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vif_protein
Euk-VirHuman_immunodeficiency_virus_2
vif_protein__NP_056839__Human_immunodeficiency_virus_2__11709
Identity
- Accession:
- NP_056839 ↗
- Protein ID:
- vif_protein
- Kingdom:
- euk
Quality
58.8
mean pLDDT
Taxonomy
Pararnavirae›
Artverviricota›
Revtraviricetes›
Ortervirales›
Retroviridae›
Lentivirus›
Human_immunodeficiency_virus_2
TaxID: 11709
Cluster
View cluster (3 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 18-101
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00559.24 best | Vif | 53.8 | 3.30e-14 | 100.0% | 43.2% |
CATH (44)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2q2bA00 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.71 | 50.0 | 4.20e-01 | 73.8% | 75.2% |
| 1y7uA00 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.71 | 51.0 | 4.06e-01 | 76.2% | 90.2% |
| 3cqnB00 | 2.40.128.20 | Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain | 0.70 | 51.0 | 4.07e-01 | 76.2% | 45.3% |
| 2gvhC01 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.70 | 49.0 | 4.12e-01 | 72.6% | 83.1% |
| 2fwvA00 | 2.40.128.20 | Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain | 0.69 | 58.0 | 4.40e-01 | 90.5% | 53.7% |
| 5da9A01 | 3.40.50.300 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › P-loop containing nucleotide triphosphate hydrolases | 0.69 | 52.0 | 3.40e-01 | 79.8% | 37.8% |
| 1qhlA00 | 3.40.1140.10 | Alpha Beta › 3-Layer(aba) Sandwich › N-terminal domain of mukB › | 0.67 | 51.0 | 3.86e-01 | 82.1% | 74.9% |
| 3n8bA00 | 3.10.450.700 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.66 | 47.0 | 4.91e-01 | 85.7% | 81.3% |
| 2gvhB02 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.65 | 51.0 | 4.50e-01 | 82.1% | 93.2% |
| 3cygA01 | 3.30.565.40 | Alpha Beta › 2-Layer Sandwich › Heat Shock Protein 90 › Fervidobacterium nodosum Rt17-B1 like | 0.65 | 47.0 | 4.20e-01 | 76.2% | 100.0% |
| 4boeA00 | 2.40.128.20 | Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain | 0.64 | 46.0 | 3.81e-01 | 76.2% | 48.1% |
| 4k02A00 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.62 | 53.0 | 4.61e-01 | 94.0% | 91.3% |
| 3e1eC00 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.61 | 53.0 | 4.40e-01 | 94.0% | 80.1% |
| 1lshA03 | 2.20.50.20 | Mainly Beta › Single Sheet › Outer Surface Protein A; domain 2 › Lipovitellin. Chain A, domain 3 | 0.60 | 44.0 | 4.20e-01 | 77.4% | 83.7% |
| 3djwA00 | 3.30.160.300 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.60 | 50.0 | 4.85e-01 | 90.5% | 90.5% |
| 1jmxA02 | 2.40.128.120 | Mainly Beta › Beta Barrel › Lipocalin › Quinohemoprotein amine dehydrogenase alpha subunit, domain 2 | 0.59 | 44.0 | 4.03e-01 | 78.6% | 61.5% |
| 5tgnA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.59 | 41.0 | 3.76e-01 | 89.3% | 55.0% |
| 2f86B00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.59 | 44.0 | 3.92e-01 | 82.1% | 99.2% |
| 2h36X00 | 3.30.160.300 | Alpha Beta › 2-Layer Sandwich › Double Stranded RNA Binding Domain › | 0.59 | 49.0 | 4.52e-01 | 90.5% | 80.6% |
| 5evhA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.58 | 41.0 | 3.69e-01 | 90.5% | 51.2% |
| 1wzvA00 | 3.10.110.10 | Alpha Beta › Roll › Ubiquitin Conjugating Enzyme › Ubiquitin Conjugating Enzyme | 0.58 | 39.0 | 3.31e-01 | 70.2% | 86.0% |
| 3ia8A00 | 2.40.128.20 | Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain | 0.58 | 44.0 | 3.60e-01 | 90.5% | 42.6% |
| 3f14A00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.58 | 42.0 | 3.84e-01 | 86.9% | 58.0% |
