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transcriptional_regulator_ICP4
Euk-VirCercopithecine_alphaherpesvirus_2
transcriptional_regulator_ICP4__YP_164516__Cercopithecine_alphaherpesvirus_2__10317
Identity
- Accession:
- YP_164516 ↗
- Protein ID:
- transcriptional_regulator_ICP4
- Kingdom:
- euk
Quality
66.6
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Cercopithecine_alphaherpesvirus_2
TaxID: 10317
Cluster
View cluster (12 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 266-450
Domain cluster:
rep: hypothetical_protein__YP_009230205__Leporid_alphaherpesvirus_4__481315__D118-301
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03584.21 best | Herpes_ICP4_N | 258.5 | 4.20e-77 | 93.5% | 99.4% |
D2
high
residues 470-643
Domain cluster:
representative
CATH (36)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2pg0A03 | 1.20.140.10 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Butyryl-CoA Dehydrogenase, subunit A, domain 3 | 0.67 | 36.0 | 3.86e-01 | 75.9% | 60.4% |
| 4a4kA01 | 1.20.1500.20 | Mainly Alpha › Up-down Bundle › YheA-like fold › | 0.66 | 29.0 | 3.49e-01 | 80.5% | 60.2% |
| 1x8zB00 | 1.20.140.40 | Mainly Alpha › Up-down Bundle › Butyryl-CoA Dehydrogenase, subunit A; domain 3 › Invertase/pectin methylesterase inhibitor family protein | 0.63 | 30.0 | 3.28e-01 | 74.1% | 51.7% |
| 6kkiA01 | 1.20.1720.10 | Mainly Alpha › Up-down Bundle › Multidrug resistance protein D › Multidrug resistance protein D | 0.61 | 46.0 | 3.63e-01 | 81.0% | 38.0% |
| 3anwA01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.60 | 37.0 | 4.43e-01 | 97.1% | 92.9% |
| 4iu9B02 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.60 | 44.0 | 4.22e-01 | 75.9% | 77.8% |
| 5zbqA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.59 | 48.0 | 4.01e-01 | 85.1% | 82.3% |
| 3aeiA00 | 1.10.287.370 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.58 | 32.0 | 4.13e-01 | 84.5% | 96.8% |
| 4h3tA02 | 1.10.132.100 | Mainly Alpha › Orthogonal Bundle › Topoisomerase I; Chain A, domain 4 › | 0.58 | 30.0 | 3.28e-01 | 73.0% | 58.2% |
| 3v5uA02 | 1.20.1420.30 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › NCX, central ion-binding region | 0.57 | 51.0 | 4.77e-01 | 98.9% | 97.7% |
| 2jswA00 | 1.20.1410.10 | Mainly Alpha › Up-down Bundle › I/LWEQ domain › I/LWEQ domain | 0.57 | 42.0 | 4.08e-01 | 74.7% | 89.4% |
| 1jmwA00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.57 | 42.0 | 4.58e-01 | 86.2% | 91.1% |
| 2z73B01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.57 | 46.0 | 3.65e-01 | 84.5% | 76.3% |
| 2odvA01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 35.0 | 4.14e-01 | 100.0% | 92.9% |
| 5nl6B01 | 1.20.58.60 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.57 | 35.0 | 4.03e-01 | 80.5% | 86.0% |
| 2felA00 | 1.20.200.10 | Mainly Alpha › Up-down Bundle › Fumarase C; Chain A, domain 2 › Fumarase/aspartase (Central domain) | 0.56 | 40.0 | 3.24e-01 | 73.6% | 95.3% |
| 1wkbA03 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.55 | 38.0 | 4.40e-01 | 74.1% | 100.0% |
| 1f6fA00 | 1.20.1250.10 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › | 0.55 | 41.0 | 4.11e-01 | 96.0% | 73.2% |
| 4gc0A01 | 1.20.1250.20 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › MFS general substrate transporter like domains | 0.55 | 44.0 | 3.94e-01 | 84.5% | 96.0% |
| 1sj7C00 | 1.20.1420.10 | Mainly Alpha › Up-down Bundle › A middle domain of Talin 1 › Talin, central domain | 0.55 | 39.0 | 4.00e-01 | 71.3% | 92.2% |
