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transcriptional_regulator_ICP4
Euk-VirHuman_alphaherpesvirus_2
transcriptional_regulator_ICP4__YP_009137226__Human_alphaherpesvirus_2__10310
Identity
- Accession:
- YP_009137226 ↗
- Protein ID:
- transcriptional_regulator_ICP4
- Kingdom:
- euk
Quality
60.4
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Human_alphaherpesvirus_2
TaxID: 10310
Cluster
View cluster (8 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 349-542
Domain cluster:
rep: hypothetical_protein__YP_009230205__Leporid_alphaherpesvirus_4__481315__D118-301
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03584.21 best | Herpes_ICP4_N | 279.3 | 1.70e-83 | 89.2% | 100.0% |
D2
high
residues 928-1142
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03585.20 best | Herpes_ICP4_C | 377.3 | 1.40e-112 | 100.0% | 48.0% |
CATH (13)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 5c5dD00 | 3.40.50.1970 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › | 0.58 | 38.0 | 4.43e-01 | 84.7% | 89.3% |
| 5ibqA01 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 34.0 | 4.24e-01 | 80.5% | 92.5% |
| 4ru1A01 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.58 | 34.0 | 4.19e-01 | 80.0% | 90.0% |
| 2c53A00 | 3.40.470.10 | Alpha Beta › 3-Layer(aba) Sandwich › Uracil-DNA Glycosylase, subunit E › Uracil-DNA glycosylase-like domain | 0.57 | 53.0 | 5.20e-01 | 98.6% | 100.0% |
| 2i2xB02 | 3.40.50.280 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain | 0.57 | 33.0 | 4.07e-01 | 79.5% | 89.1% |
| 3lyuA01 | 3.40.50.80 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module | 0.56 | 29.0 | 3.86e-01 | 87.4% | 92.9% |
| 2zjgA02 | 3.40.640.10 | Alpha Beta › 3-Layer(aba) Sandwich › Aspartate Aminotransferase; domain 2 › Type I PLP-dependent aspartate aminotransferase-like (Major domain) | 0.56 | 33.0 | 3.14e-01 | 89.3% | 48.4% |
| 1wu2A01 | 3.40.980.10 | Alpha Beta › 3-Layer(aba) Sandwich › Molybdenum Cofactor Biosythetic Enzyme; Chain A › MoaB/Mog-like domain | 0.56 | 34.0 | 4.01e-01 | 80.9% | 86.1% |
| 1bmtA02 | 3.40.50.280 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Cobalamin-binding domain | 0.55 | 33.0 | 3.83e-01 | 79.5% | 81.0% |
| 2iufA03 | 3.40.50.880 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Class I glutamine amidotransferase (GATase) domain | 0.51 | 35.0 | 4.04e-01 | 80.5% | 93.2% |
| 2x7xA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.51 | 28.0 | 3.46e-01 | 72.1% | 84.1% |
| 6oz7B00 | 3.40.50.720 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › NAD(P)-binding Rossmann-like Domain | 0.50 | 36.0 | 3.52e-01 | 87.9% | 66.1% |
| 4rsmA02 | 3.40.50.2300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Response regulator | 0.50 | 29.0 | 3.37e-01 | 74.4% | 78.0% |
ECOD (8)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3273876 | 7569.1.1.0 ↗ | a/b three-layered sandwiches › Uracil-DNA glycosylase-like › Uracil-DNA glycosylase-like › Uracil-DNA glycosylase-like | 0.61 | 56.0 | 5.38e-01 | 97.7% | 92.7% |
| 4168074 | 7569.1.1.1 ↗ | a/b three-layered sandwiches › Uracil-DNA glycosylase-like › Uracil-DNA glycosylase-like › Uracil-DNA glycosylase-like › UDG | 0.60 | 55.0 | 5.28e-01 | 96.3% | 96.2% |
| 3592251 | 7569.1.1.0 ↗ | a/b three-layered sandwiches › Uracil-DNA glycosylase-like › Uracil-DNA glycosylase-like › Uracil-DNA glycosylase-like | 0.59 | 55.0 | 5.37e-01 | 99.5% | 91.5% |