| 2ckfB00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.57 | 43.0 | 3.52e-01 | 82.1% | 90.0% |
| 1c8uA01 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.57 | 45.0 | 3.69e-01 | 85.7% | 77.6% |
| 4r1kB00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.56 | 49.0 | 4.25e-01 | 98.8% | 86.8% |
| 3gwrB00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.56 | 41.0 | 3.58e-01 | 76.2% | 92.1% |
| 1x7dB01 | 3.30.1780.10 | Alpha Beta › 2-Layer Sandwich › ornithine cyclodeaminase, domain 1 › ornithine cyclodeaminase, domain 1 | 0.56 | 49.0 | 3.97e-01 | 100.0% | 53.3% |
| 4ztkA00 | 3.40.710.10 | Alpha Beta › 3-Layer(aba) Sandwich › Beta-lactamase › DD-peptidase/beta-lactamase superfamily | 0.56 | 48.0 | 3.44e-01 | 97.6% | 94.8% |
| 1f49A05 | 2.70.98.10 | Mainly Beta › Distorted Sandwich › Beta-galactosidase; Chain A, domain 5 › | 0.56 | 49.0 | 3.40e-01 | 98.8% | 90.3% |
| 3doaA01 | 2.30.310.10 | Mainly Beta › Roll › ibrinogen binding protein from staphylococcus aureus fold › ibrinogen binding protein from staphylococcus aureus domain | 0.56 | 50.0 | 4.09e-01 | 100.0% | 68.6% |
| 1ar0A00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.55 | 41.0 | 3.69e-01 | 81.0% | 93.6% |
| 3gp6A00 | 2.40.160.20 | Mainly Beta › Beta Barrel › Porin › | 0.55 | 46.0 | 3.85e-01 | 96.4% | 85.2% |
| 3g8yA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.55 | 42.0 | 2.75e-01 | 83.3% | 43.5% |
| 1yliB00 | 3.10.129.10 | Alpha Beta › Roll › Thiol Ester Dehydrase; Chain A › Hotdog Thioesterase | 0.54 | 45.0 | 3.80e-01 | 92.9% | 77.7% |
| 4bboA00 | 2.40.128.30 | Mainly Beta › Beta Barrel › Lipocalin › Avidin-like | 0.54 | 47.0 | 4.31e-01 | 100.0% | 87.6% |
| 3a9gA00 | 2.120.10.30 | Mainly Beta › 6 Propeller › Neuraminidase › TolB, C-terminal domain | 0.54 | 44.0 | 2.96e-01 | 90.5% | 30.5% |
| 2g8sB00 | 2.120.10.30 | Mainly Beta › 6 Propeller › Neuraminidase › TolB, C-terminal domain | 0.52 | 45.0 | 3.00e-01 | 96.4% | 38.3% |
| 3blzA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.52 | 42.0 | 3.73e-01 | 90.5% | 88.7% |
| 3ecfA00 | 3.10.450.50 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › | 0.52 | 37.0 | 3.32e-01 | 77.4% | 82.0% |
| 1l7aA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.51 | 40.0 | 2.76e-01 | 86.9% | 47.8% |
| 4fczA00 | 3.10.450.710 | Alpha Beta › Roll › Nuclear Transport Factor 2; Chain: A, › Tgt2/MlaC | 0.51 | 43.0 | 3.45e-01 | 98.8% | 78.1% |
| 3fcyA00 | 3.40.50.1820 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › Alpha/Beta hydrolase fold, catalytic domain | 0.50 | 41.0 | 2.84e-01 | 91.7% | 48.3% |
| 1aqbA00 | 2.40.128.20 | Mainly Beta › Beta Barrel › Lipocalin › Calycin beta-barrel core domain | 0.50 | 43.0 | 3.49e-01 | 100.0% | 85.7% |
ECOD (48)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 3295575 | 284.1.3.2 ↗ | a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain › OSR1_C | 0.73 | 50.0 | 4.74e-01 | 76.2% | 60.0% |
| 3229268 | 3369.1.1.0 ↗ | beta meanders › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 › lysosome-associated membrane protein LAMP-3 | 0.67 | 61.0 | 4.71e-01 | 98.8% | 72.6% |
| 3227179 | 243.1.1.85 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › PF26531 | 0.65 | 50.0 | 4.47e-01 | 83.3% | 94.2% |
| 5062234 | 331.9.1.0 ↗ | a+b two layers › TBP-like › Subdomain of clathrin and coatomer appendage domain › Subdomain of clathrin and coatomer appendage domain | 0.64 | 50.0 | 4.42e-01 | 100.0% | 58.3% |
