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virion_protein_US10
Euk-VirHuman_alphaherpesvirus_2
virion_protein_US10__YP_009137223__Human_alphaherpesvirus_2__10310
Identity
- Accession:
- YP_009137223 ↗
- Protein ID:
- virion_protein_US10
- Kingdom:
- euk
Quality
58.3
mean pLDDT
Taxonomy
Heunggongvirae›
Peploviricota›
Herviviricetes›
Herpesvirales›
Orthoherpesviridae›
Simplexvirus›
Human_alphaherpesvirus_2
TaxID: 10310
Cluster
View cluster (6 members)3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 160-283
Domain cluster:
rep: virion_protein_US10__NP_040186__Human_alphaherpesvirus_3__10335__D26-166
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF02053.21 best | Gene66 | 58.8 | 8.90e-16 | 100.0% | 57.9% |
CATH (29)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2p7vA00 | 1.20.120.1370 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Regulator of RNA polymerase sigma(70) subunit, domain 4 | 0.77 | 63.0 | 5.88e-01 | 86.3% | 92.7% |
| 4hyjA00 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.75 | 62.0 | 4.94e-01 | 87.1% | 90.3% |
| 4w8pA02 | 1.20.120.230 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Alpha-catenin/vinculin-like | 0.75 | 56.0 | 5.60e-01 | 79.0% | 93.1% |
| 1y4cA03 | 1.20.120.660 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › IL-4 antagonist (De novo design) like domain | 0.74 | 56.0 | 5.86e-01 | 79.0% | 89.4% |
| 1tqgA00 | 1.20.120.160 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › HPT domain | 0.73 | 54.0 | 5.81e-01 | 79.8% | 91.4% |
| 2yevA03 | 1.20.120.80 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Cytochrome c oxidase, subunit III, four-helix bundle | 0.72 | 55.0 | 4.82e-01 | 79.8% | 69.0% |
| 3zsuA00 | 1.20.120.290 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Oxygen-evolving enhancer protein 3 (PsbQ), four-helix up-down bundle | 0.72 | 54.0 | 5.57e-01 | 79.0% | 90.7% |
| 1ylmA00 | 1.20.120.580 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › bsu32300-like | 0.71 | 54.0 | 5.14e-01 | 79.0% | 94.4% |
| 1dk8A02 | 1.10.167.10 | Mainly Alpha › Orthogonal Bundle › Regulator of G-protein Signalling 4; domain 2 › Regulator of G-protein Signalling 4, domain 2 | 0.70 | 47.0 | 5.49e-01 | 78.2% | 100.0% |
| 4nqfA00 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.69 | 51.0 | 4.89e-01 | 77.4% | 86.2% |
| 2yfaB01 | 1.20.1440.210 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › | 0.68 | 51.0 | 5.26e-01 | 79.8% | 92.4% |
| 5ziyA01 | 1.20.1330.10 | Mainly Alpha › Up-down Bundle › f41 fragment of flagellin, N-terminal domain › f41 fragment of flagellin, N-terminal domain | 0.68 | 51.0 | 4.42e-01 | 79.8% | 74.2% |
| 1b68A00 | 1.20.120.20 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Apolipoprotein | 0.67 | 50.0 | 4.83e-01 | 78.2% | 98.6% |
| 2kmfA01 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.63 | 48.0 | 5.14e-01 | 79.0% | 96.1% |
| 2pbeA02 | 1.20.120.330 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Nucleotidyltransferases domain 2 | 0.63 | 50.0 | 4.98e-01 | 83.9% | 88.1% |
| 1jmwA00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.62 | 47.0 | 4.47e-01 | 79.8% | 78.8% |
| 5x56B00 | 1.20.58.810 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Photosystem II Pbs27 | 0.61 | 46.0 | 4.88e-01 | 79.8% | 94.3% |