| 419706 | 2007.1.9.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › N5-CAIR mutase (phosphoribosylaminoimidazole carboxylase, PurE) › AIRC | 0.58 | 38.0 | 4.40e-01 | 84.7% | 89.3% |
| 5033064 | 7512.1.1.15 ↗ | a/b three-layered sandwiches › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › UDP-Glycosyltransferase/glycogen phosphorylase › Glyphos_transf | 0.55 | 35.0 | 3.83e-01 | 82.8% | 75.6% |
| 5054183 | 2488.1.1.5 ↗ | a/b three-layered sandwiches › alpha/beta knot › alpha/beta knot › alpha/beta knot › SPOUT_MTase | 0.52 | 29.0 | 3.83e-01 | 82.8% | 100.0% |
| 2772173 | 2007.1.11.1 ↗ | a/b three-layered sandwiches › Flavodoxin-like › Class I glutamine amidotransferase-like › L-fucose isomerase, N-terminal and second domains › Arabinose_Isome | 0.52 | 38.0 | 4.22e-01 | 80.9% | 93.7% |
| 3218463 | 2006.1.6.0 ↗ | a/b three-layered sandwiches › HAD domain-like › HAD domain-related › vWA-like | 0.51 | 38.0 | 4.01e-01 | 77.2% | 88.0% |
D3
medium
residues 637-670_685-768
Domain cluster:
representative
CATH (15)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 1m56C02 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.62 | 47.0 | 3.94e-01 | 78.8% | 64.3% |
| 1wp1B01 | 1.20.1600.10 | Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) | 0.62 | 45.0 | 3.13e-01 | 74.6% | 65.1% |
| 3ezuA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.59 | 52.0 | 4.52e-01 | 96.6% | 92.3% |
| 1qdbA02 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.58 | 42.0 | 3.92e-01 | 73.7% | 71.3% |
| 3ousA00 | 1.10.287.70 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.58 | 37.0 | 4.31e-01 | 79.7% | 92.7% |
| 3ihuA02 | 1.20.120.530 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › GntR ligand-binding domain-like | 0.57 | 38.0 | 3.65e-01 | 70.3% | 57.6% |
| 5figA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.56 | 41.0 | 4.42e-01 | 85.6% | 89.0% |
| 1egdA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 45.0 | 4.21e-01 | 84.7% | 85.8% |
| 1ivhA03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.56 | 46.0 | 4.30e-01 | 87.3% | 85.8% |
| 2om6A02 | 1.10.150.400 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.55 | 35.0 | 4.17e-01 | 94.1% | 96.2% |
| 3kavA00 | 1.20.1270.360 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.55 | 41.0 | 4.44e-01 | 85.6% | 92.2% |
| 4x28C03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.53 | 43.0 | 4.07e-01 | 87.3% | 83.9% |
| 3v5uA02 | 1.20.1420.30 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › NCX, central ion-binding region | 0.53 | 47.0 | 3.86e-01 | 100.0% | 70.6% |
| 6cnzF00 | 1.20.59.10 | Mainly Alpha › Up-down Bundle › Chorismate Mutase Domain, subunit A › Chorismate mutase | 0.53 | 45.0 | 4.14e-01 | 94.9% | 99.4% |
| 2fzfA01 | 1.20.1260.10 | Mainly Alpha › Up-down Bundle › Ferritin › Ferritin, core subunit, four-helix bundle | 0.52 | 48.0 | 4.39e-01 | 99.2% | 84.0% |
ECOD (27)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3379165 | 3890.1.1.1 ↗ | alpha bundles › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Transmembrane Bax inhibitor motif (TMBIM) proteins › Bax1-I | 0.68 | 58.0 | 4.51e-01 | 94.1% | 97.0% |
| 3700052 | 5050.1.1.4 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nucleoside_tran | 0.66 | 48.0 | 4.80e-01 | 75.4% | 92.5% |
| 4973816 | 4323.1.1.0 ↗ | alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C | 0.65 | 49.0 | 4.60e-01 | 78.8% | 92.4% |