| 3i01A01 | 1.20.1270.30 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › | 0.54 | 35.0 | 3.54e-01 | 73.0% | 64.4% |
| 3hhcC00 | 1.20.1250.60 | Mainly Alpha › Up-down Bundle › Growth Hormone; Chain: A; › Interferon lambda | 0.54 | 35.0 | 3.78e-01 | 82.2% | 75.5% |
| 7f16R01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.54 | 43.0 | 3.68e-01 | 84.5% | 80.9% |
| 1orjD00 | 1.20.120.340 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Flagellar protein FliS | 0.54 | 32.0 | 3.71e-01 | 78.7% | 81.6% |
| 7eq1R01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.54 | 43.0 | 3.68e-01 | 84.5% | 80.4% |
| 1w2yA00 | 1.10.4010.10 | Mainly Alpha › Orthogonal Bundle › all-alpha NTP pyrophosphatase fold › Type II deoxyuridine triphosphatase | 0.54 | 43.0 | 3.92e-01 | 83.9% | 64.6% |
| 4zudA01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.53 | 43.0 | 3.79e-01 | 84.5% | 87.5% |
| 1io1A01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.53 | 39.0 | 4.00e-01 | 83.9% | 78.1% |
| 3tp3A02 | 1.10.357.10 | Mainly Alpha › Orthogonal Bundle › Tetracycline Repressor; domain 2 › Tetracycline Repressor, domain 2 | 0.53 | 41.0 | 4.41e-01 | 97.7% | 95.9% |
| 7cj3A01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.52 | 41.0 | 3.61e-01 | 83.9% | 74.8% |
| 2f2gA00 | 1.20.910.10 | Mainly Alpha › Up-down Bundle › Heme Oxygenase; Chain A › Heme oxygenase-like | 0.51 | 41.0 | 3.83e-01 | 83.9% | 77.7% |
| 1fftC00 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.51 | 40.0 | 3.97e-01 | 83.9% | 77.3% |
| 1qoyA00 | 1.20.1170.10 | Mainly Alpha › Up-down Bundle › Hemolysin E; Chain: A; › | 0.51 | 37.0 | 3.14e-01 | 76.4% | 96.0% |
| 3pwxA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.51 | 38.0 | 3.74e-01 | 84.5% | 72.8% |
| 5gl7A01 | 1.10.730.10 | Mainly Alpha › Orthogonal Bundle › Isoleucyl-tRNA Synthetase; Domain 1 › Isoleucyl-tRNA Synthetase; Domain 1 | 0.51 | 41.0 | 4.19e-01 | 85.1% | 98.2% |
| 2e9xD01 | 1.20.58.1030 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.50 | 37.0 | 4.13e-01 | 99.4% | 95.6% |
ECOD (32)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3304974 | 3684.1.1.2 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1 | 0.67 | 52.0 | 4.40e-01 | 80.5% | 90.4% |
| 3788011 | 5050.1.1.15 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Nodulin-like | 0.63 | 46.0 | 4.36e-01 | 77.0% | 70.2% |
| 3480464 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.62 | 44.0 | 4.05e-01 | 73.6% | 71.1% |
| 3836003 | 3684.1.1.2 ↗ | alpha complex topology › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › PSPTO4464 C-terminal domain-like › BPS1 | 0.62 | 48.0 | 4.54e-01 | 80.5% | 91.2% |
| 3796800 | 633.21.1.0 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 | 0.61 | 32.0 | 3.64e-01 | 79.9% | 64.6% |
| 4083830 | 5050.1.1.23 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › CLN3 | 0.61 | 48.0 | 4.56e-01 | 81.6% | 83.5% |
| 4993740 | 633.21.1.48 ↗ | alpha bundles › Bromodomain-like › Uncharacterized protein PA2107 › Uncharacterized protein PA2107 › DUF4418 | 0.60 | 32.0 | 3.60e-01 | 100.0% | 64.4% |
| 4590703 | 5050.1.1.54 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Mntp | 0.60 | 46.0 | 4.42e-01 | 79.3% | 97.4% |
| 3232959 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 44.0 | 4.24e-01 | 78.7% | 72.0% |
| 5010796 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.58 | 42.0 | 4.23e-01 | 80.5% | 72.2% |