| 3t9oB00 | 1.20.120.30 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Aspartate receptor, ligand-binding domain | 0.61 | 46.0 | 4.67e-01 | 79.8% | 95.8% |
| 1e7pC00 | 1.20.1300.10 | Mainly Alpha › Up-down Bundle › 3 helical TM bundles of succinate and fumarate reductases › Fumarate reductase/succinate dehydrogenase, transmembrane subunit | 0.60 | 49.0 | 3.90e-01 | 88.7% | 79.9% |
| 4p3gD00 | 1.10.3450.40 | Mainly Alpha › Orthogonal Bundle › Hyaluronidase domain-like › Signal recognition particle, SRP68 subunit, RNA-binding domain | 0.57 | 51.0 | 4.41e-01 | 100.0% | 87.2% |
| 1j1jA01 | 1.20.58.190 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 1 | 0.55 | 40.0 | 3.94e-01 | 92.7% | 69.7% |
| 2no4A02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.55 | 30.0 | 3.73e-01 | 92.7% | 88.0% |
| 2a0uB01 | 1.20.120.420 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › translation initiation factor eif-2b, domain 1 | 0.54 | 46.0 | 4.28e-01 | 92.7% | 81.9% |
| 1b4cA00 | 1.10.238.10 | Mainly Alpha › Orthogonal Bundle › Recoverin; domain 1 › EF-hand | 0.53 | 37.0 | 4.18e-01 | 87.1% | 96.7% |
| 3f4mA00 | 1.20.1440.160 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Tumor necrosis factor alpha-induced protein 8-like | 0.53 | 43.0 | 4.03e-01 | 87.9% | 97.4% |
| 7eq1R01 | 1.20.1070.10 | Mainly Alpha › Up-down Bundle › Rhopdopsin 7-helix transmembrane proteins › Rhodopsin 7-helix transmembrane proteins | 0.51 | 43.0 | 3.41e-01 | 96.0% | 78.9% |
| 2mx8A01 | 1.10.274.70 | Mainly Alpha › Orthogonal Bundle › Enzyme I; Chain A, domain 2 › Spidroin, N-terminal domain | 0.50 | 39.0 | 4.08e-01 | 100.0% | 91.2% |
| 4wr4A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.50 | 37.0 | 3.97e-01 | 77.4% | 90.5% |
| 3kmiA00 | 1.20.120.940 | Mainly Alpha › Up-down Bundle › Four Helix Bundle (Hemerythrin (Met), subunit A) › Putative aromatic acid exporter, C-terminal domain | 0.50 | 42.0 | 3.83e-01 | 93.5% | 93.0% |
ECOD (28)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 4020563 | 601.16.1.3 ↗ | alpha bundles › Four-helical up-and-down bundle › FAT domain of focal adhesion kinase › FAT domain of focal adhesion kinase › GIT1_C | 0.79 | 61.0 | 5.99e-01 | 79.8% | 87.7% |
| 4963252 | 5069.1.1.0 ↗ | alpha bundles › Transmembrane heme-binding four-helical bundle › Transmembrane heme-binding four-helical bundle › Transmembrane di-heme cytochromes | 0.76 | 57.0 | 4.77e-01 | 79.0% | 75.2% |
| 3790952 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.75 | 57.0 | 5.46e-01 | 79.8% | 82.8% |
| 3217935 | 601.2.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes | 0.74 | 56.0 | 5.73e-01 | 79.8% | 95.8% |
| 1178517 | 5039.1.1.1 ↗ | alpha bundles › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › Cytochrome c oxidase subunit III-like › COX3 | 0.72 | 55.0 | 4.39e-01 | 79.8% | 52.2% |
| 5002025 | 601.33.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › CHAD domain › CHAD domain › CHAD | 0.71 | 53.0 | 4.93e-01 | 78.2% | 94.2% |
| 4949044 | 601.3.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt | 0.70 | 57.0 | 5.96e-01 | 92.7% | 95.6% |
| 4972788 | 601.2.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Cytochromes › Cytochromes | 0.69 | 51.0 | 5.33e-01 | 79.0% | 85.5% |
| 3293442 | 5082.1.1.1 ↗ | alpha bundles › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation efflux protein transmembrane domain-like › Cation_efflux | 0.67 | 48.0 | 3.90e-01 | 73.4% | 87.1% |
