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transcriptional_regulator_ICP4

Euk-Vir

Canid_alphaherpesvirus_1

transcriptional_regulator_ICP4__YP_009252288__Canid_alphaherpesvirus_1__170325

Identity

Accession:: YP_009252288 ↗
Protein ID:: transcriptional_regulator_ICP4
Kingdom:: euk

Quality

60.8 mean pLDDT

Taxonomy

Heunggongvirae› Peploviricota› Herviviricetes› Herpesvirales› Orthoherpesviridae› Varicellovirus› Canid_alphaherpesvirus_1

TaxID: 170325

Cluster

View cluster (12 members)

3D Structure

Download PDB Download Scores JSON

Domains

high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.

D1 high residues 432-583

PDB

Domain cluster: rep: hypothetical_protein__YP_009230205__Leporid_alphaherpesvirus_4__481315__D118-301

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03584.21 best	Herpes_ICP4_N	200.4	3.00e-59	100.0%	88.5%

D2 high residues 613-626_642-789

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_164516__Cercopithecine_alphaherpesvirus_2__10317__D470-643

CATH (18)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
1aepA00	1.20.120.20	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein	0.66	36.0	3.69e-01	78.4%	54.9%
1t72A02	1.20.58.220	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2	0.62	36.0	4.50e-01	78.4%	94.9%
2x1lA03	1.10.730.10	Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1	0.59	49.0	4.88e-01	90.7%	93.0%
1hciA03	1.20.58.60	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.59	37.0	4.28e-01	77.2%	85.8%
1oxjA02	1.25.40.170	Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Smaug, PHAT domain	0.58	33.0	3.92e-01	98.1%	79.8%
1orjD00	1.20.120.340	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS	0.58	34.0	3.85e-01	88.9%	75.2%
7zxkC01	1.20.1250.10	Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; ›	0.57	40.0	4.15e-01	70.4%	98.0%
2cmrA00	1.20.58.1860	Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 ›	0.57	43.0	4.08e-01	96.3%	65.6%
3kflA03	1.10.730.10	Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1	0.56	47.0	4.61e-01	91.4%	89.7%
1yo7A00	1.20.120.230	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like	0.56	34.0	3.92e-01	77.2%	82.5%
1sziA02	1.20.120.340	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS	0.55	33.0	3.54e-01	89.5%	67.9%
5k3hB04	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.55	33.0	3.59e-01	86.4%	71.4%
1yc9A01	1.20.1600.10	Mainly Alpha › Up-down Bundle › Outer membrane efflux proteins (OEP) › Outer membrane efflux proteins (OEP)	0.54	32.0	2.51e-01	73.5%	29.1%
1egdA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.53	35.0	3.76e-01	84.6%	76.6%
6adqG01	1.20.120.80	Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle	0.52	39.0	3.79e-01	77.8%	99.4%
2pg0A03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.51	37.0	3.88e-01	74.7%	85.2%
8cdaB03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.50	36.0	3.65e-01	72.8%	92.5%
2c0uA03	1.20.140.10	Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3	0.50	36.0	3.62e-01	74.1%	79.3%

ECOD (33)