| 4943088 | 4323.1.1.0 ↗ | alpha bundles › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C › helical bundle domain in vacuolar ATP synthase subunit C | 0.63 | 48.0 | 4.43e-01 | 79.7% | 92.7% |
| 3974092 | 5085.1.1.1 ↗ | a+b duplicates or obligate multimers › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › OEP | 0.63 | 45.0 | 3.05e-01 | 74.6% | 60.7% |
| 3654118 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.62 | 50.0 | 4.23e-01 | 89.0% | 70.0% |
| 1319990 | 5085.1.1.1 ↗ | a+b duplicates or obligate multimers › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP) › OEP | 0.60 | 44.0 | 3.00e-01 | 75.4% | 60.4% |
| 3865282 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.60 | 42.0 | 3.08e-01 | 72.0% | 92.2% |
| 3277476 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.57 | 46.0 | 4.23e-01 | 84.7% | 70.7% |
| 3288486 | 628.1.1.1 ↗ | alpha bundles › Fatty acid responsive transcription factor FadR, C-terminal domain › Fatty acid responsive transcription factor FadR, C-terminal domain › Fatty acid responsive transcription factor FadR, C-terminal domain › FCD | 0.56 | 41.0 | 3.91e-01 | 77.1% | 66.0% |
| 5045823 | 633.21.1.49 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › PF26247 | 0.56 | 45.0 | 4.54e-01 | 85.6% | 95.0% |
| 5071165 | 633.23.1.0 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin | 0.56 | 42.0 | 3.90e-01 | 79.7% | 83.3% |
| 3967016 | 633.6.1.1 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1 | 0.55 | 44.0 | 3.97e-01 | 84.7% | 70.9% |
| 3288766 | 633.6.1.1 ↗ | alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1 | 0.55 | 43.0 | 4.18e-01 | 84.7% | 89.6% |
| 3400366 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.54 | 42.0 | 3.94e-01 | 79.7% | 82.9% |
| 3823576 | 633.4.1.1 ↗ | alpha bundles › Bromodomain-like › Plant invertase/pectin methylesterase inhibitor › Plant invertase/pectin methylesterase inhibitor › PMEI | 0.54 | 42.0 | 3.87e-01 | 82.2% | 80.5% |
| 3598975 | 150.1.1.0 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin | 0.54 | 40.0 | 3.59e-01 | 78.8% | 63.5% |
| 3509307 | 174.1.1.0 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain | 0.53 | 44.0 | 3.80e-01 | 86.4% | 73.7% |
| 4999626 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.53 | 44.0 | 3.32e-01 | 89.8% | 76.2% |
| 4972169 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.53 | 40.0 | 4.04e-01 | 79.7% | 85.8% |
| 4486492 | 3239.1.1.1 ↗ | alpha complex topology › Cas1 › Cas1 › Cas1 › Cas_Cas1 | 0.53 | 41.0 | 3.03e-01 | 83.9% | 53.6% |
| 3895743 | 3615.1.1.7 ↗ | alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › CD20 | 0.53 | 42.0 | 3.62e-01 | 85.6% | 81.6% |
| 3765032 | 633.23.1.34 ↗ | alpha bundles › Bromodomain-like › Claudin › Claudin › CD20 | 0.52 | 41.0 | 3.82e-01 | 82.2% | 80.7% |
| 3611030 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.52 | 40.0 | 2.83e-01 | 81.4% | 84.9% |
| 3917126 | 174.1.1.33 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Erg28 | 0.51 | 41.0 | 3.81e-01 | 85.6% | 75.3% |
| 3399701 | 174.1.1.1 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin | 0.51 | 40.0 | 3.82e-01 | 83.1% | 77.9% |
| 3664210 | 5059.1.1.0 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter | 0.51 | 45.0 | 3.45e-01 | 100.0% | 62.1% |
D4
medium
residues 878-927
Domain cluster:
rep: transcriptional_regulator_ICP4__NP_851933__Macacine_alphaherpesvirus_1__10325__D749-813
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03585.20 best | Herpes_ICP4_C | 71.6 | 8.10e-20 | 100.0% | 10.8% |