| 3228529 | 192.29.1.0 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) | 0.67 | 50.0 | 4.72e-01 | 79.0% | 82.0% |
| 184809 | 601.3.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt | 0.67 | 57.0 | 5.41e-01 | 92.7% | 78.6% |
| 3969575 | 601.3.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt | 0.66 | 56.0 | 5.51e-01 | 92.7% | 86.7% |
| 4995268 | 601.3.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt | 0.65 | 55.0 | 5.42e-01 | 92.7% | 85.4% |
| 4964703 | 601.3.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt | 0.65 | 55.0 | 5.48e-01 | 92.7% | 86.9% |
| 3386367 | 601.3.1.1 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain › Hpt | 0.65 | 56.0 | 5.47e-01 | 92.7% | 85.2% |
| 3967073 | 601.3.1.0 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine-containing phosphotransfer domain, HPT domain › Histidine-containing phosphotransfer domain, HPT domain | 0.63 | 53.0 | 5.38e-01 | 91.9% | 93.3% |
| 3784102 | 192.29.1.29 ↗ | alpha bundles › Long alpha-hairpin › bMERB domain (bivalent Mical/EHBP Rab binding) › bMERB domain (bivalent Mical/EHBP Rab binding) › DUF4112 | 0.61 | 49.0 | 4.66e-01 | 86.3% | 92.4% |
| 4034504 | 601.4.1.47 ↗ | alpha bundles › Four-helical up-and-down bundle › Histidine kinase associated sensor domains › Histidine kinase associated sensor domains › MspA_staph | 0.59 | 45.0 | 4.78e-01 | 79.8% | 100.0% |
| 3302202 | 3745.1.1.1 ↗ | alpha bundles › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Sodium/Calcium exchanger › Na_Ca_ex | 0.55 | 47.0 | 3.44e-01 | 92.7% | 91.2% |
| 4027991 | 4984.1.1.0 ↗ | alpha bundles › Duffy-binding-like domain, C-terminal subdomain › Duffy-binding-like domain, C-terminal subdomain › Duffy-binding-like domain, C-terminal subdomain | 0.55 | 38.0 | 4.31e-01 | 91.9% | 92.6% |
| 3888273 | 627.1.1.2 ↗ | alpha complex topology › VPS9 domain › VPS9 domain › VPS9 domain › DUF5601 | 0.54 | 36.0 | 4.05e-01 | 95.2% | 88.4% |
| 3454431 | 108.1.1.129 ↗ | alpha arrays › EF-hand › EF-hand-related › EF-hand › DUF7874 | 0.54 | 34.0 | 3.90e-01 | 91.9% | 87.8% |
| 3704726 | 310.2.1.0 ↗ | a+b two layers › RRF/tRNA synthetase additional domain-like › Ribosome recycling factor, RRF › Ribosome recycling factor, RRF | 0.54 | 46.0 | 4.23e-01 | 94.4% | 81.8% |
| 4936001 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.52 | 38.0 | 3.96e-01 | 95.2% | 81.7% |
| 3501219 | 181.1.1.0 ↗ | alpha bundles › Domain of the SRP/SRP receptor G proteins-like › Domain of the SRP/SRP receptor G-proteins › Domain of the SRP/SRP receptor G-proteins | 0.51 | 39.0 | 4.14e-01 | 83.9% | 95.2% |
| 5008677 | 3896.1.2.0 ↗ | alpha duplicates or obligate multimers › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-DAG synthetase-related › Intramembrane CDP-archaeol synthase | 0.51 | 35.0 | 3.38e-01 | 71.0% | 90.0% |
| 5057941 | 1075.5.1.0 ↗ | alpha bundles › Type II ABC exporter transmembrane domain fold › Multidrug and toxic compound extrusion (MATE) transporter › Multidrug and toxic compound extrusion (MATE) transporter | 0.50 | 42.0 | 3.82e-01 | 92.7% | 65.9% |
| 3924415 | 5001.1.1.44 ↗ | alpha bundles › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › Family A G protein-coupled receptor-like › 7TM_GPCR_Srv | 0.50 | 43.0 | 3.35e-01 | 98.4% | 77.4% |