UID	F-ID	Classification	TM-score	Bits	E-value	Q cov	T cov
4946929	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.72	53.0	4.75e-01	75.9%	72.4%
4126386	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.69	51.0	4.65e-01	75.9%	71.0%
3373348	3684.1.1.2 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1	0.67	51.0	4.33e-01	78.4%	88.1%
3772490	5050.1.1.1 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr	0.66	49.0	3.97e-01	76.5%	58.3%
4019589	5050.1.1.8 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › FPN1	0.65	48.0	4.15e-01	76.5%	60.4%
3286869	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.64	48.0	4.49e-01	76.5%	73.8%
4944890	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.63	47.0	4.39e-01	76.5%	69.0%
3303386	5050.1.1.15 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nodulin-like	0.63	46.0	4.06e-01	76.5%	59.2%
4523195	192.11.1.0 ↗	alpha bundles › Long alpha-hairpin › C-terminal UvrC-binding domain of UvrB › C-terminal UvrC-binding domain of UvrB	0.62	48.0	4.39e-01	91.4%	61.9%
3175128	5050.1.1.9 ↗	alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1	0.62	46.0	3.94e-01	76.5%	58.8%
5060868	140.1.1.9 ↗	alpha bundles › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases › Anticodon_3	0.61	52.0	5.16e-01	91.4%	95.3%
3823764	3684.1.1.2 ↗	alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1	0.60	43.0	3.79e-01	74.7%	87.1%
3304305	603.1.1.0 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins	0.59	41.0	4.30e-01	70.4%	95.9%
3646445	3615.1.1.38 ↗	alpha bundles › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › Bacterial dynamin-like protein helical domain › ROH1-like	0.59	43.0	3.40e-01	74.7%	88.9%
3789277	1188.1.1.1 ↗	alpha bundles › ZIP zinc transporter › ZIP zinc transporter › ZIP zinc transporter › Zip	0.58	43.0	3.67e-01	76.5%	81.5%
4186195	1079.1.1.8 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › LysE	0.57	45.0	4.14e-01	84.0%	71.9%
3252931	633.6.1.1 ↗	alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA_dh_1	0.56	37.0	3.75e-01	88.3%	66.3%
3964313	1075.4.1.1 ↗	alpha bundles › Type II ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › Type I ABC exporter transmembrane domain fold › ABC_membrane	0.56	39.0	3.03e-01	70.4%	55.7%
3936980	174.1.1.1 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin	0.56	32.0	3.24e-01	77.8%	53.9%
5049102	192.29.1.0 ↗	alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding)	0.56	40.0	3.82e-01	72.8%	91.6%
4979030	150.1.1.0 ↗	alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin	0.55	35.0	3.74e-01	85.8%	71.0%
4950461	1079.1.1.5 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DsbD_2	0.55	43.0	4.00e-01	84.0%	75.2%
3976242	1079.1.1.8 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › LysE	0.55	43.0	3.99e-01	84.0%	72.4%
4977834	3745.1.1.1 ↗	alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex	0.55	49.0	3.79e-01	99.4%	80.3%
3379272	603.1.1.107 ↗	alpha bundles › STAT-like › t-snare proteins › t-snare proteins › Mlo	0.54	39.0	4.05e-01	79.0%	78.1%
3793986	604.7.1.7 ↗	alpha bundles › Spectrin repeat-like › Tubulin chaperone cofactor A › Tubulin chaperone cofactor A › Mitofilin	0.54	38.0	4.17e-01	77.2%	87.4%
5003109	1079.1.1.1 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA › DsbD	0.53	42.0	3.81e-01	84.0%	78.2%
3616792	633.6.1.8 ↗	alpha bundles › Bromodomain-like › Acyl-CoA dehydrogenase C-terminal domain-like › Acyl-CoA dehydrogenase C-terminal domain-like › ACOX_C_alpha1	0.53	37.0	3.50e-01	71.0%	82.0%
3820110	174.1.1.0 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain	0.52	37.0	3.92e-01	79.0%	83.6%
3625860	601.20.1.0 ↗	alpha bundles › Four-helical up-and-down bundle › Apolipophorin-III › Apolipophorin-III	0.51	35.0	3.41e-01	89.5%	61.7%
5037963	1079.1.1.0 ↗	alpha complex topology › Transmembrane reductase CcdA › Transmembrane reductase CcdA › Transmembrane reductase CcdA	0.51	41.0	3.61e-01	84.0%	75.7%
3901124	174.1.1.12 ↗	few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › BCLP	0.51	37.0	3.84e-01	78.4%	80.7%
3734606	604.5.1.8 ↗	alpha bundles › Spectrin repeat-like › PhoU-like (Pfam 01895) › PhoU-like (Pfam 01895) › ArAE_2	0.51	40.0	3.64e-01	83.3%	99.1%

D3 medium residues 900-996

PDB

Domain cluster: representative

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	99.6	2.60e-28	97.9%	24.6%

CATH (1)

Domain ID	Class ID	Classification	TM-score	Bits	E-value	Q cov	T cov
2daiA00	1.10.8.10	Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain	0.50	30.0	3.19e-01	74.2%	66.3%

D4 medium residues 997-1185

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_009137226__Human_alphaherpesvirus_2__10310__D928-1142

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	243.6	5.20e-72	100.0%	41.7%

D5 medium residues 1186-1335

PDB

Domain cluster: rep: transcriptional_regulator_ICP4__YP_002333545__Equid_alphaherpesvirus_9__55744__D1274-1352_1389-1419

Pfam (1)

Accession	Name	Score	E-value	Q cov	HMM cov
PF03585.20 best	Herpes_ICP4_C	119.9	1.70e-34	90.7%	32.0%