| 3225806 | 11.1.1.0 ↗ | beta sandwiches › Immunoglobulin-like beta-sandwich › Immunoglobulin-related › Immunoglobulin/Fibronectin type III/E set domains/PapD-like | 0.64 | 43.0 | 3.86e-01 | 70.2% | 74.2% |
| 4514020 | 2004.1.1.199 ↗ | a/b three-layered sandwiches › P-loop domains-like › P-loop domains-related › P-loop containing nucleoside triphosphate hydrolases › AAA_23,SbcC_Walker_B | 0.63 | 51.0 | 3.09e-01 | 86.9% | 22.5% |
| 3470957 | 109.4.1.19 ↗ | alpha superhelices › Repetitive alpha hairpins › ARM repeat › ARM repeat › Vitellogenin_N | 0.63 | 49.0 | 3.18e-01 | 83.3% | 43.2% |
| 4088781 | 12.3.1.6 ↗ | beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › Bgal_small_N | 0.62 | 45.0 | 3.51e-01 | 76.2% | 65.0% |
| 3217076 | 243.1.1.75 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › PF26530 | 0.62 | 45.0 | 4.03e-01 | 76.2% | 100.0% |
| 5040084 | 283.2.1.0 ↗ | a+b duplicates or obligate multimers › Creatinase/aminopeptidase-like › gpW/gp25-like › gpW/gp25-like | 0.61 | 51.0 | 4.55e-01 | 92.9% | 87.5% |
| 3209799 | 222.1.1.17 ↗ | a+b two layers › Thioesterase/thiol ester dehydrase-isomerase-like › Thioesterase/thiol ester dehydrase-isomerase › Thioesterase/thiol ester dehydrase-isomerase › PKS_DH_N | 0.60 | 50.0 | 4.20e-01 | 89.3% | 87.1% |
| 3280323 | 243.1.1.7 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › MecA_N | 0.60 | 43.0 | 4.05e-01 | 76.2% | 95.2% |
| 3818341 | 331.9.1.4 ↗ | a+b two layers › TBP-like › Subdomain of clathrin and coatomer appendage domain › Subdomain of clathrin and coatomer appendage domain › Coatomer_g_Cpla | 0.59 | 46.0 | 4.73e-01 | 98.8% | 88.5% |
| 3277627 | 243.1.1.0 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like | 0.59 | 43.0 | 3.93e-01 | 77.4% | 91.3% |
| 4940923 | 243.3.1.0 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin | 0.59 | 44.0 | 4.56e-01 | 96.4% | 83.7% |
| 4208434 | 12.3.1.24 ↗ | beta sandwiches › Glycosyl hydrolase domain-like › supersandwich › supersandwich › YidC_periplas | 0.59 | 54.0 | 3.65e-01 | 100.0% | 75.3% |
| 4525648 | 222.1.1.17 ↗ | a+b two layers › Thioesterase/thiol ester dehydrase-isomerase-like › Thioesterase/thiol ester dehydrase-isomerase › Thioesterase/thiol ester dehydrase-isomerase › PKS_DH_N | 0.59 | 51.0 | 4.28e-01 | 94.0% | 91.4% |
| 164598 | 331.15.1.1 ↗ | a+b two layers › TBP-like › Anti-CRISPR protein AcrID1 › Anti-CRISPR protein AcrID1 › DUF1374 | 0.59 | 49.0 | 4.52e-01 | 90.5% | 80.6% |
| 3940149 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.58 | 41.0 | 4.06e-01 | 95.2% | 68.9% |
| 3401376 | 5.1.4.8 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › CNH | 0.58 | 46.0 | 3.05e-01 | 85.7% | 24.6% |
| 4951451 | 881.1.1.0 ↗ | a+b three layers › Mog1p/PsbP-like › Mog1p/PsbP-like › Mog1p/PsbP-like | 0.58 | 51.0 | 4.28e-01 | 97.6% | 65.5% |
| 3807410 | 331.3.1.3 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like › START | 0.58 | 51.0 | 3.67e-01 | 97.6% | 73.3% |
| 3279738 | 3692.1.1.1 ↗ | a+b two layers › Ornithine cyclodeaminase-like enzymes dimerization domain › Ornithine cyclodeaminase-like enzymes dimerization domain › Ornithine cyclodeaminase-like enzymes dimerization domain › OCD_Mu_crystall | 0.58 | 49.0 | 4.15e-01 | 100.0% | 69.7% |
| 4936938 | 331.3.1.0 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like | 0.57 | 52.0 | 4.31e-01 | 98.8% | 73.8% |
| 3676028 | 331.3.1.0 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like | 0.57 | 51.0 | 3.61e-01 | 97.6% | 73.2% |
| 3818651 | 331.3.1.3 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like › START | 0.57 | 51.0 | 3.56e-01 | 97.6% | 67.2% |
