6%
3261141 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.64 46.0 4.24e-01 74.0% 74.5%
3403194 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.63 45.0 4.20e-01 72.3% 72.9%
3228201 5050.1.1.0 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter 0.62 44.0 4.34e-01 71.7% 73.5%
4125686 140.1.1.5 alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon_1 0.60 48.0 4.78e-01 83.8% 85.6%
4955097 1188.1.1.3 alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Mntp 0.59 44.0 4.31e-01 76.3% 74.6%
None 0.59 47.0 4.53e-01 83.8% 77.5%
3730569 5050.1.1.9 alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 0.58 47.0 4.16e-01 85.5% 88.2%
3988781 604.6.1.63 alpha bundles › Spectrin repeat-like › GAT-like domain › GAT-like domain › DUF3169 0.58 38.0 4.24e-01 83.2% 84.4%
3851770 150.3.1.1 alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › 4-helical cytokines › 4-helical cytokine › Hormone_1 0.57 45.0 4.45e-01 83.2% 98.4%
4302177 140.1.1.7 alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 0.56 38.0 4.19e-01 85.5% 84.3%
5005480 604.1.1.0 alpha bundles › Spectrin repeat-like › Spectrin repeat › Spectrin repeat 0.56 37.0 3.68e-01 80.3% 65.1%
5048853 1079.1.1.8 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › LysE 0.56 41.0 3.84e-01 76.3% 73.5%
3251835 601.1.1.6 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › TLN1-like_RS 0.56 40.0 4.20e-01 73.4% 91.6%
3251842 601.1.1.7 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › alpha-catenin/vinculin › Talin_IBS2B 0.56 39.0 4.14e-01 70.5% 88.0%
5018393 5059.1.1.1 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.55 45.0 3.71e-01 84.4% 65.4%
5071165 633.23.1.0 alpha bundles › Bromodomain-like › Claudin › Claudin 0.55 33.0 3.58e-01 72.3% 68.7%
3632945 109.4.1.162 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Nup192 0.54 45.0 3.82e-01 93.6% 55.8%
3925082 5059.1.1.5 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › UAA 0.54 44.0 3.79e-01 84.4% 75.8%
3964803 5059.1.1.1 alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA 0.54 43.0 3.58e-01 82.7% 64.5%
3526586 109.4.1.0 alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat 0.52 39.0 3.84e-01 100.0% 73.3%
3620054 140.1.1.0 alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases 0.52 41.0 4.08e-01 83.2% 82.7%
4058840 140.1.1.7 alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › DALR_2 0.52 43.0 4.43e-01 87.3% 94.4%
3903061 601.1.3.2 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › A middle domain of Talin 1 › GCIP_N 0.52 39.0 4.09e-01 78.0% 87.5%
3644387 601.1.2.81 alpha bundles › Four-helical up-and-down bundle › alpha-catenin-related › I/LWEQ domain (Pfam 01608) › Serinc 0.51 38.0 4.00e-01 75.7% 88.0%
5027277 1079.1.1.0 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA 0.51 38.0 3.61e-01 78.0% 73.3%
3284576 633.6.1.1 alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1 0.50 33.0 3.44e-01 100.0% 69.7%
4571267 1079.1.1.13 alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Mntp 0.50 37.0 3.69e-01 76.3% 73.6%
D3 medium residues 828-898
PDB
Domain cluster: representative
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03585.20 best Herpes_ICP4_C 82.8 3.10e-23 93.0% 13.7%
CATH (2)
Domain IDClass IDClassificationTM-scoreBitsE-valueQ covT cov
8alzB08 1.10.3380.10 Mainly Alpha › Orthogonal Bundle › Sec63 N-terminal domain-like fold › Sec63 N-terminal domain-like domain 0.54 37.0 3.11e-01 71.8% 59.5%
1y1pA01 3.40.50.720 Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain 0.51 41.0 2.78e-01 94.4% 92.4%
ECOD (4)
UIDF-IDClassificationTM-scoreBitsE-valueQ covT cov
4602919 2484.1.1.40 mixed a+b and a/b › Ribonuclease H-like › Ribonuclease H-like › Ribonuclease H-like › RuvX 0.62 45.0 3.56e-01 76.1% 84.0%
3811636 282.1.1.0 a+b duplicates or obligate multimers › CBS-domain › CBS-domain › CBS-domain 0.51 39.0 3.09e-01 85.9% 52.5%
3814488 101.1.10.0 alpha arrays › HTH › HTH › Cyclin-like 0.50 40.0 3.59e-01 93.0% 97.3%
3562181 148.1.3.0 alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain 0.50 43.0 4.03e-01 100.0% 95.6%
D4 medium residues 899-1108
PDB
Pfam (1)
AccessionNameScoreE-valueQ covHMM cov
PF03585.20 best Herpes_ICP4_C 288.0 1.80e-85 99.5% 45.7%