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vpr_protein
Euk-VirHuman_immunodeficiency_virus_2
vpr_protein__NP_056841__Human_immunodeficiency_virus_2__11709
Identity
- Accession:
- NP_056841 ↗
- Protein ID:
- vpr_protein
- Kingdom:
- euk
Quality
81.6
mean pLDDT
Taxonomy
Pararnavirae›
Artverviricota›
Revtraviricetes›
Ortervirales›
Retroviridae›
Lentivirus›
Human_immunodeficiency_virus_2
TaxID: 11709
Cluster
Singleton — not in a non-trivial cluster
3D Structure
Domains
high = three domain segmentations agree, medium = two domain segmentations agree. Numbered high-first then medium, N→C within each tier.
D1
high
residues 23-79
Domain cluster:
representative
Pfam (1)
| Accession | Name | Score | E-value | Q cov | HMM cov |
|---|---|---|---|---|---|
| PF00522.24 best | VPR | 77.3 | 1.00e-21 | 100.0% | 68.7% |
CATH (40)
| Domain ID | Class ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 7craA02 | 1.20.58.1480 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › | 0.79 | 72.0 | 6.05e-01 | 100.0% | 91.3% |
| 5c8aA01 | 1.10.1240.10 | Mainly Alpha › Orthogonal Bundle › Methyltransferase, Methionine Synthase (B12-binding Domains); Chain A, domain 1 › Methionine synthase domain | 0.74 | 50.0 | 4.49e-01 | 70.2% | 100.0% |
| 2gsvA00 | 6.10.140.40 | Special › Helix non-globular › Helix Hairpins › | 0.70 | 48.0 | 4.59e-01 | 71.9% | 64.2% |
| 1vhnA02 | 1.10.1200.80 | Mainly Alpha › Orthogonal Bundle › Non-ribosomal Peptide Synthetase Peptidyl Carrier Protein; Chain A › Putative flavin oxidoreducatase; domain 2 | 0.70 | 45.0 | 4.24e-01 | 70.2% | 53.5% |
| 3n98A01 | 3.20.110.10 | Alpha Beta › Alpha-Beta Barrel › 7-stranded beta/alpha barrel › Glycoside hydrolase 38, N terminal domain | 0.69 | 55.0 | 3.27e-01 | 86.0% | 81.5% |
| 2zxqA06 | 1.20.1270.70 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › Designed single chain three-helix bundle | 0.68 | 60.0 | 5.79e-01 | 100.0% | 97.0% |
| 2yzcA00 | 3.10.270.10 | Alpha Beta › Roll › Urate Oxidase › Urate Oxidase; | 0.68 | 53.0 | 3.39e-01 | 86.0% | 20.2% |
| 6ynwH01 | 1.20.20.10 | Mainly Alpha › Up-down Bundle › F1FO ATP Synthase › F1F0 ATP synthase subunit C | 0.68 | 50.0 | 4.59e-01 | 78.9% | 63.5% |
| 4kjmA02 | 1.20.5.420 | Mainly Alpha › Up-down Bundle › Single alpha-helices involved in coiled-coils or other helix-helix interfaces › Immunoglobulin FC, subunit C | 0.67 | 51.0 | 5.20e-01 | 91.2% | 89.1% |
| 2qgnA02 | 1.10.287.890 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Crystal structure of tRNA isopentenylpyrophosphate transferase (bh2366) domain | 0.66 | 49.0 | 4.32e-01 | 78.9% | 95.1% |
| 2ex3B02 | 1.20.1270.230 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › DNA terminal protein Gp3, priming domain | 0.65 | 54.0 | 4.87e-01 | 94.7% | 66.7% |
| 4yzgA00 | 3.60.40.10 | Alpha Beta › 4-Layer Sandwich › Phosphatase 2c; domain 1 › PPM-type phosphatase domain | 0.64 | 52.0 | 3.37e-01 | 94.7% | 94.6% |
