transcriptional_regulator_ICP4

Euk-Vir

Macacine_alphaherpesvirus_1

transcriptional_regulator_ICP4__NP_851933__Macacine_alphaherpesvirus_1__10325

Identity

64.8 mean pLDDT

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Simplexvirus› Macacine_alphaherpesvirus_1

TaxID: 10325

View cluster (8 members)

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high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 285-457

PDB

Domain cluster: rep: hypothetical_protein__YP_009230205__Leporid_alphaherpesvirus_4__481315__D118-301

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03584.21 best	Herpes_ICP4_N	261.3	5.90e-78	99.4%	98.9%

D2 high residues 485-501_526-654

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_009137226__Human_alphaherpesvirus_2__10310__D637-670_685-768

D3 medium residues 749-813

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	69.4	3.70e-19	100.0%	17.3%

CATH (5)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
7eptR01	1.20.1070.10	Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins	0.62	45.0	3.10e-01	80.0%	96.1%
5a2gA00	3.40.50.1820	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain	0.60	45.0	2.75e-01	84.6%	45.3%
1y9zB01	3.40.50.200	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidase S8/S53 domain	0.53	44.0	2.90e-01	95.4%	46.0%
1sh7A00	3.40.50.200	Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Peptidase S8/S53 domain	0.52	42.0	2.81e-01	90.8%	45.9%
1xqoA01	1.10.1670.10	Mainly Alpha › Orthogonal Bundle › Endonuclease Iii, domain 2 › Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)	0.50	42.0	3.57e-01	98.5%	70.3%

ECOD (7)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4952353	2004.1.1.49 ↗	a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › UvrD-helicase	0.57	48.0	2.70e-01	93.8%	19.9%
3562181	148.1.3.0 ↗	alpha arrays › Histone-like › Histone-related › AAA+ ATPase lid domain	0.57	41.0	3.78e-01	87.7%	56.7%
3508088	7579.1.1.89 ↗	a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › COesterase, BD-FAE	0.56	42.0	2.48e-01	84.6%	48.7%
5015222	129.1.1.8 ↗	alpha arrays › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › 6-phosphogluconate dehydrogenase C-terminal domain-like › HMD	0.56	40.0	3.37e-01	76.9%	65.2%
4950208	4333.1.1.1 ↗	a+b complex topology › DNA methylase specificity domain › DNA methylase specificity domain › DNA methylase specificity domain › Methylase_S	0.54	43.0	3.15e-01	87.7%	57.8%
5046099	213.1.1.1 ↗	a+b three layers › Nat/Ivy › Acyl-CoA N-acyltransferases (Nat) › Acyl-CoA N-acyltransferases (Nat) › Acetyltransf_1	0.53	41.0	3.32e-01	90.8%	73.8%
3237653	109.26.1.1 ↗	alpha superhelices › Repetitive alpha hairpins › Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains › Nuclear pore complex component Nup133/Nup170/Nup157 C-terminal domains › Nucleoporin_C	0.52	37.0	2.15e-01	80.0%	18.5%

D4 medium residues 814-1015

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_009137226__Human_alphaherpesvirus_2__10310__D928-1142

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	322.9	4.50e-96	100.0%	45.7%

D5 medium residues 1016-1132

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_002333545__Equid_alphaherpesvirus_9__55744__D1274-1352_1389-1419

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	140.6	9.20e-41	99.2%	25.0%