| 3744021 | 331.9.1.4 ↗ | a+b two layers › TBP-like › Subdomain of clathrin and coatomer appendage domain › Subdomain of clathrin and coatomer appendage domain › Coatomer_g_Cpla | 0.57 | 44.0 | 4.06e-01 | 98.8% | 63.6% |
| 4196609 | 3692.1.1.0 ↗ | a+b two layers › Ornithine cyclodeaminase-like enzymes dimerization domain › Ornithine cyclodeaminase-like enzymes dimerization domain › Ornithine cyclodeaminase-like enzymes dimerization domain | 0.57 | 51.0 | 4.54e-01 | 100.0% | 69.2% |
| 3698492 | 216.1.1.0 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like | 0.57 | 49.0 | 4.38e-01 | 98.8% | 67.2% |
| 3339570 | 331.3.1.3 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like › START | 0.57 | 51.0 | 3.58e-01 | 97.6% | 71.2% |
| 4348187 | 243.3.1.0 ↗ | a+b two layers › Cystatin-like › Cystatin/monellin › Cystatin/monellin | 0.57 | 42.0 | 4.20e-01 | 95.2% | 77.6% |
| 5033737 | 71.1.1.0 ↗ | beta meanders › Lipoprotein localization factors LolAB › Lipoprotein localization factors LolAB › Lipoprotein localization factors LolAB | 0.57 | 45.0 | 3.55e-01 | 100.0% | 39.4% |
| 3345243 | 331.3.1.3 ↗ | a+b two layers › TBP-like › Bet v1-like › Bet v1-like › START | 0.56 | 49.0 | 3.56e-01 | 97.6% | 74.6% |
| 3938215 | 243.1.1.28 ↗ | a+b two layers › Cystatin-like › NTF2-like › NTF2-like › DUF4440 | 0.56 | 47.0 | 4.12e-01 | 100.0% | 95.0% |
| 3711273 | 331.9.1.0 ↗ | a+b two layers › TBP-like › Subdomain of clathrin and coatomer appendage domain › Subdomain of clathrin and coatomer appendage domain | 0.56 | 43.0 | 3.98e-01 | 100.0% | 64.0% |
| 3188943 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.55 | 45.0 | 2.92e-01 | 90.5% | 30.9% |
| 3439646 | 284.1.3.2 ↗ | a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain › OSR1_C | 0.55 | 46.0 | 4.31e-01 | 97.6% | 73.3% |
| 3946213 | 295.1.1.0 ↗ | a+b two layers › ssDNA-binding transcriptional regulator domain-like › ssDNA-binding transcriptional regulator domain › ssDNA-binding transcriptional regulator domain | 0.55 | 46.0 | 3.83e-01 | 91.7% | 56.7% |
| 4024578 | 216.1.1.4 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like › RWD | 0.55 | 47.0 | 3.95e-01 | 98.8% | 53.5% |
| 3392175 | 5.1.3.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed | 0.55 | 45.0 | 3.23e-01 | 92.9% | 57.0% |
| 3987311 | 7579.1.1.27 ↗ | a/b three-layered sandwiches › alpha/beta-Hydrolases › alpha/beta-Hydrolases › alpha/beta-Hydrolases › AXE1 | 0.55 | 45.0 | 3.07e-01 | 91.7% | 48.9% |
| 3653398 | 331.9.1.10 ↗ | a+b two layers › TBP-like › Subdomain of clathrin and coatomer appendage domain › Subdomain of clathrin and coatomer appendage domain › PF28631 | 0.54 | 47.0 | 3.92e-01 | 100.0% | 67.7% |
| 4888729 | 243.19.1.0 ↗ | a+b two layers › Cystatin-like › Phi ETA orf 56-like protein C-terminal domains › Phi ETA orf 56-like protein C-terminal domains | 0.53 | 43.0 | 4.06e-01 | 90.5% | 81.1% |
| 3708351 | 5.1.4.1 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed › WD40 | 0.53 | 44.0 | 3.05e-01 | 94.0% | 90.5% |
| 399504 | 5.1.3.22 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 6-bladed › GSDH | 0.53 | 44.0 | 2.99e-01 | 94.0% | 30.8% |
| 3413325 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.52 | 45.0 | 2.96e-01 | 97.6% | 30.8% |
| 3592006 | 216.1.1.4 ↗ | a+b two layers › UBC-like › UBC-like › UBC-like › RWD | 0.52 | 46.0 | 3.82e-01 | 97.6% | 62.1% |
| 3719349 | 5.1.4.0 ↗ | beta duplicates or obligate multimers › beta-propeller-like › beta-propeller › 7-bladed | 0.52 | 43.0 | 2.75e-01 | 91.7% | 35.1% |
D2
medium
residues 102-161_205-215