transcriptional_regulator_ICP4

Euk-Vir

Cercopithecine_alphaherpesvirus_9

transcriptional_regulator_ICP4__NP_077476__Cercopithecine_alphaherpesvirus_9__35246

Identity

53.5 mean pLDDT

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Cercopithecine_alphaherpesvirus_9

TaxID: 35246

Singleton — not in a non-trivial cluster

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high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 medium residues 457-525_553-580

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03584.21 best	Herpes_ICP4_N	76.6	3.10e-21	74.2%	39.7%

ECOD (1)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2080131	4189.1.1.1 ↗	alpha arrays › ICP4 DNA-binding domain › ICP4 DNA-binding domain › ICP4 DNA-binding domain › Herpes_ICP4_N	0.83	78.0	6.00e-01	100.0%	62.4%

D2 medium residues 526-552_581-620

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03584.21 best	Herpes_ICP4_N	68.1	1.30e-18	62.7%	23.0%

CATH (7)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4eqyA02	1.20.1180.10	Mainly Alpha › Up-down Bundle › Udp N-acetylglucosamine O-acyltransferase; Domain 2 › Udp N-acetylglucosamine O-acyltransferase, C-terminal domain	0.60	44.0	4.39e-01	89.6%	74.3%
2ewfA03	3.40.91.50	Alpha Beta › 3-Layer(aba) Sandwich › Restriction Endonuclease ›	0.60	49.0	3.44e-01	92.5%	59.6%
4nv0A02	1.10.150.340	Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Pyrimidine 5'-nucleotidase (UMPH-1), N-terminal domain	0.58	43.0	4.03e-01	79.1%	79.3%
3mvpA02	1.10.357.10	Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2	0.56	48.0	3.82e-01	100.0%	69.8%
5tkyA05	1.20.1270.10	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 ›	0.56	44.0	4.07e-01	100.0%	66.7%
2zxqA06	1.20.1270.70	Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle	0.55	44.0	4.46e-01	100.0%	90.9%
1c1dA02	3.40.50.720	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain	0.54	45.0	3.27e-01	95.5%	85.6%

ECOD (7)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2080131	4189.1.1.1 ↗	alpha arrays › ICP4 DNA-binding domain › ICP4 DNA-binding domain › ICP4 DNA-binding domain › Herpes_ICP4_N	0.88	81.0	5.62e-01	100.0%	47.7%
3442159	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.63	52.0	4.62e-01	100.0%	63.2%
3167091	148.1.1.12 ↗	alpha arrays › Histone-like › Histone-related › Histone › Bromo_TP	0.58	38.0	3.51e-01	100.0%	51.1%
3221091	206.1.1.1 ↗	a+b complex topology › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase/SAICAR synthase/ATP-grasp › Protein kinase › Pkinase	0.56	47.0	3.44e-01	98.5%	78.0%
3733247	2003.1.2.0 ↗	a/b three-layered sandwiches › Rossmann-like › Rossmann-related › FAD/NAD(P)-binding domain	0.56	50.0	3.29e-01	97.0%	30.6%
4955981	101.1.2.875 ↗	alpha arrays › HTH › HTH › winged helix domain › HTH_3	0.56	48.0	4.25e-01	98.5%	91.0%
3767940	192.15.1.43 ↗	alpha bundles › Long alpha-hairpin › Endosomal sorting complex assembly domains › Endosomal sorting complex assembly domains › PH_19	0.52	45.0	4.25e-01	98.5%	100.0%

D3 medium residues 709-812

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_009252288__Canid_alphaherpesvirus_1__170325__D900-996

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	110.1	1.60e-31	90.4%	24.8%

D4 medium residues 813-1008

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_009137226__Human_alphaherpesvirus_2__10310__D928-1142

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	302.7	6.10e-90	100.0%	42.8%