| 5079257 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.58 | 42.0 | 4.06e-01 | 73.6% | 73.3% |
| 3688792 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.58 | 45.0 | 4.03e-01 | 82.2% | 61.2% |
| 3297435 | 174.1.1.15 ↗ | few secondary structure elements › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › Tetraspanin transmembrane domain › AWPM-19 | 0.57 | 33.0 | 3.51e-01 | 78.2% | 62.6% |
| 3885478 | 150.1.1.100 ↗ | alpha bundles › Ferritin/Heme oxygenase/4-helical cytokines › Ferritin/Heme oxygenase › Ferritin › TMD0_ABC | 0.57 | 33.0 | 3.17e-01 | 78.2% | 49.2% |
| 3804970 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.57 | 42.0 | 3.83e-01 | 76.4% | 64.2% |
| 4567535 | 1203.1.2.0 ↗ | alpha bundles › Shroom domain 2 › Shroom domain 2 › Human SD2 | 0.57 | 32.0 | 2.73e-01 | 85.1% | 33.3% |
| 3539123 | 5050.1.1.6 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › OATP | 0.57 | 45.0 | 3.90e-01 | 83.9% | 68.0% |
| 5024947 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.57 | 43.0 | 4.31e-01 | 79.9% | 76.1% |
| 4000229 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.57 | 42.0 | 4.06e-01 | 82.8% | 67.0% |
| 1312286 | 5050.1.1.2 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › PTR2 | 0.56 | 43.0 | 3.90e-01 | 80.5% | 60.9% |
| 4948472 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.56 | 40.0 | 3.39e-01 | 74.1% | 67.8% |
| 4025655 | 192.2.1.2 ↗ | alpha bundles › Long alpha-hairpin › Prefoldin › Prefoldin › Prefoldin | 0.56 | 30.0 | 3.99e-01 | 84.5% | 96.8% |
| 3633559 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.56 | 42.0 | 3.84e-01 | 77.0% | 65.8% |
| 3506731 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.55 | 42.0 | 4.11e-01 | 84.5% | 70.8% |
| 5009659 | 5050.1.1.9 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › MFS_1 | 0.55 | 42.0 | 4.04e-01 | 82.8% | 69.7% |
| 3221730 | 5059.1.1.11 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › TMEM144 | 0.55 | 45.0 | 3.74e-01 | 86.2% | 96.3% |
| 3935598 | 5050.1.1.1 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Sugar_tr | 0.54 | 43.0 | 4.01e-01 | 82.8% | 90.5% |
| 4153900 | 5069.1.1.6 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes › COX15-CtaA | 0.54 | 43.0 | 3.42e-01 | 84.5% | 48.5% |
| 3972623 | 5059.1.1.1 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › EamA | 0.53 | 38.0 | 3.28e-01 | 73.6% | 69.8% |
| 3237808 | 5059.1.1.11 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › TMEM144 | 0.53 | 43.0 | 3.63e-01 | 85.6% | 97.7% |
| 3628945 | 5050.1.1.0 ↗ | alpha complex topology › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter › Major facilitator superfamily (MFS) general substrate transporter | 0.53 | 43.0 | 4.09e-01 | 85.1% | 90.7% |
| 3430186 | 5059.1.1.3 ↗ | alpha bundles › Drug/Metabolite transporter › Drug/Metabolite transporter › Drug/Metabolite transporter › TPT | 0.52 | 36.0 | 3.54e-01 | 81.6% | 63.6% |
D3
medium
residues 795-990_1061-1123
Domain cluster:
rep: transcriptional_regulator_ICP4__YP_009137226__Human_alphaherpesvirus_2__10310__D928-1142
Pfam (2)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03585.20 best | Herpes_ICP4_C | 316.0 | 5.50e-94 | 76.4% | 44.6% |
| PF03585.20 | Herpes_ICP4_C | 32.2 | 7.00e-08 | 24.7% | 15.8% |
D4
medium
residues 991-1060
Domain cluster:
rep: transcriptional_regulator_ICP4__NP_040184__Human_alphaherpesvirus_3__10335__D1029-1108
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF03585.20 best | Herpes_ICP4_C | 95.3 | 5.10e-27 | 100.0% | 15.8% |