| 3lcvB01 | 1.10.8.10 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain | 0.64 | 49.0 | 4.96e-01 | 89.5% | 87.7% |
| 3s64A00 | 1.10.225.10 | Mainly Alpha › Orthogonal Bundle › NK-Lysin › Saposin-like | 0.63 | 46.0 | 4.15e-01 | 78.9% | 64.2% |
| 2om6A02 | 1.10.150.400 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › | 0.63 | 46.0 | 4.15e-01 | 77.2% | 70.9% |
| 2lefA00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.63 | 45.0 | 3.89e-01 | 75.4% | 73.3% |
| 1zv1A00 | 1.10.8.10 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Ubiquitin-associated (UBA) domain | 0.62 | 45.0 | 4.52e-01 | 91.2% | 74.6% |
| 1cf7B00 | 1.10.10.10 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain | 0.62 | 44.0 | 3.93e-01 | 73.7% | 51.2% |
| 3t38A01 | 1.10.8.1060 | Mainly Alpha › Orthogonal Bundle › Helicase, Ruva Protein; domain 3 › Corynebacterium glutamicum thioredoxin-dependent arsenate reductase, N-terminal domain | 0.61 | 51.0 | 4.82e-01 | 96.5% | 85.9% |
| 2pmrA00 | 1.20.1270.90 | Mainly Alpha › Up-down Bundle › Substrate Binding Domain Of Dnak; Chain:A; Domain 2 › AF1782-like | 0.61 | 51.0 | 4.76e-01 | 100.0% | 90.8% |
| 2pkeA02 | 1.10.150.240 | Mainly Alpha › Orthogonal Bundle › DNA polymerase; domain 1 › Putative phosphatase; domain 2 | 0.61 | 53.0 | 4.79e-01 | 98.2% | 74.4% |
| 2g80A02 | 1.10.720.60 | Mainly Alpha › Orthogonal Bundle › Transcription Termination Factor Rho, Rna-binding Domain; Chain A, Domain 1 › | 0.60 | 49.0 | 4.46e-01 | 91.2% | 88.5% |
| 2y4tA02 | 1.10.287.110 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › DnaJ domain | 0.59 | 41.0 | 4.25e-01 | 71.9% | 84.6% |
| 2odmA00 | 1.10.287.750 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › SO2669-like | 0.59 | 40.0 | 3.63e-01 | 70.2% | 53.2% |
| 1gt0D00 | 1.10.30.10 | Mainly Alpha › Orthogonal Bundle › DNA Binding (I), subunit A › High mobility group box domain | 0.59 | 42.0 | 3.77e-01 | 75.4% | 79.7% |
| 2qgaB01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.59 | 48.0 | 3.90e-01 | 93.0% | 63.2% |
| 1sxjD03 | 1.20.272.10 | Mainly Alpha › Up-down Bundle › Zinc Finger, Delta Prime; domain 3 › | 0.59 | 44.0 | 3.86e-01 | 84.2% | 95.6% |
| 1np7A02 | 1.25.40.80 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › | 0.58 | 47.0 | 3.74e-01 | 91.2% | 84.9% |
| 1w36F02 | 1.10.10.160 | Mainly Alpha › Orthogonal Bundle › Arc Repressor Mutant, subunit A › | 0.57 | 44.0 | 3.75e-01 | 94.7% | 49.0% |
| 4lvpA00 | 1.10.418.70 | Mainly Alpha › Orthogonal Bundle › Actin-binding Protein, T-fimbrin; domain 1 › Intraflagellar transport protein 81, N-terminal domain | 0.57 | 45.0 | 3.66e-01 | 100.0% | 42.7% |
| 1x4tA01 | 1.10.287.660 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › Helix hairpin bin | 0.57 | 40.0 | 4.02e-01 | 73.7% | 91.4% |
| 3axjB02 | 1.20.58.200 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Translin; domain 2 | 0.56 | 51.0 | 4.44e-01 | 100.0% | 84.7% |
| 1t72A02 | 1.20.58.220 | Mainly Alpha › Up-down Bundle › Methane Monooxygenase Hydroxylase; Chain G, domain 1 › Phosphate transport system protein phou homolog 2; domain 2 | 0.56 | 49.0 | 4.12e-01 | 98.2% | 87.8% |
| 2fu2A00 | 1.20.1440.50 | Mainly Alpha › Up-down Bundle › de novo design (two linked rop proteins) › Ta0600-like | 0.56 | 46.0 | 4.30e-01 | 100.0% | 74.4% |
| 3g0oA02 | 1.10.1040.10 | Mainly Alpha › Orthogonal Bundle › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 › N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase; domain 2 | 0.56 | 38.0 | 2.98e-01 | 70.2% | 90.1% |
| 1tj7A01 | 1.10.275.10 | Mainly Alpha › Orthogonal Bundle › Fumarase C; Chain B, domain 1 › Fumarase/aspartase (N-terminal domain) | 0.54 | 45.0 | 3.77e-01 | 96.5% | 74.3% |
| 2v0xA01 | 1.10.287.3160 | Mainly Alpha › Orthogonal Bundle › Helix Hairpins › | 0.54 | 48.0 | 3.43e-01 | 100.0% | 39.3% |
| 2fe1A00 | 3.40.50.1010 | Alpha Beta › 3-Layer(aba) Sandwich › Rossmann fold › 5'-nuclease | 0.52 | 41.0 | 3.20e-01 | 87.7% | 83.1% |
| 2ynqB00 | 1.25.40.680 | Mainly Alpha › Alpha Horseshoe › Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat › Type VII secretion system EssB, C-terminal-like domain | 0.52 | 42.0 | 3.29e-01 | 100.0% | 52.3% |
| 4gf0A02 | 1.20.1050.10 | Mainly Alpha › Up-down Bundle › Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2 › | 0.51 | 41.0 | 3.36e-01 | 93.0% | 72.6% |
ECOD (44)
| UID | F-ID | Classification | TM-score | Bits | E-value | Q cov | T cov |
|---|---|---|---|---|---|---|---|
| 2819342 | 3788.1.1.1 ↗ | alpha bundles › Viral accessory protein x (Vpx) / viral protein r (Vpr) › Viral accessory protein x (Vpx) / viral protein r (Vpr) › Viral accessory protein x (Vpx) / viral protein r (Vpr) › VPR | 0.92 | 85.0 | 8.20e-01 | 100.0% | 89.1% |
| 1124142 | 3788.1.1.1 ↗ | alpha bundles › Viral accessory protein x (Vpx) / viral protein r (Vpr) › Viral accessory protein x (Vpx) / viral protein r (Vpr) › Viral accessory protein x (Vpx) / viral protein r (Vpr) › VPR | 0.84 | 75.0 | 6.27e-01 | 100.0% | 59.4% |
| 3601478 | 3978.1.1.0 ↗ | alpha complex topology › Integral membrane Acyl-CoA desaturase › Integral membrane Acyl-CoA desaturase › Integral membrane Acyl-CoA desaturase | 0.78 | 54.0 | 3.35e-01 | 73.7% | 14.0% |
| 3987991 | 5086.1.1.94 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HB_LcnD | 0.77 | 57.0 | 3.80e-01 | 78.9% | 28.1% |
| 3825757 | 101.35.1.23 ↗ | alpha arrays › HTH › DNA repair regulatory protein RecX › DNA repair regulatory protein RecX › Ovate | 0.76 | 52.0 | 5.01e-01 | 71.9% | 67.7% |
| 3798232 | 605.1.1.0 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase | 0.74 | 52.0 | 4.48e-01 | 73.7% | 50.0% |
| 3925233 | 101.1.1.0 ↗ | alpha arrays › HTH › HTH › Three-helical HTH | 0.73 | 51.0 | 4.92e-01 | 73.7% | 67.7% |
| 3600611 | 1128.1.1.0 ↗ | alpha bundles › LYR protein › LYR protein › LYR protein | 0.73 | 63.0 | 5.24e-01 | 96.5% | 65.0% |
| 4930612 | 4009.1.1.4 ↗ | alpha bundles › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › alpha-helical domain in AF1104-like proteins › DUF3243 | 0.73 | 50.0 | 4.50e-01 | 75.4% | 51.2% |
| 3617495 | 3860.1.1.0 ↗ | alpha bundles › Myosin VI lever arm › Myosin VI lever arm › Myosin VI lever arm | 0.72 | 50.0 | 4.54e-01 | 73.7% | 55.7% |
| 4237615 | 7515.1.1.15 ↗ | a/b three-layered sandwiches › Alkaline phosphatase-like › Alkaline phosphatase-like › Alkaline phosphatase-like › Phosphodiest, Metalloenzyme | 0.72 | 63.0 | 3.80e-01 | 100.0% | 15.5% |
| 3451236 | 397.4.1.3 ↗ | few secondary structure elements › Toxic hairpin › VhTI-like › VhTI-like › PF31266 | 0.71 | 49.0 | 5.26e-01 | 73.7% | 91.1% |
| 3239257 | 103.1.1.0 ↗ | alpha arrays › RuvA-C › RuvA-C, UBA, CRAL/TRIO-N, HBS1 › UBA-like domain | 0.71 | 50.0 | 4.92e-01 | 82.5% | 70.0% |
| 5060145 | 632.22.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Cell division protein EzrA repeats › Cell division protein EzrA repeats | 0.70 | 62.0 | 5.96e-01 | 100.0% | 93.8% |
| 3281755 | 142.1.1.0 ↗ | alpha complex topology › Sigma2 domain-like › Sigma2 domain of RNA polymerase sigma factors › Sigma2 domain of RNA polymerase sigma factors | 0.70 | 49.0 | 4.86e-01 | 73.7% | 83.3% |
| 4082099 | 7516.1.1.2 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glycos_transf_2 | 0.70 | 49.0 | 3.03e-01 | 73.7% | 13.3% |
| 3896752 | 632.3.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › Phosphoprotein XD domain › Phosphoprotein XD domain | 0.70 | 60.0 | 5.96e-01 | 100.0% | 91.7% |
| 3711095 | 3075.1.1.0 ↗ | a+b two layers › ubiquitin-binding domain from PLAA › ubiquitin-binding domain from PLAA › ubiquitin-binding domain from PLAA | 0.68 | 49.0 | 4.47e-01 | 77.2% | 81.3% |
| 3794794 | 7516.1.1.51 ↗ | a/b three-layered sandwiches › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Nucleotide-diphospho-sugar transferases › Glyco_transf_21 | 0.66 | 45.0 | 2.98e-01 | 73.7% | 54.7% |
| 3678035 | 605.1.1.1 ↗ | alpha duplicates or obligate multimers › ROP-like › Homodimeric domain of signal transducing histidine kinase › Homodimeric domain of signal transducing histidine kinase › HisKA | 0.66 | 43.0 | 3.99e-01 | 71.9% | 54.3% |
| 3597506 | 5041.1.1.0 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C | 0.66 | 46.0 | 4.22e-01 | 73.7% | 62.7% |
| 3518991 | 284.1.3.4 ↗ | a+b two layers › FKBP-like › FKBP-like › WNK1 autoinhibitory domain › CCTL2_WNK | 0.65 | 46.0 | 4.18e-01 | 73.7% | 56.0% |
| 4276514 | 3826.1.1.88 ↗ | alpha bundles › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › Copper-sensitive operon repressor (CsoR) › CC_BshC | 0.65 | 47.0 | 4.36e-01 | 75.4% | 94.3% |
| 5002758 | 4030.1.1.0 ↗ | alpha bundles › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz › alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz | 0.64 | 45.0 | 4.46e-01 | 73.7% | 70.0% |
| 3036753 | 397.7.1.0 ↗ | few secondary structure elements › Toxic hairpin › Ribosome-inactivating protein luffin P1 › Ribosome-inactivating protein luffin P1 | 0.63 | 44.0 | 4.49e-01 | 82.5% | 76.8% |
| 3807250 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.63 | 46.0 | 4.54e-01 | 78.9% | 76.7% |
| 5074957 | 632.11.1.0 ↗ | alpha bundles › immunoglobulin/albumin-binding domain-like › AF1782-like › AF1782-like | 0.63 | 53.0 | 5.02e-01 | 96.5% | 90.0% |
| 3982740 | 5086.1.1.190 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › OEP | 0.63 | 44.0 | 2.98e-01 | 73.7% | 46.0% |
| 3594394 | 3651.1.1.0 ↗ | alpha bundles › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain › Translation initiation factor eIF-2B delta subunit N-terminal helical domain | 0.63 | 56.0 | 4.88e-01 | 100.0% | 81.2% |
| 4086475 | 3755.3.1.466 ↗ | alpha bundles › YscO-like › CT398 helical hairpin › CT398 helical hairpin › CC_BshC | 0.63 | 43.0 | 3.25e-01 | 73.7% | 27.1% |
| 4006721 | 325.1.7.50 ↗ | a+b complex topology › alpha/beta-Hammerhead/Barrel-sandwich hybrid › alpha/beta-Hammerhead/Barrel-sandwich hybrid › Single hybrid motif › PF25876 | 0.63 | 44.0 | 3.82e-01 | 73.7% | 70.6% |
| 4525341 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.63 | 44.0 | 4.12e-01 | 73.7% | 65.7% |
| 4026417 | 5041.1.1.1 ↗ | extended segments › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › F1F0 ATP synthase subunit C › ATP-synt_C | 0.62 | 43.0 | 4.01e-01 | 73.7% | 58.7% |
| 4987508 | 1128.1.1.0 ↗ | alpha bundles › LYR protein › LYR protein › LYR protein | 0.62 | 55.0 | 5.04e-01 | 100.0% | 81.3% |
| 4125915 | 186.1.1.1 ↗ | alpha arrays › lambda integrase-N-like › lambda integrase-N › lambda integrase-N › Phage_int_SAM_1 | 0.61 | 42.0 | 3.48e-01 | 71.9% | 41.0% |
| 3806413 | 4133.1.1.0 ↗ | alpha arrays › Emsy N terminal (ENT) domain-like › Emsy N terminal (ENT) domain-like › Emsy N terminal (ENT) domain-like | 0.61 | 48.0 | 3.56e-01 | 87.7% | 65.8% |
| 3386973 | 5086.1.1.84 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND | 0.61 | 42.0 | 3.59e-01 | 71.9% | 96.7% |
| 3386333 | 138.1.1.0 ↗ | alpha arrays › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain › DNA polymerase III clamp loader subunits, C-terminal domain | 0.60 | 46.0 | 4.33e-01 | 89.5% | 68.0% |
| 3791357 | 5086.1.1.0 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins | 0.60 | 42.0 | 2.99e-01 | 73.7% | 25.5% |
| 3482901 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.58 | 40.0 | 3.73e-01 | 77.2% | 60.0% |
| 3491082 | 198.1.1.0 ↗ | alpha arrays › Saposin-like › Saposin-like › Saposin-like | 0.55 | 38.0 | 3.65e-01 | 77.2% | 59.5% |
| 3971758 | 5086.1.1.84 ↗ | alpha bundles › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › helical hairpin of HlyD-like secretion proteins › HH_MFP_RND | 0.53 | 40.0 | 3.43e-01 | 78.9% | 62.4% |
| 3655800 | 101.1.17.31 ↗ | alpha arrays › HTH › HTH › FF domain › NifU_N | 0.52 | 34.0 | 3.39e-01 | 71.9% | 61.5% |
| 3299919 | 568.1.1.6 ↗ | few secondary structure elements › p8-MTCP1-related › p8-MTCP1-related › p8-MTCP1-related › CX9C | 0.51 | 35.0 | 3.18e-01 | 71.9% | 52.5% |